A modified dialyzer with vitamin E and antioxidant defense parameters
A modified dialyzer with vitamin E and antioxidant defense parameters. Oxidative stress, increased lipid peroxidation, and decreased activity of antioxidant systems may contribute to the accelerated development of atherosclerosis in patients receiving hemodialysis therapy for chronic renal failure....
Gespeichert in:
| Veröffentlicht in: | Kidney international 2001-02, Vol.59 (S78), p.S144-S147 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S147 |
|---|---|
| container_issue | S78 |
| container_start_page | S144 |
| container_title | Kidney international |
| container_volume | 59 |
| creator | Mydlík, Miroslav Derzsiová, Katarína Rácz, Oliver Šipulová, Anna Lovásová, Eva Petrovičová, Jozefína |
| description | A modified dialyzer with vitamin E and antioxidant defense parameters.
Oxidative stress, increased lipid peroxidation, and decreased activity of antioxidant systems may contribute to the accelerated development of atherosclerosis in patients receiving hemodialysis therapy for chronic renal failure. We investigated the influence of vitamin E on antioxidant defense parameters in hemodialysis patients who were using a modified dialyzer.
In eight hemodialyzed patients, erythrocyte antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), plasma total antioxidant capacity (TAC), the concentration of plasma malondialdehyde (MDA), and vitamins A, E, and C were investigated. Each parameter was measured before and after hemodialysis. The study was divided into three periods. Each period lasted three weeks, and during this time, 10 hemodialyses were performed. The first and second periods were carried out using the conventional dialyzer, Terumo CL-S15, but during the second period, patients received vitamin E 400 mg perorally after each hemodialysis. The third period was carried out using a modified dialyzer with vitamin E, Terumo CL-E15. All hemodialyzed patients were treated by erythropoietin and received vitamin C 50 mg/day and pyridoxine 20 mg/day during the entire study.
The peroral administration of vitamin E led to a significant increase of serum vitamin E (22%), and no influence on other antioxidant defense parameters was found. The modified dialyzer with vitamin E led to a significant increase of serum vitamin E (33%) and TAC and to the significant decrease of plasma MDA.
The results of our study suggest that the modified dialyzer with vitamin E provided more effective antioxidant defense than peroral administration of vitamin E in our hemodialysis patients. |
| doi_str_mv | 10.1046/j.1523-1755.2001.59780144.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_210111435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0085253815477798</els_id><sourcerecordid>1012039231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-67ca6f505e9baff7b229cdf8bccb74ed8c83587fa929609f5b12b2b8100523503</originalsourceid><addsrcrecordid>eNqNkF1LwzAUhoMobk5_glL0ujVJmzbBqzHmBwy80euQJieYsbYz6ebmrzdjc956cTgc3vd8PQjdEZwRXJT384wwmqekYiyjGJOMiYpjUhTZ5gQNj9opGmLMWUpZzgfoIoQ5jrXI8TkaEEJKEcshmo6TpjPOOjCJcWqx_QaffLn-I1m7XjWuTaaJak2M3nUbZ2JODFhoAyRL5VUDPfhwic6sWgS4OuQRen-cvk2e09nr08tkPEt1wUmflpVWpWWYgaiVtVVNqdDG8lrruirAcM1zxiurBBUlFpbVhNa05gTj-BXD-Qjd7ucuffe5gtDLebfybVwpKcHxqyJn0fSwN2nfheDByqV3jfJbSbDcEZRzuaMkd5TkjqD8JSg3sfvmsGJVN2D-eg_IouF6b2hVv_JwNBSFoHlOoz7d6xBBrB14GbSDVoNxHnQvTef-dcgPYMKMPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>210111435</pqid></control><display><type>article</type><title>A modified dialyzer with vitamin E and antioxidant defense parameters</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Mydlík, Miroslav ; Derzsiová, Katarína ; Rácz, Oliver ; Šipulová, Anna ; Lovásová, Eva ; Petrovičová, Jozefína</creator><creatorcontrib>Mydlík, Miroslav ; Derzsiová, Katarína ; Rácz, Oliver ; Šipulová, Anna ; Lovásová, Eva ; Petrovičová, Jozefína</creatorcontrib><description>A modified dialyzer with vitamin E and antioxidant defense parameters.
Oxidative stress, increased lipid peroxidation, and decreased activity of antioxidant systems may contribute to the accelerated development of atherosclerosis in patients receiving hemodialysis therapy for chronic renal failure. We investigated the influence of vitamin E on antioxidant defense parameters in hemodialysis patients who were using a modified dialyzer.
In eight hemodialyzed patients, erythrocyte antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), plasma total antioxidant capacity (TAC), the concentration of plasma malondialdehyde (MDA), and vitamins A, E, and C were investigated. Each parameter was measured before and after hemodialysis. The study was divided into three periods. Each period lasted three weeks, and during this time, 10 hemodialyses were performed. The first and second periods were carried out using the conventional dialyzer, Terumo CL-S15, but during the second period, patients received vitamin E 400 mg perorally after each hemodialysis. The third period was carried out using a modified dialyzer with vitamin E, Terumo CL-E15. All hemodialyzed patients were treated by erythropoietin and received vitamin C 50 mg/day and pyridoxine 20 mg/day during the entire study.
The peroral administration of vitamin E led to a significant increase of serum vitamin E (22%), and no influence on other antioxidant defense parameters was found. The modified dialyzer with vitamin E led to a significant increase of serum vitamin E (33%) and TAC and to the significant decrease of plasma MDA.
The results of our study suggest that the modified dialyzer with vitamin E provided more effective antioxidant defense than peroral administration of vitamin E in our hemodialysis patients.</description><identifier>ISSN: 0085-2538</identifier><identifier>ISSN: 0098-6577</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1046/j.1523-1755.2001.59780144.x</identifier><identifier>PMID: 11169000</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Oral ; Antioxidants - administration & dosage ; Antioxidants - metabolism ; Arteriosclerosis - etiology ; chronic renal failure ; dialysis membrane with vitamin E ; Female ; Humans ; Kidneys, Artificial ; Lipid Peroxidation ; Male ; Membranes, Artificial ; Middle Aged ; oral vitamin supplements ; oxidative stress ; Oxidative Stress - drug effects ; Renal Dialysis - adverse effects ; Vitamin E - administration & dosage ; Vitamin E - blood</subject><ispartof>Kidney international, 2001-02, Vol.59 (S78), p.S144-S147</ispartof><rights>2001 International Society of Nephrology</rights><rights>Copyright Nature Publishing Group Feb 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-67ca6f505e9baff7b229cdf8bccb74ed8c83587fa929609f5b12b2b8100523503</citedby><cites>FETCH-LOGICAL-c481t-67ca6f505e9baff7b229cdf8bccb74ed8c83587fa929609f5b12b2b8100523503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210111435?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11169000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mydlík, Miroslav</creatorcontrib><creatorcontrib>Derzsiová, Katarína</creatorcontrib><creatorcontrib>Rácz, Oliver</creatorcontrib><creatorcontrib>Šipulová, Anna</creatorcontrib><creatorcontrib>Lovásová, Eva</creatorcontrib><creatorcontrib>Petrovičová, Jozefína</creatorcontrib><title>A modified dialyzer with vitamin E and antioxidant defense parameters</title><title>Kidney international</title><addtitle>Kidney Int Suppl</addtitle><description>A modified dialyzer with vitamin E and antioxidant defense parameters.
Oxidative stress, increased lipid peroxidation, and decreased activity of antioxidant systems may contribute to the accelerated development of atherosclerosis in patients receiving hemodialysis therapy for chronic renal failure. We investigated the influence of vitamin E on antioxidant defense parameters in hemodialysis patients who were using a modified dialyzer.
In eight hemodialyzed patients, erythrocyte antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), plasma total antioxidant capacity (TAC), the concentration of plasma malondialdehyde (MDA), and vitamins A, E, and C were investigated. Each parameter was measured before and after hemodialysis. The study was divided into three periods. Each period lasted three weeks, and during this time, 10 hemodialyses were performed. The first and second periods were carried out using the conventional dialyzer, Terumo CL-S15, but during the second period, patients received vitamin E 400 mg perorally after each hemodialysis. The third period was carried out using a modified dialyzer with vitamin E, Terumo CL-E15. All hemodialyzed patients were treated by erythropoietin and received vitamin C 50 mg/day and pyridoxine 20 mg/day during the entire study.
The peroral administration of vitamin E led to a significant increase of serum vitamin E (22%), and no influence on other antioxidant defense parameters was found. The modified dialyzer with vitamin E led to a significant increase of serum vitamin E (33%) and TAC and to the significant decrease of plasma MDA.
The results of our study suggest that the modified dialyzer with vitamin E provided more effective antioxidant defense than peroral administration of vitamin E in our hemodialysis patients.</description><subject>Administration, Oral</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - metabolism</subject><subject>Arteriosclerosis - etiology</subject><subject>chronic renal failure</subject><subject>dialysis membrane with vitamin E</subject><subject>Female</subject><subject>Humans</subject><subject>Kidneys, Artificial</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Membranes, Artificial</subject><subject>Middle Aged</subject><subject>oral vitamin supplements</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Renal Dialysis - adverse effects</subject><subject>Vitamin E - administration & dosage</subject><subject>Vitamin E - blood</subject><issn>0085-2538</issn><issn>0098-6577</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkF1LwzAUhoMobk5_glL0ujVJmzbBqzHmBwy80euQJieYsbYz6ebmrzdjc956cTgc3vd8PQjdEZwRXJT384wwmqekYiyjGJOMiYpjUhTZ5gQNj9opGmLMWUpZzgfoIoQ5jrXI8TkaEEJKEcshmo6TpjPOOjCJcWqx_QaffLn-I1m7XjWuTaaJak2M3nUbZ2JODFhoAyRL5VUDPfhwic6sWgS4OuQRen-cvk2e09nr08tkPEt1wUmflpVWpWWYgaiVtVVNqdDG8lrruirAcM1zxiurBBUlFpbVhNa05gTj-BXD-Qjd7ucuffe5gtDLebfybVwpKcHxqyJn0fSwN2nfheDByqV3jfJbSbDcEZRzuaMkd5TkjqD8JSg3sfvmsGJVN2D-eg_IouF6b2hVv_JwNBSFoHlOoz7d6xBBrB14GbSDVoNxHnQvTef-dcgPYMKMPw</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Mydlík, Miroslav</creator><creator>Derzsiová, Katarína</creator><creator>Rácz, Oliver</creator><creator>Šipulová, Anna</creator><creator>Lovásová, Eva</creator><creator>Petrovičová, Jozefína</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20010201</creationdate><title>A modified dialyzer with vitamin E and antioxidant defense parameters</title><author>Mydlík, Miroslav ; Derzsiová, Katarína ; Rácz, Oliver ; Šipulová, Anna ; Lovásová, Eva ; Petrovičová, Jozefína</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-67ca6f505e9baff7b229cdf8bccb74ed8c83587fa929609f5b12b2b8100523503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - metabolism</topic><topic>Arteriosclerosis - etiology</topic><topic>chronic renal failure</topic><topic>dialysis membrane with vitamin E</topic><topic>Female</topic><topic>Humans</topic><topic>Kidneys, Artificial</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Membranes, Artificial</topic><topic>Middle Aged</topic><topic>oral vitamin supplements</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Renal Dialysis - adverse effects</topic><topic>Vitamin E - administration & dosage</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mydlík, Miroslav</creatorcontrib><creatorcontrib>Derzsiová, Katarína</creatorcontrib><creatorcontrib>Rácz, Oliver</creatorcontrib><creatorcontrib>Šipulová, Anna</creatorcontrib><creatorcontrib>Lovásová, Eva</creatorcontrib><creatorcontrib>Petrovičová, Jozefína</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mydlík, Miroslav</au><au>Derzsiová, Katarína</au><au>Rácz, Oliver</au><au>Šipulová, Anna</au><au>Lovásová, Eva</au><au>Petrovičová, Jozefína</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A modified dialyzer with vitamin E and antioxidant defense parameters</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int Suppl</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>59</volume><issue>S78</issue><spage>S144</spage><epage>S147</epage><pages>S144-S147</pages><issn>0085-2538</issn><issn>0098-6577</issn><eissn>1523-1755</eissn><abstract>A modified dialyzer with vitamin E and antioxidant defense parameters.
Oxidative stress, increased lipid peroxidation, and decreased activity of antioxidant systems may contribute to the accelerated development of atherosclerosis in patients receiving hemodialysis therapy for chronic renal failure. We investigated the influence of vitamin E on antioxidant defense parameters in hemodialysis patients who were using a modified dialyzer.
In eight hemodialyzed patients, erythrocyte antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), plasma total antioxidant capacity (TAC), the concentration of plasma malondialdehyde (MDA), and vitamins A, E, and C were investigated. Each parameter was measured before and after hemodialysis. The study was divided into three periods. Each period lasted three weeks, and during this time, 10 hemodialyses were performed. The first and second periods were carried out using the conventional dialyzer, Terumo CL-S15, but during the second period, patients received vitamin E 400 mg perorally after each hemodialysis. The third period was carried out using a modified dialyzer with vitamin E, Terumo CL-E15. All hemodialyzed patients were treated by erythropoietin and received vitamin C 50 mg/day and pyridoxine 20 mg/day during the entire study.
The peroral administration of vitamin E led to a significant increase of serum vitamin E (22%), and no influence on other antioxidant defense parameters was found. The modified dialyzer with vitamin E led to a significant increase of serum vitamin E (33%) and TAC and to the significant decrease of plasma MDA.
The results of our study suggest that the modified dialyzer with vitamin E provided more effective antioxidant defense than peroral administration of vitamin E in our hemodialysis patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11169000</pmid><doi>10.1046/j.1523-1755.2001.59780144.x</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0085-2538 |
| ispartof | Kidney international, 2001-02, Vol.59 (S78), p.S144-S147 |
| issn | 0085-2538 0098-6577 1523-1755 |
| language | eng |
| recordid | cdi_proquest_journals_210111435 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Administration, Oral Antioxidants - administration & dosage Antioxidants - metabolism Arteriosclerosis - etiology chronic renal failure dialysis membrane with vitamin E Female Humans Kidneys, Artificial Lipid Peroxidation Male Membranes, Artificial Middle Aged oral vitamin supplements oxidative stress Oxidative Stress - drug effects Renal Dialysis - adverse effects Vitamin E - administration & dosage Vitamin E - blood |
| title | A modified dialyzer with vitamin E and antioxidant defense parameters |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A26%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20modified%20dialyzer%20with%20vitamin%20E%20and%20antioxidant%20defense%20parameters&rft.jtitle=Kidney%20international&rft.au=Mydl%C3%ADk,%20Miroslav&rft.date=2001-02-01&rft.volume=59&rft.issue=S78&rft.spage=S144&rft.epage=S147&rft.pages=S144-S147&rft.issn=0085-2538&rft.eissn=1523-1755&rft_id=info:doi/10.1046/j.1523-1755.2001.59780144.x&rft_dat=%3Cproquest_cross%3E1012039231%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=210111435&rft_id=info:pmid/11169000&rft_els_id=S0085253815477798&rfr_iscdi=true |