Urinary bisphenol A levels in Turkish girls with premature thelarche
There is a growing concern over the timing of pubertal breast development and its possible association with exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA). BPA is abundantly used to harden plastics. The aim of this study was to investigate the relation between premature...
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| Veröffentlicht in: | Human & experimental toxicology 2018-10, Vol.37 (10), p.1007-1016 |
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| creator | Durmaz, E Asci, A Erkekoglu, P Balcı, A Bircan, I Koçer-Gumusel, B |
| description | There is a growing concern over the timing of pubertal breast development and its possible association with exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA). BPA is abundantly used to harden plastics. The aim of this study was to investigate the relation between premature thelarche (PT) and BPA by comparing the urinary BPA levels of PT girls with those of healthy subjects. Twenty-five newly diagnosed nonobese PT subjects (aged 4–8 years) who were admitted to the Pediatric Endocrinology Department at Akdeniz University were recruited. The control group composed of 25 age-matched girls without PT and other endocrine disorders. Urinary BPA levels were measured by high pressure liquid chromatography. The median urinary concentrations of BPA were found to be significantly higher in the PT group compared to the healthy control group (3.2 vs. 1.62 μg/g creatinine, p < 0.05). We observed a weak positive correlation between uterus volume and urinary BPA levels. There was a weak correlation between estradiol and urinary BPA levels (r = 0.166; p = 0.37); and luteinizing hormone and urinary BPA levels (r = 0.291; p = 0.08) of PT girls. Our results suggest that exposure to BPA might be one of the underlying factors of early breast development in prepubertal girls and EDCs may be considered as one of the etiological factors in the development of PT. |
| doi_str_mv | 10.1177/0960327118756720 |
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BPA is abundantly used to harden plastics. The aim of this study was to investigate the relation between premature thelarche (PT) and BPA by comparing the urinary BPA levels of PT girls with those of healthy subjects. Twenty-five newly diagnosed nonobese PT subjects (aged 4–8 years) who were admitted to the Pediatric Endocrinology Department at Akdeniz University were recruited. The control group composed of 25 age-matched girls without PT and other endocrine disorders. Urinary BPA levels were measured by high pressure liquid chromatography. The median urinary concentrations of BPA were found to be significantly higher in the PT group compared to the healthy control group (3.2 vs. 1.62 μg/g creatinine, p < 0.05). We observed a weak positive correlation between uterus volume and urinary BPA levels. There was a weak correlation between estradiol and urinary BPA levels (r = 0.166; p = 0.37); and luteinizing hormone and urinary BPA levels (r = 0.291; p = 0.08) of PT girls. Our results suggest that exposure to BPA might be one of the underlying factors of early breast development in prepubertal girls and EDCs may be considered as one of the etiological factors in the development of PT.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327118756720</identifier><identifier>PMID: 29405766</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>17β-Estradiol ; Benzhydryl Compounds - urine ; Bisphenol A ; Breast - growth & development ; Case-Control Studies ; Child ; Child, Preschool ; Chromatography, High Pressure Liquid ; Creatinine ; Creatinine - urine ; Endocrine disorders ; Endocrine disruptors ; Endocrine Disruptors - urine ; Endocrinology ; Estradiol - blood ; Estradiol - urine ; Etiology ; Exposure ; Female ; Girls ; High performance liquid chromatography ; High pressure ; Humans ; Limit of Detection ; Liquid chromatography ; Luteinizing hormone ; Luteinizing Hormone - blood ; Luteinizing Hormone - urine ; Organic chemistry ; Phenols ; Phenols - urine ; Polymers ; Puberty, Precocious - urine ; Sex hormones ; Thyrotropin - blood ; Turkey ; Uterus</subject><ispartof>Human & experimental toxicology, 2018-10, Vol.37 (10), p.1007-1016</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-cdfc69d14fe3675e05c5159246e56a974c297c7678a2a404395def9f7dd7c1d43</citedby><cites>FETCH-LOGICAL-c365t-cdfc69d14fe3675e05c5159246e56a974c297c7678a2a404395def9f7dd7c1d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327118756720$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327118756720$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327118756720?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29405766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durmaz, E</creatorcontrib><creatorcontrib>Asci, A</creatorcontrib><creatorcontrib>Erkekoglu, P</creatorcontrib><creatorcontrib>Balcı, A</creatorcontrib><creatorcontrib>Bircan, I</creatorcontrib><creatorcontrib>Koçer-Gumusel, B</creatorcontrib><title>Urinary bisphenol A levels in Turkish girls with premature thelarche</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>There is a growing concern over the timing of pubertal breast development and its possible association with exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA). BPA is abundantly used to harden plastics. The aim of this study was to investigate the relation between premature thelarche (PT) and BPA by comparing the urinary BPA levels of PT girls with those of healthy subjects. Twenty-five newly diagnosed nonobese PT subjects (aged 4–8 years) who were admitted to the Pediatric Endocrinology Department at Akdeniz University were recruited. The control group composed of 25 age-matched girls without PT and other endocrine disorders. Urinary BPA levels were measured by high pressure liquid chromatography. The median urinary concentrations of BPA were found to be significantly higher in the PT group compared to the healthy control group (3.2 vs. 1.62 μg/g creatinine, p < 0.05). We observed a weak positive correlation between uterus volume and urinary BPA levels. There was a weak correlation between estradiol and urinary BPA levels (r = 0.166; p = 0.37); and luteinizing hormone and urinary BPA levels (r = 0.291; p = 0.08) of PT girls. Our results suggest that exposure to BPA might be one of the underlying factors of early breast development in prepubertal girls and EDCs may be considered as one of the etiological factors in the development of PT.</description><subject>17β-Estradiol</subject><subject>Benzhydryl Compounds - urine</subject><subject>Bisphenol A</subject><subject>Breast - growth & development</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Creatinine</subject><subject>Creatinine - urine</subject><subject>Endocrine disorders</subject><subject>Endocrine disruptors</subject><subject>Endocrine Disruptors - urine</subject><subject>Endocrinology</subject><subject>Estradiol - blood</subject><subject>Estradiol - urine</subject><subject>Etiology</subject><subject>Exposure</subject><subject>Female</subject><subject>Girls</subject><subject>High performance liquid chromatography</subject><subject>High pressure</subject><subject>Humans</subject><subject>Limit of Detection</subject><subject>Liquid chromatography</subject><subject>Luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - urine</subject><subject>Organic chemistry</subject><subject>Phenols</subject><subject>Phenols - urine</subject><subject>Polymers</subject><subject>Puberty, Precocious - urine</subject><subject>Sex hormones</subject><subject>Thyrotropin - blood</subject><subject>Turkey</subject><subject>Uterus</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Lw0AQxRdRbK3ePcmC5-jsZj-6x1I_oeClPYftZtKkpkncTRT_exNaFQRPAzO_9x7zCLlkcMOY1rdgFMRcMzbVUmkOR2TMhNYRGIiPyXg4R8N9RM5C2AKAMpKdkhE3AqRWakzuVr6orP-k6yI0OVZ1SWe0xHcsAy0quuz8axFyuil8v_go2pw2Hne27TzSNsfSepfjOTnJbBnw4jAnZPVwv5w_RYuXx-f5bBG5WMk2cmnmlEmZyDBWWiJIJ5k0XCiUyhotHDfaaaWnllsBIjYyxcxkOk21Y6mIJ-R679v4-q3D0CbbuvNVH5lwBsC4kVPeU7CnnK9D8JgljS92_Y8Jg2SoLflbWy-5Ohh36x2mP4Lvnnog2gPBbvA39V_DL6loc5s</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Durmaz, E</creator><creator>Asci, A</creator><creator>Erkekoglu, P</creator><creator>Balcı, A</creator><creator>Bircan, I</creator><creator>Koçer-Gumusel, B</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>SOI</scope></search><sort><creationdate>201810</creationdate><title>Urinary bisphenol A levels in Turkish girls with premature thelarche</title><author>Durmaz, E ; Asci, A ; Erkekoglu, P ; Balcı, A ; Bircan, I ; Koçer-Gumusel, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-cdfc69d14fe3675e05c5159246e56a974c297c7678a2a404395def9f7dd7c1d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>17β-Estradiol</topic><topic>Benzhydryl Compounds - urine</topic><topic>Bisphenol A</topic><topic>Breast - growth & development</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Creatinine</topic><topic>Creatinine - urine</topic><topic>Endocrine disorders</topic><topic>Endocrine disruptors</topic><topic>Endocrine Disruptors - urine</topic><topic>Endocrinology</topic><topic>Estradiol - blood</topic><topic>Estradiol - urine</topic><topic>Etiology</topic><topic>Exposure</topic><topic>Female</topic><topic>Girls</topic><topic>High performance liquid chromatography</topic><topic>High pressure</topic><topic>Humans</topic><topic>Limit of Detection</topic><topic>Liquid chromatography</topic><topic>Luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - urine</topic><topic>Organic chemistry</topic><topic>Phenols</topic><topic>Phenols - urine</topic><topic>Polymers</topic><topic>Puberty, Precocious - urine</topic><topic>Sex hormones</topic><topic>Thyrotropin - blood</topic><topic>Turkey</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durmaz, E</creatorcontrib><creatorcontrib>Asci, A</creatorcontrib><creatorcontrib>Erkekoglu, P</creatorcontrib><creatorcontrib>Balcı, A</creatorcontrib><creatorcontrib>Bircan, I</creatorcontrib><creatorcontrib>Koçer-Gumusel, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Durmaz, E</au><au>Asci, A</au><au>Erkekoglu, P</au><au>Balcı, A</au><au>Bircan, I</au><au>Koçer-Gumusel, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary bisphenol A levels in Turkish girls with premature thelarche</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2018-10</date><risdate>2018</risdate><volume>37</volume><issue>10</issue><spage>1007</spage><epage>1016</epage><pages>1007-1016</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>There is a growing concern over the timing of pubertal breast development and its possible association with exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA). BPA is abundantly used to harden plastics. The aim of this study was to investigate the relation between premature thelarche (PT) and BPA by comparing the urinary BPA levels of PT girls with those of healthy subjects. Twenty-five newly diagnosed nonobese PT subjects (aged 4–8 years) who were admitted to the Pediatric Endocrinology Department at Akdeniz University were recruited. The control group composed of 25 age-matched girls without PT and other endocrine disorders. Urinary BPA levels were measured by high pressure liquid chromatography. The median urinary concentrations of BPA were found to be significantly higher in the PT group compared to the healthy control group (3.2 vs. 1.62 μg/g creatinine, p < 0.05). We observed a weak positive correlation between uterus volume and urinary BPA levels. There was a weak correlation between estradiol and urinary BPA levels (r = 0.166; p = 0.37); and luteinizing hormone and urinary BPA levels (r = 0.291; p = 0.08) of PT girls. Our results suggest that exposure to BPA might be one of the underlying factors of early breast development in prepubertal girls and EDCs may be considered as one of the etiological factors in the development of PT.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29405766</pmid><doi>10.1177/0960327118756720</doi><tpages>10</tpages></addata></record> |
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| ispartof | Human & experimental toxicology, 2018-10, Vol.37 (10), p.1007-1016 |
| issn | 0960-3271 1477-0903 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | 17β-Estradiol Benzhydryl Compounds - urine Bisphenol A Breast - growth & development Case-Control Studies Child Child, Preschool Chromatography, High Pressure Liquid Creatinine Creatinine - urine Endocrine disorders Endocrine disruptors Endocrine Disruptors - urine Endocrinology Estradiol - blood Estradiol - urine Etiology Exposure Female Girls High performance liquid chromatography High pressure Humans Limit of Detection Liquid chromatography Luteinizing hormone Luteinizing Hormone - blood Luteinizing Hormone - urine Organic chemistry Phenols Phenols - urine Polymers Puberty, Precocious - urine Sex hormones Thyrotropin - blood Turkey Uterus |
| title | Urinary bisphenol A levels in Turkish girls with premature thelarche |
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