The pediatric acenocoumarol dosing algorithm: the Children Anticoagulation and Pharmacogenetics Study

Essentials A pediatric pharmacogenetic dosing algorithm for acenocoumarol has not yet been developed. We conducted a multicenter retrospective follow‐up study in children in the Netherlands. Body surface area and indication explained 45.0% of the variability in dose requirement. Adding the genotypes...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2018-09, Vol.16 (9), p.1732-1742
Hauptverfasser:	Maagdenberg, H., Bierings, M. B., Ommen, C. H., Meer, F. J. M., Appel, I. M., Tamminga, R. Y. J., Cessie, S., Swen, J. J., Straaten, T., Boer, A., Maitland‐van der Zee, A. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	acenocoumarol Acenocoumarol - administration & dosage Acenocoumarol - analysis Acenocoumarol - pharmacokinetics Adolescent Age Factors Algorithms Antagonists Anticoagulants - administration & dosage Anticoagulants - analysis Anticoagulants - pharmacokinetics Biological Variation, Individual Biotransformation - genetics Body Surface Area Child Child, Preschool Children coumarins Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Dose-Response Relationship, Drug Female Follow-Up Studies Genetic Association Studies Genetic factors Genotypes Genotyping Humans Infant Male Models, Biological Pediatrics Pharmacogenetics Polymorphism, Single Nucleotide Practice Guidelines as Topic Reductase Retrospective Studies Saliva Saliva - chemistry Thrombophilia - drug therapy Vitamin K Vitamin K - antagonists & inhibitors Warfarin
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