The  -galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist

Neutrophils interacting with a chemoattractant gradually become nonresponsive to further stimulation by the same agonist, a process known as desensitization. Receptor desensitization is a highly regulated process that involves different mechanisms depending on which receptor-ligand pair that is stud...

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Veröffentlicht in:	Glycobiology (Oxford) 2008-11, Vol.18 (11), p.905-912
Hauptverfasser:	Forsman, H., Salomonsson, E., Onnheim, K., Karlsson, J., Bjorstad, A., Leffler, H., Bylund, J., Karlsson, A., Dahlgren, C.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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