Kinetics of heterogeneous-induced degradation for artesunate and artemether
This paper presents the results obtained after the investigation of two artemisinin derived sesquiterpenes, namely artesunate and artemether, currently studied for their antitumor properties. The chosen methods of analysis included UATR–FTIR spectroscopy, characterization of the thermal behavior (TG...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2018-10, Vol.134 (1), p.749-756 |
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| container_title | Journal of thermal analysis and calorimetry |
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| creator | Circioban, Denisa Ledeţi, Ionuţ Vlase, Gabriela Ledeţi, Adriana Axente, Carmen Vlase, Titus Dehelean, Cristina |
| description | This paper presents the results obtained after the investigation of two artemisinin derived sesquiterpenes, namely artesunate and artemether, currently studied for their antitumor properties. The chosen methods of analysis included UATR–FTIR spectroscopy, characterization of the thermal behavior (TG/DTG/HF) in oxidative dynamic atmosphere, and a complete kinetic analysis. The latter was realized using two integral methods (Kissinger–Akahira–Sunose and Flynn–Wall–Ozawa), a differential one (Friedman), and was later completed with the modified NPK method. The study showed that both compounds show similar thermal stability in terms of apparent activation energies and the degradation processes occur in two parallel steps for each compound, this being solely due to chemical transformations. |
| doi_str_mv | 10.1007/s10973-018-7257-0 |
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The chosen methods of analysis included UATR–FTIR spectroscopy, characterization of the thermal behavior (TG/DTG/HF) in oxidative dynamic atmosphere, and a complete kinetic analysis. The latter was realized using two integral methods (Kissinger–Akahira–Sunose and Flynn–Wall–Ozawa), a differential one (Friedman), and was later completed with the modified NPK method. 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The study showed that both compounds show similar thermal stability in terms of apparent activation energies and the degradation processes occur in two parallel steps for each compound, this being solely due to chemical transformations.</description><subject>Analytical Chemistry</subject><subject>Anticancer properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Degradation</subject><subject>Fourier transforms</subject><subject>Inorganic Chemistry</subject><subject>Measurement Science and Instrumentation</subject><subject>Organic chemistry</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Thermal stability</subject><subject>Thermodynamic properties</subject><issn>1388-6150</issn><issn>1588-2926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kV1LBCEUhocoqLZ-QHcDXXUxm2c-HL1coo-lIKi9F1ePk9Hqpg7Uv8_aYFkovfCoz3NE3qI4AzIFQvrLCIT3TUWAVX3d9RXZK46gY6yqeU33c93kmkJHDovjGF8JIZwTOCru763DZFUsvSlfMGHwAzr0Y6ys06NCXWocgtQyWe9K40MpQ8I4OpmwlE7_bFeYXjCcFAdGvkU8_V0nxeLmenF1Vz083s6vZg-Vars2VbrVLepGLoHUiqp6yRnwhnEN3LSa5tEA1H2_NLSljElKGeFKdQZkq-iymRTnm7br4N9HjEm8-jG4_KKoc8uGAem6LTXINxTWGZ-CVCsblZjla94y6Fmmpn9QeWpcWeUdGpvPd4SLHSEzCT_SIMcYxfz5aZeFDauCjzGgEetgVzJ8CiDiOzWxSU3k1MR3aoJkp944MbNuwLD93P_SF5Lsl58</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Circioban, Denisa</creator><creator>Ledeţi, Ionuţ</creator><creator>Vlase, Gabriela</creator><creator>Ledeţi, Adriana</creator><creator>Axente, Carmen</creator><creator>Vlase, Titus</creator><creator>Dehelean, Cristina</creator><general>Springer International Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>20181001</creationdate><title>Kinetics of heterogeneous-induced degradation for artesunate and artemether</title><author>Circioban, Denisa ; Ledeţi, Ionuţ ; Vlase, Gabriela ; Ledeţi, Adriana ; Axente, Carmen ; Vlase, Titus ; Dehelean, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-d4d4ed3ab102c6c2b9819389d19f4d6666311277bf64688a66809cc5f1a4c6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analytical Chemistry</topic><topic>Anticancer properties</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Degradation</topic><topic>Fourier transforms</topic><topic>Inorganic Chemistry</topic><topic>Measurement Science and Instrumentation</topic><topic>Organic chemistry</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Thermal stability</topic><topic>Thermodynamic properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Circioban, Denisa</creatorcontrib><creatorcontrib>Ledeţi, Ionuţ</creatorcontrib><creatorcontrib>Vlase, Gabriela</creatorcontrib><creatorcontrib>Ledeţi, Adriana</creatorcontrib><creatorcontrib>Axente, Carmen</creatorcontrib><creatorcontrib>Vlase, Titus</creatorcontrib><creatorcontrib>Dehelean, Cristina</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Journal of thermal analysis and calorimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Circioban, Denisa</au><au>Ledeţi, Ionuţ</au><au>Vlase, Gabriela</au><au>Ledeţi, Adriana</au><au>Axente, Carmen</au><au>Vlase, Titus</au><au>Dehelean, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics of heterogeneous-induced degradation for artesunate and artemether</atitle><jtitle>Journal of thermal analysis and calorimetry</jtitle><stitle>J Therm Anal Calorim</stitle><date>2018-10-01</date><risdate>2018</risdate><volume>134</volume><issue>1</issue><spage>749</spage><epage>756</epage><pages>749-756</pages><issn>1388-6150</issn><eissn>1588-2926</eissn><abstract>This paper presents the results obtained after the investigation of two artemisinin derived sesquiterpenes, namely artesunate and artemether, currently studied for their antitumor properties. 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| subjects | Analytical Chemistry Anticancer properties Chemistry Chemistry and Materials Science Degradation Fourier transforms Inorganic Chemistry Measurement Science and Instrumentation Organic chemistry Physical Chemistry Polymer Sciences Thermal stability Thermodynamic properties |
| title | Kinetics of heterogeneous-induced degradation for artesunate and artemether |
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