Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury

This study tests the hypothesis that plasminogen activator inhibitor-1 (PAI-1) contributes to aldosterone-induced renal and cardiac injury. The effects of 12-week aldosterone (2.8 μg/day)/salt (1% drinking water) versus vehicle/salt on renal and cardiac histology and mRNA expression were determined...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Kidney international 2006-03, Vol.69 (6), p.1064-1072
Hauptverfasser:	Ma, J., Weisberg, A., Griffin, J.P., Vaughan, D.E., Fogo, A.B., Brown, N.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - urine aldosterone Aldosterone - adverse effects Aldosterone - pharmacology angiotensin Animals Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Chemokine CCL2 - analysis Chemokine CCL2 - genetics Collagen - analysis Collagen - genetics Fibronectins - analysis Fibronectins - genetics Gene Expression Glomerulonephritis Glomerulonephritis - chemically induced Glomerulonephritis - physiopathology Glomerulonephritis - prevention & control Glomerulonephritis - urine Hemodynamics - physiology Kidney Glomerulus - chemistry Kidney Glomerulus - drug effects Kidney Glomerulus - pathology Kidney Glomerulus - physiopathology Macrophages - pathology Male Medical sciences Mice Mice, Inbred C57BL Mice, Inbred Strains Myocardium - chemistry Myocardium - pathology Nephrectomy Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Osteopontin Plasminogen Activator Inhibitor 1 - deficiency Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - physiology plasminogen activator inhibitor-1 RNA, Messenger - analysis Sialoglycoproteins - analysis Sialoglycoproteins - genetics Sodium - urine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!