Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain
Kinesins are one of the neoteric and efficacious targets recently reported to play an important role in the initiation and progression of chronic pain. Kinesins are anterograde microtubule-based motor proteins that are involved in trafficking of receptors including nociceptors and progression of pai...
Gespeichert in:
| Veröffentlicht in: | Molecular neurobiology 2019-06, Vol.56 (6), p.3854-3864 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3864 |
|---|---|
| container_issue | 6 |
| container_start_page | 3854 |
| container_title | Molecular neurobiology |
| container_volume | 56 |
| creator | Shantanu, P. A. Sharma, Dilip Sharma, Monika Vaidya, Shivani Sharma, Kuhu Kalia, Kiran Tao, Yuan-Xiang Shard, Amit Tiwari, Vinod |
| description | Kinesins are one of the neoteric and efficacious targets recently reported to play an important role in the initiation and progression of chronic pain. Kinesins are anterograde microtubule-based motor proteins that are involved in trafficking of receptors including nociceptors and progression of pain. The specific kinesin and regulatory proteins interplay is crucial for the delivery of nociceptors to the synapse. If this complex and less understood interplay is inhibited, it may result in a decrease in central sensitization, and thus attenuation of pain. This review is focused on the transportation process of receptors/cargos, the role of regulatory proteins influencing the respective kinesin, and their relationship with chronic pain. The review also features specific strategies adopted by researchers for targeting kinesin and chronic pain. Considering the recent preclinical success of kinesin inhibition in pain, it is expected that inhibitors for kinesin or enzymes responsible for kinesin activation could be developed or repurposed as alternative, safe, and potential therapies for the treatment of chronic pain. |
| doi_str_mv | 10.1007/s12035-018-1327-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2103363656</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2103363656</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-18345fd06e5d5746cda94c69da0644cab5a02b7d10cafeb87ee73bc92578d3f83</originalsourceid><addsrcrecordid>eNp1kMtOAjEUhhujEUQfwI1p4rray_Qy7gzxjsoC102n04EhMMW2mPD2loC6cnVycv5LzgfAOcFXBGN5HQnFjCNMFCKMSrQ5AH3CeYkIUfQQ9LEqGZKiUD1wEuMcY0oJlsegxzAlnPCyD55f2s7Ftos38NUnH-A4-OTyDk2Eb_7LLeDEhKlLsMnHNHNwEpxJS9cl6Bs4nAXftRaOTdudgqPGLKI7288B-Li_mwwf0ej94Wl4O0KWSZoQUazgTY2F4zWXhbC1KQsrytpgURTWVNxgWsmaYGsaVynpnGSVLSmXqmaNYgNwuctdBf-5djHpuV-HLlfq_B5jggkusorsVDb4GINr9Cq0SxM2mmC9pad39HSmp7f09CZ7LvbJ62rp6l_HD64soDtBzKdu6sJf9f-p31Djefk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2103363656</pqid></control><display><type>article</type><title>Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Shantanu, P. A. ; Sharma, Dilip ; Sharma, Monika ; Vaidya, Shivani ; Sharma, Kuhu ; Kalia, Kiran ; Tao, Yuan-Xiang ; Shard, Amit ; Tiwari, Vinod</creator><creatorcontrib>Shantanu, P. A. ; Sharma, Dilip ; Sharma, Monika ; Vaidya, Shivani ; Sharma, Kuhu ; Kalia, Kiran ; Tao, Yuan-Xiang ; Shard, Amit ; Tiwari, Vinod</creatorcontrib><description>Kinesins are one of the neoteric and efficacious targets recently reported to play an important role in the initiation and progression of chronic pain. Kinesins are anterograde microtubule-based motor proteins that are involved in trafficking of receptors including nociceptors and progression of pain. The specific kinesin and regulatory proteins interplay is crucial for the delivery of nociceptors to the synapse. If this complex and less understood interplay is inhibited, it may result in a decrease in central sensitization, and thus attenuation of pain. This review is focused on the transportation process of receptors/cargos, the role of regulatory proteins influencing the respective kinesin, and their relationship with chronic pain. The review also features specific strategies adopted by researchers for targeting kinesin and chronic pain. Considering the recent preclinical success of kinesin inhibition in pain, it is expected that inhibitors for kinesin or enzymes responsible for kinesin activation could be developed or repurposed as alternative, safe, and potential therapies for the treatment of chronic pain.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-018-1327-y</identifier><identifier>PMID: 30215159</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Bone cancer ; Cell Biology ; Chronic pain ; Chronic Pain - drug therapy ; Humans ; Kinesin ; Kinesin - metabolism ; Molecular Targeted Therapy ; Neurobiology ; Neurology ; Neurosciences ; Nociceptors ; Pain ; Pain perception ; Protein transport ; Proteins ; Receptors, Cell Surface - metabolism ; Regulatory proteins ; Sodium Channels - metabolism ; Synapses</subject><ispartof>Molecular neurobiology, 2019-06, Vol.56 (6), p.3854-3864</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Molecular Neurobiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-18345fd06e5d5746cda94c69da0644cab5a02b7d10cafeb87ee73bc92578d3f83</citedby><cites>FETCH-LOGICAL-c372t-18345fd06e5d5746cda94c69da0644cab5a02b7d10cafeb87ee73bc92578d3f83</cites><orcidid>0000-0002-8491-2255</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-018-1327-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-018-1327-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30215159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shantanu, P. A.</creatorcontrib><creatorcontrib>Sharma, Dilip</creatorcontrib><creatorcontrib>Sharma, Monika</creatorcontrib><creatorcontrib>Vaidya, Shivani</creatorcontrib><creatorcontrib>Sharma, Kuhu</creatorcontrib><creatorcontrib>Kalia, Kiran</creatorcontrib><creatorcontrib>Tao, Yuan-Xiang</creatorcontrib><creatorcontrib>Shard, Amit</creatorcontrib><creatorcontrib>Tiwari, Vinod</creatorcontrib><title>Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Kinesins are one of the neoteric and efficacious targets recently reported to play an important role in the initiation and progression of chronic pain. Kinesins are anterograde microtubule-based motor proteins that are involved in trafficking of receptors including nociceptors and progression of pain. The specific kinesin and regulatory proteins interplay is crucial for the delivery of nociceptors to the synapse. If this complex and less understood interplay is inhibited, it may result in a decrease in central sensitization, and thus attenuation of pain. This review is focused on the transportation process of receptors/cargos, the role of regulatory proteins influencing the respective kinesin, and their relationship with chronic pain. The review also features specific strategies adopted by researchers for targeting kinesin and chronic pain. Considering the recent preclinical success of kinesin inhibition in pain, it is expected that inhibitors for kinesin or enzymes responsible for kinesin activation could be developed or repurposed as alternative, safe, and potential therapies for the treatment of chronic pain.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone cancer</subject><subject>Cell Biology</subject><subject>Chronic pain</subject><subject>Chronic Pain - drug therapy</subject><subject>Humans</subject><subject>Kinesin</subject><subject>Kinesin - metabolism</subject><subject>Molecular Targeted Therapy</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nociceptors</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Protein transport</subject><subject>Proteins</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Regulatory proteins</subject><subject>Sodium Channels - metabolism</subject><subject>Synapses</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtOAjEUhhujEUQfwI1p4rray_Qy7gzxjsoC102n04EhMMW2mPD2loC6cnVycv5LzgfAOcFXBGN5HQnFjCNMFCKMSrQ5AH3CeYkIUfQQ9LEqGZKiUD1wEuMcY0oJlsegxzAlnPCyD55f2s7Ftos38NUnH-A4-OTyDk2Eb_7LLeDEhKlLsMnHNHNwEpxJS9cl6Bs4nAXftRaOTdudgqPGLKI7288B-Li_mwwf0ej94Wl4O0KWSZoQUazgTY2F4zWXhbC1KQsrytpgURTWVNxgWsmaYGsaVynpnGSVLSmXqmaNYgNwuctdBf-5djHpuV-HLlfq_B5jggkusorsVDb4GINr9Cq0SxM2mmC9pad39HSmp7f09CZ7LvbJ62rp6l_HD64soDtBzKdu6sJf9f-p31Djefk</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Shantanu, P. A.</creator><creator>Sharma, Dilip</creator><creator>Sharma, Monika</creator><creator>Vaidya, Shivani</creator><creator>Sharma, Kuhu</creator><creator>Kalia, Kiran</creator><creator>Tao, Yuan-Xiang</creator><creator>Shard, Amit</creator><creator>Tiwari, Vinod</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-8491-2255</orcidid></search><sort><creationdate>20190601</creationdate><title>Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain</title><author>Shantanu, P. A. ; Sharma, Dilip ; Sharma, Monika ; Vaidya, Shivani ; Sharma, Kuhu ; Kalia, Kiran ; Tao, Yuan-Xiang ; Shard, Amit ; Tiwari, Vinod</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-18345fd06e5d5746cda94c69da0644cab5a02b7d10cafeb87ee73bc92578d3f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone cancer</topic><topic>Cell Biology</topic><topic>Chronic pain</topic><topic>Chronic Pain - drug therapy</topic><topic>Humans</topic><topic>Kinesin</topic><topic>Kinesin - metabolism</topic><topic>Molecular Targeted Therapy</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nociceptors</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Protein transport</topic><topic>Proteins</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Regulatory proteins</topic><topic>Sodium Channels - metabolism</topic><topic>Synapses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shantanu, P. A.</creatorcontrib><creatorcontrib>Sharma, Dilip</creatorcontrib><creatorcontrib>Sharma, Monika</creatorcontrib><creatorcontrib>Vaidya, Shivani</creatorcontrib><creatorcontrib>Sharma, Kuhu</creatorcontrib><creatorcontrib>Kalia, Kiran</creatorcontrib><creatorcontrib>Tao, Yuan-Xiang</creatorcontrib><creatorcontrib>Shard, Amit</creatorcontrib><creatorcontrib>Tiwari, Vinod</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shantanu, P. A.</au><au>Sharma, Dilip</au><au>Sharma, Monika</au><au>Vaidya, Shivani</au><au>Sharma, Kuhu</au><au>Kalia, Kiran</au><au>Tao, Yuan-Xiang</au><au>Shard, Amit</au><au>Tiwari, Vinod</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>56</volume><issue>6</issue><spage>3854</spage><epage>3864</epage><pages>3854-3864</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Kinesins are one of the neoteric and efficacious targets recently reported to play an important role in the initiation and progression of chronic pain. Kinesins are anterograde microtubule-based motor proteins that are involved in trafficking of receptors including nociceptors and progression of pain. The specific kinesin and regulatory proteins interplay is crucial for the delivery of nociceptors to the synapse. If this complex and less understood interplay is inhibited, it may result in a decrease in central sensitization, and thus attenuation of pain. This review is focused on the transportation process of receptors/cargos, the role of regulatory proteins influencing the respective kinesin, and their relationship with chronic pain. The review also features specific strategies adopted by researchers for targeting kinesin and chronic pain. Considering the recent preclinical success of kinesin inhibition in pain, it is expected that inhibitors for kinesin or enzymes responsible for kinesin activation could be developed or repurposed as alternative, safe, and potential therapies for the treatment of chronic pain.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30215159</pmid><doi>10.1007/s12035-018-1327-y</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8491-2255</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-7648 |
| ispartof | Molecular neurobiology, 2019-06, Vol.56 (6), p.3854-3864 |
| issn | 0893-7648 1559-1182 |
| language | eng |
| recordid | cdi_proquest_journals_2103363656 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Biomedical and Life Sciences Biomedicine Bone cancer Cell Biology Chronic pain Chronic Pain - drug therapy Humans Kinesin Kinesin - metabolism Molecular Targeted Therapy Neurobiology Neurology Neurosciences Nociceptors Pain Pain perception Protein transport Proteins Receptors, Cell Surface - metabolism Regulatory proteins Sodium Channels - metabolism Synapses |
| title | Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T12%3A59%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Kinesins:%20Motor%20Proteins%20as%20Novel%20Target%20for%20the%20Treatment%20of%20Chronic%20Pain&rft.jtitle=Molecular%20neurobiology&rft.au=Shantanu,%20P.%20A.&rft.date=2019-06-01&rft.volume=56&rft.issue=6&rft.spage=3854&rft.epage=3864&rft.pages=3854-3864&rft.issn=0893-7648&rft.eissn=1559-1182&rft_id=info:doi/10.1007/s12035-018-1327-y&rft_dat=%3Cproquest_cross%3E2103363656%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2103363656&rft_id=info:pmid/30215159&rfr_iscdi=true |