Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription
Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription. Dialysis patients require special consideration regarding analgesics, given their altered pharmacokinetic and pharmacodynamic profiles and increased potential for adverse reactions. Analgesic p...
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description | Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription.
Dialysis patients require special consideration regarding analgesics, given their altered pharmacokinetic and pharmacodynamic profiles and increased potential for adverse reactions.
Analgesic prescription patterns were investigated using data from the Dialysis Outcomes and Practice Patterns Study (DOPPS), with 3749 patients in 142 United States facilities studied between May 1996 and September 2001.
The proportion of patients prescribed any analgesic decreased from 30.2% to 24.3%; narcotic prescriptions decreased from 18.0% to 14.9%. The most commonly prescribed narcotics were propoxyphene/acetaminophen combinations (47.2%). Combinations containing acetaminophen were prescribed concurrently for 84.1% of patients on narcotics. About one half of prescriptions for narcotics, acetaminophen, and cyclooxygenase-2 (COX-2) agents were for 12months or more; one half of prescriptions for nonsteroidal anti-inflammatory drugs (NSAIDs) were for 8months or more. The proportion of patients prescribed analgesics varied by facility (mean ± SD = 27.9%± 18.9% for all analgesics, range 0% to 89.3%). Analgesic prescription was more likely among the elderly, women, and patients with cardiovascular disease (other than coronary artery disease or congestive heart failure), lung and psychiatric disease, cancer (other than skin), and recurrent cellulitis. Patients prescribed laxatives were almost twice as likely to be on a narcotic (odds ratio = 1.95, P < 0.0001). Analgesic prescription did not correlate with loss of residual renal function or hospitalization for a gastrointestinal disorder. Three-quarters of patients reporting moderate to very severe pain were not prescribed analgesics. Furthermore, 74% of patients with pain that interfered with work had no analgesic prescription.
Dialysis patients and providers may benefit from both refinement of existing guidelines and a renewed understanding regarding appropriate prescription of analgesics. |
doi_str_mv | 10.1111/j.1523-1755.2004.00658.x |
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Dialysis patients require special consideration regarding analgesics, given their altered pharmacokinetic and pharmacodynamic profiles and increased potential for adverse reactions.
Analgesic prescription patterns were investigated using data from the Dialysis Outcomes and Practice Patterns Study (DOPPS), with 3749 patients in 142 United States facilities studied between May 1996 and September 2001.
The proportion of patients prescribed any analgesic decreased from 30.2% to 24.3%; narcotic prescriptions decreased from 18.0% to 14.9%. The most commonly prescribed narcotics were propoxyphene/acetaminophen combinations (47.2%). Combinations containing acetaminophen were prescribed concurrently for 84.1% of patients on narcotics. About one half of prescriptions for narcotics, acetaminophen, and cyclooxygenase-2 (COX-2) agents were for 12months or more; one half of prescriptions for nonsteroidal anti-inflammatory drugs (NSAIDs) were for 8months or more. The proportion of patients prescribed analgesics varied by facility (mean ± SD = 27.9%± 18.9% for all analgesics, range 0% to 89.3%). Analgesic prescription was more likely among the elderly, women, and patients with cardiovascular disease (other than coronary artery disease or congestive heart failure), lung and psychiatric disease, cancer (other than skin), and recurrent cellulitis. Patients prescribed laxatives were almost twice as likely to be on a narcotic (odds ratio = 1.95, P < 0.0001). Analgesic prescription did not correlate with loss of residual renal function or hospitalization for a gastrointestinal disorder. Three-quarters of patients reporting moderate to very severe pain were not prescribed analgesics. Furthermore, 74% of patients with pain that interfered with work had no analgesic prescription.
Dialysis patients and providers may benefit from both refinement of existing guidelines and a renewed understanding regarding appropriate prescription of analgesics.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1111/j.1523-1755.2004.00658.x</identifier><identifier>PMID: 15149355</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetaminophen - therapeutic use ; Aged ; analgesics ; Analgesics - adverse effects ; Analgesics - therapeutic use ; Analgesics, Opioid - therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; Cyclooxygenase Inhibitors - therapeutic use ; Drug Prescriptions ; Female ; hemodialysis ; Humans ; Kidney - drug effects ; Kidney Failure, Chronic - drug therapy ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; narcotic analgesics ; Nephrology. Urinary tract diseases ; nonnarcotic analgesics ; Pain - drug therapy ; pain control ; prescription practices ; Prospective Studies ; Renal Dialysis ; United States</subject><ispartof>Kidney international, 2004-06, Vol.65 (6), p.2419-2425</ispartof><rights>2004 International Society of Nephrology</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-cc359c7684b07f96d501630e3bc3a6488fdef79b30bb58de45606b94b8822d9e3</citedby><cites>FETCH-LOGICAL-c499t-cc359c7684b07f96d501630e3bc3a6488fdef79b30bb58de45606b94b8822d9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210162811?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15835218$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15149355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bailie, George R.</creatorcontrib><creatorcontrib>Mason, Nancy A.</creatorcontrib><creatorcontrib>Bragg-Gresham, Jennifer L.</creatorcontrib><creatorcontrib>Gillespie, Brenda W.</creatorcontrib><creatorcontrib>Young, Eric W.</creatorcontrib><title>Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription.
Dialysis patients require special consideration regarding analgesics, given their altered pharmacokinetic and pharmacodynamic profiles and increased potential for adverse reactions.
Analgesic prescription patterns were investigated using data from the Dialysis Outcomes and Practice Patterns Study (DOPPS), with 3749 patients in 142 United States facilities studied between May 1996 and September 2001.
The proportion of patients prescribed any analgesic decreased from 30.2% to 24.3%; narcotic prescriptions decreased from 18.0% to 14.9%. The most commonly prescribed narcotics were propoxyphene/acetaminophen combinations (47.2%). Combinations containing acetaminophen were prescribed concurrently for 84.1% of patients on narcotics. About one half of prescriptions for narcotics, acetaminophen, and cyclooxygenase-2 (COX-2) agents were for 12months or more; one half of prescriptions for nonsteroidal anti-inflammatory drugs (NSAIDs) were for 8months or more. The proportion of patients prescribed analgesics varied by facility (mean ± SD = 27.9%± 18.9% for all analgesics, range 0% to 89.3%). Analgesic prescription was more likely among the elderly, women, and patients with cardiovascular disease (other than coronary artery disease or congestive heart failure), lung and psychiatric disease, cancer (other than skin), and recurrent cellulitis. Patients prescribed laxatives were almost twice as likely to be on a narcotic (odds ratio = 1.95, P < 0.0001). Analgesic prescription did not correlate with loss of residual renal function or hospitalization for a gastrointestinal disorder. Three-quarters of patients reporting moderate to very severe pain were not prescribed analgesics. Furthermore, 74% of patients with pain that interfered with work had no analgesic prescription.
Dialysis patients and providers may benefit from both refinement of existing guidelines and a renewed understanding regarding appropriate prescription of analgesics.</description><subject>Acetaminophen - therapeutic use</subject><subject>Aged</subject><subject>analgesics</subject><subject>Analgesics - adverse effects</subject><subject>Analgesics - therapeutic use</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cyclooxygenase Inhibitors - therapeutic use</subject><subject>Drug Prescriptions</subject><subject>Female</subject><subject>hemodialysis</subject><subject>Humans</subject><subject>Kidney - drug effects</subject><subject>Kidney Failure, Chronic - drug therapy</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>narcotic analgesics</subject><subject>Nephrology. Urinary tract diseases</subject><subject>nonnarcotic analgesics</subject><subject>Pain - drug therapy</subject><subject>pain control</subject><subject>prescription practices</subject><subject>Prospective Studies</subject><subject>Renal Dialysis</subject><subject>United States</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkF1vFCEUhonR2G31J2iIiZczwgCz4F1b60fSpJuo14SBMy2bXRiBMe2_l3E3tXdyQ-B9zht4EMKUtLSuD9uWio41dC1E2xHCW0J6Idv7Z2j1GDxHK0KkaDrB5Ak6zXlL6lkx8hKdUEG5YkKskD8PZncL2Vs8Jcg2-an4GPBkSoEUMjb7GG7xHeyj82b3kH1eMg-hZOwDLneAP91sNt8_4k0s9bZCeIwJz8FBelr5Cr0YzS7D6-N-hn5-vvpx-bW5vvny7fL8urFcqdJYy4Sy617ygaxH1TtBaM8IsMEy03MpRwfjWg2MDIOQDrjoST8oPkjZdU4BO0PvDr1Tir9myEVv45zqL7PuaO3qJKUVkgfIpphzglFPye9NetCU6EWx3urFpF5M6kWx_qtY39fRt8f-ediD-zd4dFqB90fAZGt2YzLB-vyEk0x0VFbuzYELpswJHgHOFRec1fzikEO19dtD0tlW7xacT2CLdtH__7V_AGuSpSg</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Bailie, George R.</creator><creator>Mason, Nancy A.</creator><creator>Bragg-Gresham, Jennifer L.</creator><creator>Gillespie, Brenda W.</creator><creator>Young, Eric W.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20040601</creationdate><title>Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription</title><author>Bailie, George R. ; Mason, Nancy A. ; Bragg-Gresham, Jennifer L. ; Gillespie, Brenda W. ; Young, Eric W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-cc359c7684b07f96d501630e3bc3a6488fdef79b30bb58de45606b94b8822d9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetaminophen - therapeutic use</topic><topic>Aged</topic><topic>analgesics</topic><topic>Analgesics - adverse effects</topic><topic>Analgesics - therapeutic use</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cyclooxygenase Inhibitors - therapeutic use</topic><topic>Drug Prescriptions</topic><topic>Female</topic><topic>hemodialysis</topic><topic>Humans</topic><topic>Kidney - drug effects</topic><topic>Kidney Failure, Chronic - drug therapy</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>narcotic analgesics</topic><topic>Nephrology. Urinary tract diseases</topic><topic>nonnarcotic analgesics</topic><topic>Pain - drug therapy</topic><topic>pain control</topic><topic>prescription practices</topic><topic>Prospective Studies</topic><topic>Renal Dialysis</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bailie, George R.</creatorcontrib><creatorcontrib>Mason, Nancy A.</creatorcontrib><creatorcontrib>Bragg-Gresham, Jennifer L.</creatorcontrib><creatorcontrib>Gillespie, Brenda W.</creatorcontrib><creatorcontrib>Young, Eric W.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bailie, George R.</au><au>Mason, Nancy A.</au><au>Bragg-Gresham, Jennifer L.</au><au>Gillespie, Brenda W.</au><au>Young, Eric W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>65</volume><issue>6</issue><spage>2419</spage><epage>2425</epage><pages>2419-2425</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription.
Dialysis patients require special consideration regarding analgesics, given their altered pharmacokinetic and pharmacodynamic profiles and increased potential for adverse reactions.
Analgesic prescription patterns were investigated using data from the Dialysis Outcomes and Practice Patterns Study (DOPPS), with 3749 patients in 142 United States facilities studied between May 1996 and September 2001.
The proportion of patients prescribed any analgesic decreased from 30.2% to 24.3%; narcotic prescriptions decreased from 18.0% to 14.9%. The most commonly prescribed narcotics were propoxyphene/acetaminophen combinations (47.2%). Combinations containing acetaminophen were prescribed concurrently for 84.1% of patients on narcotics. About one half of prescriptions for narcotics, acetaminophen, and cyclooxygenase-2 (COX-2) agents were for 12months or more; one half of prescriptions for nonsteroidal anti-inflammatory drugs (NSAIDs) were for 8months or more. The proportion of patients prescribed analgesics varied by facility (mean ± SD = 27.9%± 18.9% for all analgesics, range 0% to 89.3%). Analgesic prescription was more likely among the elderly, women, and patients with cardiovascular disease (other than coronary artery disease or congestive heart failure), lung and psychiatric disease, cancer (other than skin), and recurrent cellulitis. Patients prescribed laxatives were almost twice as likely to be on a narcotic (odds ratio = 1.95, P < 0.0001). Analgesic prescription did not correlate with loss of residual renal function or hospitalization for a gastrointestinal disorder. Three-quarters of patients reporting moderate to very severe pain were not prescribed analgesics. Furthermore, 74% of patients with pain that interfered with work had no analgesic prescription.
Dialysis patients and providers may benefit from both refinement of existing guidelines and a renewed understanding regarding appropriate prescription of analgesics.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15149355</pmid><doi>10.1111/j.1523-1755.2004.00658.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acetaminophen - therapeutic use Aged analgesics Analgesics - adverse effects Analgesics - therapeutic use Analgesics, Opioid - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Cyclooxygenase Inhibitors - therapeutic use Drug Prescriptions Female hemodialysis Humans Kidney - drug effects Kidney Failure, Chronic - drug therapy Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged narcotic analgesics Nephrology. Urinary tract diseases nonnarcotic analgesics Pain - drug therapy pain control prescription practices Prospective Studies Renal Dialysis United States |
title | Analgesic prescription patterns among hemodialysis patients in the DOPPS: Potential for underprescription |
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