Evaluation of biological activity, toxicity, and phytochemical content of Bowdichia virgilioides (Fabaceae) aqueous extract
Background: Antibiotic resistance is a worldwide problem that poses a serious threat to human health, limiting the therapeutic options for bacterial infections. The spread of falciparum-resistant malaria is also concerning, making the patient treatment an extremely difficult task. Those facts have h...
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| Veröffentlicht in: | Pharmacognosy Magazine 2018-07, Vol.14 (57), p.403-408 |
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| creator | Assis, Isabela Mauricio da Rocha, Eliana Martins Guimarães, Daniel do Nascimento Pereira, Glaécia Pereira, Fabiana Siqueira Ferreira, Jaqueline Barreto, Emiliano |
| description | Background: Antibiotic resistance is a worldwide problem that poses a serious threat to human health, limiting the therapeutic options for bacterial infections. The spread of falciparum-resistant malaria is also concerning, making the patient treatment an extremely difficult task. Those facts have heightened the interest to find alternate options to treat infections caused by drug-resistant microorganisms. Objective: Considering the importance of the development of new substances with antibacterial and antimalarial properties, the present study aimed to investigate the activity of the aqueous extract of stem bark of Bowdichia virgilioides (AEBv). This plant is commonly used in Brazilian folk medicine to treat a wide range of illnesses, including signs and symptoms associated with malaria. Materials and Methods: The AEBv was assayed for toxicity against two cell lines and Artemia salina larvae. In vitro activity of the extract was screened against a panel of Gram-positive and Gram-negative bacteria, a chloroquine-resistant (W2) and a chloroquine-sensitive (3D7) Plasmodium falciparum strains. The extract was also tested as antimalarial in vivo against Plasmodium berghei. Results: The AEBv presented no significant toxicity and was found to exert in vitro growth inhibitory effect against the tested bacterial species. The lowest minimal inhibitory concentration was reported for Staphylococcus aureus (0.125 mg/ml) followed by Staphylococcus epidermidis and Staphylococcus saprophyticus (0.50 mg/ml). B. virgilioides extract showed weak in vitro antimalarial activity against P. falciparum. A preliminary phytochemical analysis revealed the presence of flavonoids, phenolic groups, terpenoids, saponins, and tannins and the absence of alkaloids. Conclusion: The AEBv showed promising activity against Gram-positive microorganisms.
Abbreviation used: AEBv: Aqueous extract of stem bark of Bowdichia virgilioides; FBS: fetal bovine serum; CC50: 50% cytotoxic concentration; LC50: Median lethal concentration; ATCC: American Type Culture Collection; MIC: Minimum inhibitory concentration; MBC: Minimum bactericidal concentrations; CQR: Chloroquine resistant; CQS: Chloroquine-sensitive; HRP2 Histidine rich protein 2; ELISA: Enzyme linked immunosorbent assay; PBS T: Phosphate buffer saline with 0.05% Tween 20; ANOVA: Analysis of variance; TLC: Thin layer chromatography; Rf: Retention factor; SI: Selectivity índex; MRSA: Methicillin resistant Staphylococcus aureus. |
| doi_str_mv | 10.4103/pm.pm_273_17 |
| format | Article |
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Abbreviation used: AEBv: Aqueous extract of stem bark of Bowdichia virgilioides; FBS: fetal bovine serum; CC50: 50% cytotoxic concentration; LC50: Median lethal concentration; ATCC: American Type Culture Collection; MIC: Minimum inhibitory concentration; MBC: Minimum bactericidal concentrations; CQR: Chloroquine resistant; CQS: Chloroquine-sensitive; HRP2 Histidine rich protein 2; ELISA: Enzyme linked immunosorbent assay; PBS T: Phosphate buffer saline with 0.05% Tween 20; ANOVA: Analysis of variance; TLC: Thin layer chromatography; Rf: Retention factor; SI: Selectivity índex; MRSA: Methicillin resistant Staphylococcus aureus.</description><identifier>ISSN: 0973-1296</identifier><identifier>EISSN: 0976-4062</identifier><identifier>DOI: 10.4103/pm.pm_273_17</identifier><language>eng</language><publisher>London: Wolters Kluwer India Pvt. Ltd</publisher><subject>Anti-infective agents ; Antimicrobial agents ; Bioassays ; Biological activity ; Care and treatment ; Chemical properties ; Cytotoxicity ; Drug resistance ; Flavonoids ; Flowers & plants ; Gram-positive bacterial infections ; Health aspects ; Herbal medicine ; Infectious diseases ; Legumes ; Malaria ; Medical equipment ; Medicine ; Metabolites ; Microorganisms ; Natural products ; Nosocomial infections ; Pharmacognosy ; Pharmacological research ; Physiological aspects ; Phytochemicals ; Plant extracts ; Public health</subject><ispartof>Pharmacognosy Magazine, 2018-07, Vol.14 (57), p.403-408</ispartof><rights>COPYRIGHT 2018 Medknow Publications and Media Pvt. Ltd.</rights><rights>2018. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c342i-6102b3c9a5ef12810f2e6012c357a3f8ce28889a662852f5288612f99bc9c5353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids></links><search><creatorcontrib>Assis, Isabela</creatorcontrib><creatorcontrib>Mauricio da Rocha, Eliana</creatorcontrib><creatorcontrib>Martins Guimarães, Daniel</creatorcontrib><creatorcontrib>do Nascimento Pereira, Glaécia</creatorcontrib><creatorcontrib>Pereira, Fabiana</creatorcontrib><creatorcontrib>Siqueira Ferreira, Jaqueline</creatorcontrib><creatorcontrib>Barreto, Emiliano</creatorcontrib><title>Evaluation of biological activity, toxicity, and phytochemical content of Bowdichia virgilioides (Fabaceae) aqueous extract</title><title>Pharmacognosy Magazine</title><description>Background: Antibiotic resistance is a worldwide problem that poses a serious threat to human health, limiting the therapeutic options for bacterial infections. The spread of falciparum-resistant malaria is also concerning, making the patient treatment an extremely difficult task. Those facts have heightened the interest to find alternate options to treat infections caused by drug-resistant microorganisms. Objective: Considering the importance of the development of new substances with antibacterial and antimalarial properties, the present study aimed to investigate the activity of the aqueous extract of stem bark of Bowdichia virgilioides (AEBv). This plant is commonly used in Brazilian folk medicine to treat a wide range of illnesses, including signs and symptoms associated with malaria. Materials and Methods: The AEBv was assayed for toxicity against two cell lines and Artemia salina larvae. In vitro activity of the extract was screened against a panel of Gram-positive and Gram-negative bacteria, a chloroquine-resistant (W2) and a chloroquine-sensitive (3D7) Plasmodium falciparum strains. The extract was also tested as antimalarial in vivo against Plasmodium berghei. Results: The AEBv presented no significant toxicity and was found to exert in vitro growth inhibitory effect against the tested bacterial species. The lowest minimal inhibitory concentration was reported for Staphylococcus aureus (0.125 mg/ml) followed by Staphylococcus epidermidis and Staphylococcus saprophyticus (0.50 mg/ml). B. virgilioides extract showed weak in vitro antimalarial activity against P. falciparum. A preliminary phytochemical analysis revealed the presence of flavonoids, phenolic groups, terpenoids, saponins, and tannins and the absence of alkaloids. Conclusion: The AEBv showed promising activity against Gram-positive microorganisms.
Abbreviation used: AEBv: Aqueous extract of stem bark of Bowdichia virgilioides; FBS: fetal bovine serum; CC50: 50% cytotoxic concentration; LC50: Median lethal concentration; ATCC: American Type Culture Collection; MIC: Minimum inhibitory concentration; MBC: Minimum bactericidal concentrations; CQR: Chloroquine resistant; CQS: Chloroquine-sensitive; HRP2 Histidine rich protein 2; ELISA: Enzyme linked immunosorbent assay; PBS T: Phosphate buffer saline with 0.05% Tween 20; ANOVA: Analysis of variance; TLC: Thin layer chromatography; Rf: Retention factor; SI: Selectivity índex; MRSA: Methicillin resistant Staphylococcus aureus.</description><subject>Anti-infective agents</subject><subject>Antimicrobial agents</subject><subject>Bioassays</subject><subject>Biological activity</subject><subject>Care and treatment</subject><subject>Chemical properties</subject><subject>Cytotoxicity</subject><subject>Drug resistance</subject><subject>Flavonoids</subject><subject>Flowers & plants</subject><subject>Gram-positive bacterial infections</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Infectious diseases</subject><subject>Legumes</subject><subject>Malaria</subject><subject>Medical equipment</subject><subject>Medicine</subject><subject>Metabolites</subject><subject>Microorganisms</subject><subject>Natural products</subject><subject>Nosocomial infections</subject><subject>Pharmacognosy</subject><subject>Pharmacological research</subject><subject>Physiological aspects</subject><subject>Phytochemicals</subject><subject>Plant extracts</subject><subject>Public health</subject><issn>0973-1296</issn><issn>0976-4062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU1r3DAQhk1poWnSW3-AoJcW4o0-LNm-FNKQtIVAL8lZaOXR7iS25Urybpb--Wp3-0Eh6KDR8Lyjl3mL4h2ji4pRcTENi2nQvBaa1S-KE9rWqqyo4i8PtSgZb9Xr4k2MD5TKhtH6pPh5vTH9bBL6kXhHluh7v0JremJswg2m3TlJ_gntoTJjR6b1Lnm7huFAWT8mGNNe-9lvO7RrNGSDYYU9euwgkg83ZmksGPhIzI8Z_BwJPKWQx58Vr5zpI7z9fZ8W9zfXd1dfy9vvX75dXd6WVlQcS8UoXwrbGgmO8WzbcVCUcStkbYRrLPCmaVqjFG8kdzK_FOOubZe2tVJIcVq8P86dgs8OYtIPfg5j_lLzvLZKCEn5P2pletA4Or83OWC0-lLKignVVipTi2eofLr9QvwIDnP_P8H5UWCDjzGA01PAwYSdZlTvU9M5sr-pZfzTEd_6PkGIj_28haAH6B5Hv31Wo6vc-BOj-AUIf6CW</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Assis, Isabela</creator><creator>Mauricio da Rocha, Eliana</creator><creator>Martins Guimarães, Daniel</creator><creator>do Nascimento Pereira, Glaécia</creator><creator>Pereira, Fabiana</creator><creator>Siqueira Ferreira, Jaqueline</creator><creator>Barreto, Emiliano</creator><general>Wolters Kluwer India Pvt. 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Magazine</jtitle><date>2018-07-01</date><risdate>2018</risdate><volume>14</volume><issue>57</issue><spage>403</spage><epage>408</epage><pages>403-408</pages><issn>0973-1296</issn><eissn>0976-4062</eissn><abstract>Background: Antibiotic resistance is a worldwide problem that poses a serious threat to human health, limiting the therapeutic options for bacterial infections. The spread of falciparum-resistant malaria is also concerning, making the patient treatment an extremely difficult task. Those facts have heightened the interest to find alternate options to treat infections caused by drug-resistant microorganisms. Objective: Considering the importance of the development of new substances with antibacterial and antimalarial properties, the present study aimed to investigate the activity of the aqueous extract of stem bark of Bowdichia virgilioides (AEBv). This plant is commonly used in Brazilian folk medicine to treat a wide range of illnesses, including signs and symptoms associated with malaria. Materials and Methods: The AEBv was assayed for toxicity against two cell lines and Artemia salina larvae. In vitro activity of the extract was screened against a panel of Gram-positive and Gram-negative bacteria, a chloroquine-resistant (W2) and a chloroquine-sensitive (3D7) Plasmodium falciparum strains. The extract was also tested as antimalarial in vivo against Plasmodium berghei. Results: The AEBv presented no significant toxicity and was found to exert in vitro growth inhibitory effect against the tested bacterial species. The lowest minimal inhibitory concentration was reported for Staphylococcus aureus (0.125 mg/ml) followed by Staphylococcus epidermidis and Staphylococcus saprophyticus (0.50 mg/ml). B. virgilioides extract showed weak in vitro antimalarial activity against P. falciparum. A preliminary phytochemical analysis revealed the presence of flavonoids, phenolic groups, terpenoids, saponins, and tannins and the absence of alkaloids. Conclusion: The AEBv showed promising activity against Gram-positive microorganisms.
Abbreviation used: AEBv: Aqueous extract of stem bark of Bowdichia virgilioides; FBS: fetal bovine serum; CC50: 50% cytotoxic concentration; LC50: Median lethal concentration; ATCC: American Type Culture Collection; MIC: Minimum inhibitory concentration; MBC: Minimum bactericidal concentrations; CQR: Chloroquine resistant; CQS: Chloroquine-sensitive; HRP2 Histidine rich protein 2; ELISA: Enzyme linked immunosorbent assay; PBS T: Phosphate buffer saline with 0.05% Tween 20; ANOVA: Analysis of variance; TLC: Thin layer chromatography; Rf: Retention factor; SI: Selectivity índex; MRSA: Methicillin resistant Staphylococcus aureus.</abstract><cop>London</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><doi>10.4103/pm.pm_273_17</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-infective agents Antimicrobial agents Bioassays Biological activity Care and treatment Chemical properties Cytotoxicity Drug resistance Flavonoids Flowers & plants Gram-positive bacterial infections Health aspects Herbal medicine Infectious diseases Legumes Malaria Medical equipment Medicine Metabolites Microorganisms Natural products Nosocomial infections Pharmacognosy Pharmacological research Physiological aspects Phytochemicals Plant extracts Public health |
| title | Evaluation of biological activity, toxicity, and phytochemical content of Bowdichia virgilioides (Fabaceae) aqueous extract |
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