Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats

Increased levels of plasma cysteine predispose to obesity and metabolic disturbances. Our recent genetic analyses in spontaneously hypertensive rats (SHR) revealed mutated Folr1 (folate receptor 1) on chromosome 1 as a quantitative trait gene associated with reduced folate levels, hypercysteinemia a...

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Veröffentlicht in:	Physiological research 2018-01, Vol.67 (4), p.657-662
Hauptverfasser:	Šilhavý, J, Krijt, J, Sokolová, J, Zídek, V, Mlejnek, P, Šimáková, M, Škop, V, Trnovská, J, Oliyarnyk, O, Marková, I, Hüttl, M, Malínská, H, Kazdová, L, Liška, F, Kožich, V, Pravenec, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Alleles Amino acids Animals Animals, Congenic Chromosome 1 Chromosomes Cysteine Enzymes Folate Receptor 1 - physiology FOLH1 gene Folic acid FOLR1 gene Genes Genetic analysis Glucose metabolism Glutamate Carboxypeptidase II - physiology Homocysteine Hydrolase Hypertension Insulin Insulin resistance Lipid metabolism Lipids Male Metabolic syndrome Metabolic Syndrome - genetics Metabolic Syndrome - metabolism mRNA Obesity Oxidative Stress - physiology Physiology Plasma Prostate Rats Rats, Inbred BN Rats, Inbred SHR Rodents Small intestine Sulfur Vitamin B Vitamin deficiency
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