Protein uptake disturbs collagen homeostasis in proximal tubule-derived cells

Protein uptake disturbs collagen homeostasis in proximal tubule-derived cells. Interstitial fibrosis is of major importance for the deterioration of renal function, leading to uremia. Interaction of filtered proteins with proximal tubular cells is important for the onset and development of tubuloint...

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Veröffentlicht in:	Kidney international 2003-05, Vol.63 (S84), p.S103-S109
Hauptverfasser:	Wohlfarth, Verena, Drumm, Karina, Mildenberger, Sigrid, Freudinger, Ruth, Gekle, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	albumin Albumins - pharmacokinetics Animals AP1 Blotting, Western collagen Collagen - analysis Collagen - metabolism Collagenases endocytosis Enzyme-Linked Immunosorbent Assay gelatinase Gelatinases - metabolism Genes, Reporter Homeostasis - physiology Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - metabolism LLC-PK1 Cells NF-κB Opossums PKA PKC Proline - pharmacokinetics proximal tubule SEAP-reporter-assay Signal Transduction - physiology Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - genetics Swine
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