Relationship between the Triglyceride Glucose Index and the Presence and Fibrosis of Nonalcoholic Fatty Liver Disease in Korean Adults

Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2018-07, Vol.67 (Supplement_1)
Hauptverfasser: KIM, MIN KYUNG, KIM, JUNG HYE, PARK, KAHUI, LEE, SANG BAE, NAM, JI SUN, KANG, SHINAE, PARK, JONG SUK, AHN, CHUL WOO, KIM, YU SIK
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container_issue Supplement_1
container_start_page
container_title Diabetes (New York, N.Y.)
container_volume 67
creator KIM, MIN KYUNG
KIM, JUNG HYE
PARK, KAHUI
LEE, SANG BAE
NAM, JI SUN
KANG, SHINAE
PARK, JONG SUK
AHN, CHUL WOO
KIM, YU SIK
description Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults. Methods: In total, 5158 participants who underwent ultrasonography in a health promotion center were enrolled. Anthropometric profiles and multiple metabolic risk factors were measured. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2], and the insulin resistance index of homeostasis model assessment (HOMA-IR) was estimated. NAFLD was diagnosed by ultrasonography, and degree of liver fibrosis was assessed by NAFLD fibrosis score (NFS). Significant liver fibrosis was defined as NFS ≥ -1.5. Results: All subjects were stratified into four groups based on their TyG indices. Significant differences were observed in metabolic parameters among the groups, and the prevalence of NAFLD and liver fibrosis by NFS significantly increased with increasing TyG index. When classifying the severity of NAFLD into three groups, there was a significant correlation between the severity of NAFLD and the TyG index. In the logistic regression analysis after adjustment for multiple risk factors, the odds ratio for the prevalence of liver fibrosis, when comparing the highest and lowest quartiles of the TyG index was 1.92 (95% CI: 1.46-2.53; P for trend < 0.01); the odds ratio for the prevalence of liver fibrosis, when comparing the highest and lowest quartiles of HOMA-IR was 2.92 (95% CI: 1.12-2.40; P for trend
doi_str_mv 10.2337/db18-612-P
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Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults. Methods: In total, 5158 participants who underwent ultrasonography in a health promotion center were enrolled. Anthropometric profiles and multiple metabolic risk factors were measured. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2], and the insulin resistance index of homeostasis model assessment (HOMA-IR) was estimated. NAFLD was diagnosed by ultrasonography, and degree of liver fibrosis was assessed by NAFLD fibrosis score (NFS). Significant liver fibrosis was defined as NFS ≥ -1.5. Results: All subjects were stratified into four groups based on their TyG indices. Significant differences were observed in metabolic parameters among the groups, and the prevalence of NAFLD and liver fibrosis by NFS significantly increased with increasing TyG index. When classifying the severity of NAFLD into three groups, there was a significant correlation between the severity of NAFLD and the TyG index. In the logistic regression analysis after adjustment for multiple risk factors, the odds ratio for the prevalence of liver fibrosis, when comparing the highest and lowest quartiles of the TyG index was 1.92 (95% CI: 1.46-2.53; P for trend &lt; 0.01); the odds ratio for the prevalence of liver fibrosis, when comparing the highest and lowest quartiles of HOMA-IR was 2.92 (95% CI: 1.12-2.40; P for trend &lt;0.01). Conclusion: There is a significant association between the TyG index and liver fibrosis of NAFLD, but HOMA-IR was superior to TyG index for predicting liver fibrosis in NAFLD patients.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db18-612-P</identifier><language>eng</language><publisher>New York: American Diabetes Association</publisher><subject>Adults ; Fasting ; Fatty liver ; Fibrosis ; Glucose ; Homeostasis ; Insulin ; Insulin resistance ; Liver diseases ; Oils &amp; fats ; Risk factors ; Triglycerides ; Ultrasound</subject><ispartof>Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)</ispartof><rights>Copyright American Diabetes Association Jul 1, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1041-c867d75225f68714d21b9d9fbd96b93ceca7748b40754e94dc76de1bfa7cb563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>KIM, MIN KYUNG</creatorcontrib><creatorcontrib>KIM, JUNG HYE</creatorcontrib><creatorcontrib>PARK, KAHUI</creatorcontrib><creatorcontrib>LEE, SANG BAE</creatorcontrib><creatorcontrib>NAM, JI SUN</creatorcontrib><creatorcontrib>KANG, SHINAE</creatorcontrib><creatorcontrib>PARK, JONG SUK</creatorcontrib><creatorcontrib>AHN, CHUL WOO</creatorcontrib><creatorcontrib>KIM, YU SIK</creatorcontrib><title>Relationship between the Triglyceride Glucose Index and the Presence and Fibrosis of Nonalcoholic Fatty Liver Disease in Korean Adults</title><title>Diabetes (New York, N.Y.)</title><description>Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults. Methods: In total, 5158 participants who underwent ultrasonography in a health promotion center were enrolled. Anthropometric profiles and multiple metabolic risk factors were measured. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2], and the insulin resistance index of homeostasis model assessment (HOMA-IR) was estimated. NAFLD was diagnosed by ultrasonography, and degree of liver fibrosis was assessed by NAFLD fibrosis score (NFS). Significant liver fibrosis was defined as NFS ≥ -1.5. Results: All subjects were stratified into four groups based on their TyG indices. Significant differences were observed in metabolic parameters among the groups, and the prevalence of NAFLD and liver fibrosis by NFS significantly increased with increasing TyG index. When classifying the severity of NAFLD into three groups, there was a significant correlation between the severity of NAFLD and the TyG index. In the logistic regression analysis after adjustment for multiple risk factors, the odds ratio for the prevalence of liver fibrosis, when comparing the highest and lowest quartiles of the TyG index was 1.92 (95% CI: 1.46-2.53; P for trend &lt; 0.01); the odds ratio for the prevalence of liver fibrosis, when comparing the highest and lowest quartiles of HOMA-IR was 2.92 (95% CI: 1.12-2.40; P for trend &lt;0.01). Conclusion: There is a significant association between the TyG index and liver fibrosis of NAFLD, but HOMA-IR was superior to TyG index for predicting liver fibrosis in NAFLD patients.</description><subject>Adults</subject><subject>Fasting</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Liver diseases</subject><subject>Oils &amp; fats</subject><subject>Risk factors</subject><subject>Triglycerides</subject><subject>Ultrasound</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNotkM1KAzEURoMoWKsbnyDgThhNJjOTybJUW4tFi3ThLuTnjk0Zk5pM1b6Az-3Uyl1c-Dh83HsQuqTkJmeM31pN66yiebY4QgMqmMhYzl-P0YCQPqRc8FN0ltKaEFL1M0A_L9CqzgWfVm6DNXRfAB53K8DL6N7anYHoLOBpuzUhAZ55C99YefuHLCIk8Ab-gonTMSSXcGjwU_CqNWEVWmfwRHXdDs_dJ0R85xKovsd5_BgiKI9Hdtt26RydNKpNcPG_h2g5uV-OH7L583Q2Hs0zQ0lBM1NX3PIyz8umqjktbE61sKLRVlRaMANGcV7UuiC8LEAU1vDKAtWN4kaXFRuiq0PtJoaPLaROrsM29rcmmRMhRE1LRnvq-kCZ_qEUoZGb6N5V3ElK5F6z3GuWvWa5YL_F5HGi</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>KIM, MIN KYUNG</creator><creator>KIM, JUNG HYE</creator><creator>PARK, KAHUI</creator><creator>LEE, SANG BAE</creator><creator>NAM, JI SUN</creator><creator>KANG, SHINAE</creator><creator>PARK, JONG SUK</creator><creator>AHN, CHUL WOO</creator><creator>KIM, YU SIK</creator><general>American Diabetes Association</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20180701</creationdate><title>Relationship between the Triglyceride Glucose Index and the Presence and Fibrosis of Nonalcoholic Fatty Liver Disease in Korean Adults</title><author>KIM, MIN KYUNG ; KIM, JUNG HYE ; PARK, KAHUI ; LEE, SANG BAE ; NAM, JI SUN ; KANG, SHINAE ; PARK, JONG SUK ; AHN, CHUL WOO ; KIM, YU SIK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1041-c867d75225f68714d21b9d9fbd96b93ceca7748b40754e94dc76de1bfa7cb563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Fasting</topic><topic>Fatty liver</topic><topic>Fibrosis</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Liver diseases</topic><topic>Oils &amp; fats</topic><topic>Risk factors</topic><topic>Triglycerides</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIM, MIN KYUNG</creatorcontrib><creatorcontrib>KIM, JUNG HYE</creatorcontrib><creatorcontrib>PARK, KAHUI</creatorcontrib><creatorcontrib>LEE, SANG BAE</creatorcontrib><creatorcontrib>NAM, JI SUN</creatorcontrib><creatorcontrib>KANG, SHINAE</creatorcontrib><creatorcontrib>PARK, JONG SUK</creatorcontrib><creatorcontrib>AHN, CHUL WOO</creatorcontrib><creatorcontrib>KIM, YU SIK</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIM, MIN KYUNG</au><au>KIM, JUNG HYE</au><au>PARK, KAHUI</au><au>LEE, SANG BAE</au><au>NAM, JI SUN</au><au>KANG, SHINAE</au><au>PARK, JONG SUK</au><au>AHN, CHUL WOO</au><au>KIM, YU SIK</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between the Triglyceride Glucose Index and the Presence and Fibrosis of Nonalcoholic Fatty Liver Disease in Korean Adults</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><date>2018-07-01</date><risdate>2018</risdate><volume>67</volume><issue>Supplement_1</issue><issn>0012-1797</issn><eissn>1939-327X</eissn><abstract>Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults. Methods: In total, 5158 participants who underwent ultrasonography in a health promotion center were enrolled. Anthropometric profiles and multiple metabolic risk factors were measured. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2], and the insulin resistance index of homeostasis model assessment (HOMA-IR) was estimated. NAFLD was diagnosed by ultrasonography, and degree of liver fibrosis was assessed by NAFLD fibrosis score (NFS). Significant liver fibrosis was defined as NFS ≥ -1.5. Results: All subjects were stratified into four groups based on their TyG indices. Significant differences were observed in metabolic parameters among the groups, and the prevalence of NAFLD and liver fibrosis by NFS significantly increased with increasing TyG index. When classifying the severity of NAFLD into three groups, there was a significant correlation between the severity of NAFLD and the TyG index. In the logistic regression analysis after adjustment for multiple risk factors, the odds ratio for the prevalence of liver fibrosis, when comparing the highest and lowest quartiles of the TyG index was 1.92 (95% CI: 1.46-2.53; P for trend &lt; 0.01); the odds ratio for the prevalence of liver fibrosis, when comparing the highest and lowest quartiles of HOMA-IR was 2.92 (95% CI: 1.12-2.40; P for trend &lt;0.01). Conclusion: There is a significant association between the TyG index and liver fibrosis of NAFLD, but HOMA-IR was superior to TyG index for predicting liver fibrosis in NAFLD patients.</abstract><cop>New York</cop><pub>American Diabetes Association</pub><doi>10.2337/db18-612-P</doi></addata></record>
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subjects Adults
Fasting
Fatty liver
Fibrosis
Glucose
Homeostasis
Insulin
Insulin resistance
Liver diseases
Oils & fats
Risk factors
Triglycerides
Ultrasound
title Relationship between the Triglyceride Glucose Index and the Presence and Fibrosis of Nonalcoholic Fatty Liver Disease in Korean Adults
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