Epothilone D accelerates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Aims Degeneration of the distal neuromuscular circuitry is a hallmark pathology of Amyotrophic Lateral Sclerosis (ALS). The potential for microtubule dysfunction to be a critical pathophysiological mechanism in the destruction of this circuitry is increasingly being appreciated. Stabilization of mic...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2018-10, Vol.44 (6), p.590-605
Hauptverfasser:	Clark, J. A., Blizzard, C. A., Breslin, M. C., Yeaman, E. J., Lee, K. M., Chuckowree, J. A., Dickson, T. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis Cell body Disease Epothilone D Gliosis Microtubule stabilisation Microtubules Motor behaviour Neurodegeneration Neurodegenerative diseases Neuromuscular junctions Neurotoxicity Phenotypes Synapses Toxicity
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