Relationship between Nitrated High-Density Lipoproteins and Vascular Function in African-American Diabetic Patients
Previous studies have shown that HDL isolated from human atherosclerotic lesions and the blood of patients with established coronary artery disease contains elevated levels of nitrated apolipoprotein AI (NT-apoAI). The significance of NT-apoAI in the pathogenesis of vascular diabetic complications i...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2018-07, Vol.67 (Supplement_1) |
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| creator | ADEDAYO, AJIBOLA M. ELUWOLE, AYOBAMI TEDLA, FASIKA KREMER, ARYE MASTROGIOVANNI, NICOLE ROSENBERG, CARL DREIZEN, PAUL LAROSA, JOHN SALCICCIOLI, LOUIS BOUTJDIR, MOHAMED BANERJI, MARY ANN BROWN, CLINTON SALIFU, MORO LAZAR, JASON BAKILLAH, AHMED |
| description | Previous studies have shown that HDL isolated from human atherosclerotic lesions and the blood of patients with established coronary artery disease contains elevated levels of nitrated apolipoprotein AI (NT-apoAI). The significance of NT-apoAI in the pathogenesis of vascular diabetic complications is not well understood. We aimed to evaluate the relationship between plasma NT-apoAI and vascular function in African-Americans diabetic patients. 125 patients with type 2 diabetes were enrolled over a 6 months period. Levels of plasma NT-apoAI was quantified by enzyme-linked immunosorbent assays (ELISA). Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound image analysis. Patients population was divided in two groups (well-controlled: HbA1c ≤7.0%, N=54; poorly-controlled: HbA1c >7.0%, N=71). Mean age 60±8 years; 64% female; 80% had hypertension; 90% had dyslipidemia and 15% had CKD. Mean HbA1c levels were 8.1±2.2% and duration of diabetes was 10.29±3.79 years. NT-apoAI was negatively correlated with levels of apoAI and VRI in well-controlled patients but not in poorly-controlled patients (r= -0.298, p=0.025 and r= -0.265, p=0.042; respectively). Multi-regression analysis revealed that NT-apoAI was independently associated with VRI, but neither with PWV nor CIMT, after adjustment for independent variables such as age, gender, weight, hypertension, stroke, smoking, duration of diabetes, dyslipidemia, total cholesterol, HDLc, triglycerides, and LDLc (β= 0.001, p= 0.025; r2= 0.325 for the model). NT-apoAI, independently of other clinical variables, can predict microvascular dysfunction particularly in well-controlled diabetic patients. NT-apoAI could be used as marker to identify diabetic patients at risk of developing early vascular complications. |
| doi_str_mv | 10.2337/db18-611-P |
| format | Article |
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The significance of NT-apoAI in the pathogenesis of vascular diabetic complications is not well understood. We aimed to evaluate the relationship between plasma NT-apoAI and vascular function in African-Americans diabetic patients. 125 patients with type 2 diabetes were enrolled over a 6 months period. Levels of plasma NT-apoAI was quantified by enzyme-linked immunosorbent assays (ELISA). Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound image analysis. Patients population was divided in two groups (well-controlled: HbA1c ≤7.0%, N=54; poorly-controlled: HbA1c >7.0%, N=71). Mean age 60±8 years; 64% female; 80% had hypertension; 90% had dyslipidemia and 15% had CKD. Mean HbA1c levels were 8.1±2.2% and duration of diabetes was 10.29±3.79 years. NT-apoAI was negatively correlated with levels of apoAI and VRI in well-controlled patients but not in poorly-controlled patients (r= -0.298, p=0.025 and r= -0.265, p=0.042; respectively). Multi-regression analysis revealed that NT-apoAI was independently associated with VRI, but neither with PWV nor CIMT, after adjustment for independent variables such as age, gender, weight, hypertension, stroke, smoking, duration of diabetes, dyslipidemia, total cholesterol, HDLc, triglycerides, and LDLc (β= 0.001, p= 0.025; r2= 0.325 for the model). NT-apoAI, independently of other clinical variables, can predict microvascular dysfunction particularly in well-controlled diabetic patients. NT-apoAI could be used as marker to identify diabetic patients at risk of developing early vascular complications.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db18-611-P</identifier><language>eng</language><publisher>New York: American Diabetes Association</publisher><subject>African Americans ; Apolipoproteins ; Arteriosclerosis ; Cardiovascular disease ; Cholesterol ; Coronary artery ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Dyslipidemia ; Enzyme-linked immunosorbent assay ; Femur ; Heart diseases ; High density lipoprotein ; Hypertension ; Image processing ; Lipoproteins ; Microvasculature ; Pathogenesis ; Smoking ; Triglycerides ; Ultrasound ; Vein & artery diseases</subject><ispartof>Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)</ispartof><rights>Copyright American Diabetes Association Jul 1, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>ADEDAYO, AJIBOLA M.</creatorcontrib><creatorcontrib>ELUWOLE, AYOBAMI</creatorcontrib><creatorcontrib>TEDLA, FASIKA</creatorcontrib><creatorcontrib>KREMER, ARYE</creatorcontrib><creatorcontrib>MASTROGIOVANNI, NICOLE</creatorcontrib><creatorcontrib>ROSENBERG, CARL</creatorcontrib><creatorcontrib>DREIZEN, PAUL</creatorcontrib><creatorcontrib>LAROSA, JOHN</creatorcontrib><creatorcontrib>SALCICCIOLI, LOUIS</creatorcontrib><creatorcontrib>BOUTJDIR, MOHAMED</creatorcontrib><creatorcontrib>BANERJI, MARY ANN</creatorcontrib><creatorcontrib>BROWN, CLINTON</creatorcontrib><creatorcontrib>SALIFU, MORO</creatorcontrib><creatorcontrib>LAZAR, JASON</creatorcontrib><creatorcontrib>BAKILLAH, AHMED</creatorcontrib><title>Relationship between Nitrated High-Density Lipoproteins and Vascular Function in African-American Diabetic Patients</title><title>Diabetes (New York, N.Y.)</title><description>Previous studies have shown that HDL isolated from human atherosclerotic lesions and the blood of patients with established coronary artery disease contains elevated levels of nitrated apolipoprotein AI (NT-apoAI). The significance of NT-apoAI in the pathogenesis of vascular diabetic complications is not well understood. We aimed to evaluate the relationship between plasma NT-apoAI and vascular function in African-Americans diabetic patients. 125 patients with type 2 diabetes were enrolled over a 6 months period. Levels of plasma NT-apoAI was quantified by enzyme-linked immunosorbent assays (ELISA). Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound image analysis. Patients population was divided in two groups (well-controlled: HbA1c ≤7.0%, N=54; poorly-controlled: HbA1c >7.0%, N=71). Mean age 60±8 years; 64% female; 80% had hypertension; 90% had dyslipidemia and 15% had CKD. Mean HbA1c levels were 8.1±2.2% and duration of diabetes was 10.29±3.79 years. NT-apoAI was negatively correlated with levels of apoAI and VRI in well-controlled patients but not in poorly-controlled patients (r= -0.298, p=0.025 and r= -0.265, p=0.042; respectively). Multi-regression analysis revealed that NT-apoAI was independently associated with VRI, but neither with PWV nor CIMT, after adjustment for independent variables such as age, gender, weight, hypertension, stroke, smoking, duration of diabetes, dyslipidemia, total cholesterol, HDLc, triglycerides, and LDLc (β= 0.001, p= 0.025; r2= 0.325 for the model). NT-apoAI, independently of other clinical variables, can predict microvascular dysfunction particularly in well-controlled diabetic patients. NT-apoAI could be used as marker to identify diabetic patients at risk of developing early vascular complications.</description><subject>African Americans</subject><subject>Apolipoproteins</subject><subject>Arteriosclerosis</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Coronary artery</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Dyslipidemia</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Femur</subject><subject>Heart diseases</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Image processing</subject><subject>Lipoproteins</subject><subject>Microvasculature</subject><subject>Pathogenesis</subject><subject>Smoking</subject><subject>Triglycerides</subject><subject>Ultrasound</subject><subject>Vein & artery diseases</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNotkE9LAzEQxYMoWKsXP0HAmxDNH5rdHEtrrVC0SBFvYTabtSnb7JpkkX57UytzmBl4_N7jIXTL6AMXonisK1YSyRhZn6ERU0IRwYvPczSilHHCClVcoqsYd5RSmWeE4rttIbnOx63rcWXTj7Uev7oUINkaL93Xlsytjy4d8Mr1XR-6ZJ2PGHyNPyCaoYWAF4M3Rwh2Hk-b4Ax4Mt3bvwPPHWSuM3idjaxP8RpdNNBGe_O_x2izeNrMlmT19vwym66IkYIR0YiqEiWAtLYBOYH8qIlgFTWSmhpkI2nJS1krQxXnghkrZCGbsgZBa27EGN2dsDnz92Bj0rtuCD47ak6VUiUVBcuq-5PKhC7GYBvdB7eHcNCM6mOn-tipzp3qtfgFGlprTQ</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>ADEDAYO, AJIBOLA M.</creator><creator>ELUWOLE, AYOBAMI</creator><creator>TEDLA, FASIKA</creator><creator>KREMER, ARYE</creator><creator>MASTROGIOVANNI, NICOLE</creator><creator>ROSENBERG, CARL</creator><creator>DREIZEN, PAUL</creator><creator>LAROSA, JOHN</creator><creator>SALCICCIOLI, LOUIS</creator><creator>BOUTJDIR, MOHAMED</creator><creator>BANERJI, MARY ANN</creator><creator>BROWN, CLINTON</creator><creator>SALIFU, MORO</creator><creator>LAZAR, JASON</creator><creator>BAKILLAH, AHMED</creator><general>American Diabetes Association</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20180701</creationdate><title>Relationship between Nitrated High-Density Lipoproteins and Vascular Function in African-American Diabetic Patients</title><author>ADEDAYO, AJIBOLA M. ; ELUWOLE, AYOBAMI ; TEDLA, FASIKA ; KREMER, ARYE ; MASTROGIOVANNI, NICOLE ; ROSENBERG, CARL ; DREIZEN, PAUL ; LAROSA, JOHN ; SALCICCIOLI, LOUIS ; BOUTJDIR, MOHAMED ; BANERJI, MARY ANN ; BROWN, CLINTON ; SALIFU, MORO ; LAZAR, JASON ; BAKILLAH, AHMED</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c631-3f3bb38aa6eefa65ab389531b0c60cda6f608286d9c092231ce3676f8da30d2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>African Americans</topic><topic>Apolipoproteins</topic><topic>Arteriosclerosis</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Coronary artery</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Dyslipidemia</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Femur</topic><topic>Heart diseases</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Image processing</topic><topic>Lipoproteins</topic><topic>Microvasculature</topic><topic>Pathogenesis</topic><topic>Smoking</topic><topic>Triglycerides</topic><topic>Ultrasound</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ADEDAYO, AJIBOLA M.</creatorcontrib><creatorcontrib>ELUWOLE, AYOBAMI</creatorcontrib><creatorcontrib>TEDLA, FASIKA</creatorcontrib><creatorcontrib>KREMER, ARYE</creatorcontrib><creatorcontrib>MASTROGIOVANNI, NICOLE</creatorcontrib><creatorcontrib>ROSENBERG, CARL</creatorcontrib><creatorcontrib>DREIZEN, PAUL</creatorcontrib><creatorcontrib>LAROSA, JOHN</creatorcontrib><creatorcontrib>SALCICCIOLI, LOUIS</creatorcontrib><creatorcontrib>BOUTJDIR, MOHAMED</creatorcontrib><creatorcontrib>BANERJI, MARY ANN</creatorcontrib><creatorcontrib>BROWN, CLINTON</creatorcontrib><creatorcontrib>SALIFU, MORO</creatorcontrib><creatorcontrib>LAZAR, JASON</creatorcontrib><creatorcontrib>BAKILLAH, AHMED</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ADEDAYO, AJIBOLA M.</au><au>ELUWOLE, AYOBAMI</au><au>TEDLA, FASIKA</au><au>KREMER, ARYE</au><au>MASTROGIOVANNI, NICOLE</au><au>ROSENBERG, CARL</au><au>DREIZEN, PAUL</au><au>LAROSA, JOHN</au><au>SALCICCIOLI, LOUIS</au><au>BOUTJDIR, MOHAMED</au><au>BANERJI, MARY ANN</au><au>BROWN, CLINTON</au><au>SALIFU, MORO</au><au>LAZAR, JASON</au><au>BAKILLAH, AHMED</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Nitrated High-Density Lipoproteins and Vascular Function in African-American Diabetic Patients</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><date>2018-07-01</date><risdate>2018</risdate><volume>67</volume><issue>Supplement_1</issue><issn>0012-1797</issn><eissn>1939-327X</eissn><abstract>Previous studies have shown that HDL isolated from human atherosclerotic lesions and the blood of patients with established coronary artery disease contains elevated levels of nitrated apolipoprotein AI (NT-apoAI). The significance of NT-apoAI in the pathogenesis of vascular diabetic complications is not well understood. We aimed to evaluate the relationship between plasma NT-apoAI and vascular function in African-Americans diabetic patients. 125 patients with type 2 diabetes were enrolled over a 6 months period. Levels of plasma NT-apoAI was quantified by enzyme-linked immunosorbent assays (ELISA). Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound image analysis. Patients population was divided in two groups (well-controlled: HbA1c ≤7.0%, N=54; poorly-controlled: HbA1c >7.0%, N=71). Mean age 60±8 years; 64% female; 80% had hypertension; 90% had dyslipidemia and 15% had CKD. Mean HbA1c levels were 8.1±2.2% and duration of diabetes was 10.29±3.79 years. NT-apoAI was negatively correlated with levels of apoAI and VRI in well-controlled patients but not in poorly-controlled patients (r= -0.298, p=0.025 and r= -0.265, p=0.042; respectively). Multi-regression analysis revealed that NT-apoAI was independently associated with VRI, but neither with PWV nor CIMT, after adjustment for independent variables such as age, gender, weight, hypertension, stroke, smoking, duration of diabetes, dyslipidemia, total cholesterol, HDLc, triglycerides, and LDLc (β= 0.001, p= 0.025; r2= 0.325 for the model). NT-apoAI, independently of other clinical variables, can predict microvascular dysfunction particularly in well-controlled diabetic patients. NT-apoAI could be used as marker to identify diabetic patients at risk of developing early vascular complications.</abstract><cop>New York</cop><pub>American Diabetes Association</pub><doi>10.2337/db18-611-P</doi></addata></record> |
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| subjects | African Americans Apolipoproteins Arteriosclerosis Cardiovascular disease Cholesterol Coronary artery Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dyslipidemia Enzyme-linked immunosorbent assay Femur Heart diseases High density lipoprotein Hypertension Image processing Lipoproteins Microvasculature Pathogenesis Smoking Triglycerides Ultrasound Vein & artery diseases |
| title | Relationship between Nitrated High-Density Lipoproteins and Vascular Function in African-American Diabetic Patients |
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