Negative predictors of clinical response to amitriptyline in Japanese patients with migraine
Background Migraine is the most common neurological disease. Recently, there is a wide variety of prophylactic drugs, but their effects differ among individuals. Aim To investigate clinical factors affecting the response to amitriptyline therapy and establish a scoring system for predicting the nega...
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| Veröffentlicht in: | Neurology and clinical neuroscience 2018-09, Vol.6 (5), p.125-130 |
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| creator | Naito, Yuika Ishii, Masakazu Ishibashi, Masaaki Kasai, Hideyo Katoh, Hirotaka |
| description | Background
Migraine is the most common neurological disease. Recently, there is a wide variety of prophylactic drugs, but their effects differ among individuals.
Aim
To investigate clinical factors affecting the response to amitriptyline therapy and establish a scoring system for predicting the negative response to prophylactic therapy.
Methods
We examined clinical factors from medical records of 29 consistent responders (CRs) and 21 inconsistent responders (IRs) to amitriptyline.
Results
Multivariate analysis revealed that a past history of medication overuse headache (MOH) and allodynia from associated symptoms were significant factors that independently contributed to a negative response. Odds ratio of MOH was 4.489 (no vs yes; 95% CI = 1.109–14.224), and odds ratio of allodynia was 4.489 (yes vs no; 95% CI = 1.109–14.224). A predictive index (PI) of the negative response to amitriptyline in patients with migraine was calculated using the regression coefficients of these two factors as integers, and the index was significantly higher for IRs than CRs (1.33 ± 0.58 vs 0.76 ± 0.69, mean ± SD, P = 0.003)
Conclusion
The obtained PI may represent an appropriate scoring system for negative responses in patients using amitriptyline. |
| doi_str_mv | 10.1111/ncn3.12209 |
| format | Article |
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Migraine is the most common neurological disease. Recently, there is a wide variety of prophylactic drugs, but their effects differ among individuals.
Aim
To investigate clinical factors affecting the response to amitriptyline therapy and establish a scoring system for predicting the negative response to prophylactic therapy.
Methods
We examined clinical factors from medical records of 29 consistent responders (CRs) and 21 inconsistent responders (IRs) to amitriptyline.
Results
Multivariate analysis revealed that a past history of medication overuse headache (MOH) and allodynia from associated symptoms were significant factors that independently contributed to a negative response. Odds ratio of MOH was 4.489 (no vs yes; 95% CI = 1.109–14.224), and odds ratio of allodynia was 4.489 (yes vs no; 95% CI = 1.109–14.224). A predictive index (PI) of the negative response to amitriptyline in patients with migraine was calculated using the regression coefficients of these two factors as integers, and the index was significantly higher for IRs than CRs (1.33 ± 0.58 vs 0.76 ± 0.69, mean ± SD, P = 0.003)
Conclusion
The obtained PI may represent an appropriate scoring system for negative responses in patients using amitriptyline.</description><identifier>ISSN: 2049-4173</identifier><identifier>EISSN: 2049-4173</identifier><identifier>DOI: 10.1111/ncn3.12209</identifier><language>eng</language><publisher>Tokyo: Wiley Subscription Services, Inc</publisher><subject>allodynia ; Amitriptyline ; Headache ; Medical records ; medication overuse headache ; Migraine ; Multivariate analysis ; Neurological diseases ; Pain perception ; Patients ; tension‐type headache</subject><ispartof>Neurology and clinical neuroscience, 2018-09, Vol.6 (5), p.125-130</ispartof><rights>2018 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd</rights><rights>Copyright © 2018 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2739-7ff7378341142e50bc11524190bf15819bbe8f1081e4b37380ff49e9672c1c1e3</cites><orcidid>0000-0003-4653-1029</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fncn3.12209$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fncn3.12209$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Naito, Yuika</creatorcontrib><creatorcontrib>Ishii, Masakazu</creatorcontrib><creatorcontrib>Ishibashi, Masaaki</creatorcontrib><creatorcontrib>Kasai, Hideyo</creatorcontrib><creatorcontrib>Katoh, Hirotaka</creatorcontrib><title>Negative predictors of clinical response to amitriptyline in Japanese patients with migraine</title><title>Neurology and clinical neuroscience</title><description>Background
Migraine is the most common neurological disease. Recently, there is a wide variety of prophylactic drugs, but their effects differ among individuals.
Aim
To investigate clinical factors affecting the response to amitriptyline therapy and establish a scoring system for predicting the negative response to prophylactic therapy.
Methods
We examined clinical factors from medical records of 29 consistent responders (CRs) and 21 inconsistent responders (IRs) to amitriptyline.
Results
Multivariate analysis revealed that a past history of medication overuse headache (MOH) and allodynia from associated symptoms were significant factors that independently contributed to a negative response. Odds ratio of MOH was 4.489 (no vs yes; 95% CI = 1.109–14.224), and odds ratio of allodynia was 4.489 (yes vs no; 95% CI = 1.109–14.224). A predictive index (PI) of the negative response to amitriptyline in patients with migraine was calculated using the regression coefficients of these two factors as integers, and the index was significantly higher for IRs than CRs (1.33 ± 0.58 vs 0.76 ± 0.69, mean ± SD, P = 0.003)
Conclusion
The obtained PI may represent an appropriate scoring system for negative responses in patients using amitriptyline.</description><subject>allodynia</subject><subject>Amitriptyline</subject><subject>Headache</subject><subject>Medical records</subject><subject>medication overuse headache</subject><subject>Migraine</subject><subject>Multivariate analysis</subject><subject>Neurological diseases</subject><subject>Pain perception</subject><subject>Patients</subject><subject>tension‐type headache</subject><issn>2049-4173</issn><issn>2049-4173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LAzEQxYMoWLQXP0HAm9CaSXa7yVGKfyn1ojch7MZJTdlm1yS19Nubuh48-S4z8H7zBh4hF8CmkHXtjRdT4JypIzLirFCTAipx_Gc_JeMY1yxLKQFKjsjbEld1cl9I-4DvzqQuRNpZalrnnalbGjD2nY9IU0frjUvB9WmfTaTO06e6rz1ms88Z6FOkO5c-6MatQp2Rc3Ji6zbi-Heekde725f5w2TxfP84v1lMDK-EmlTWVqKSogAoOJasMQAlL0CxxkIpQTUNSgtMAhaNqIRk1hYK1aziBgygOCOXQ24fus8txqTX3Tb4_FLnMqSclVLyTF0NlAldjAGt7oPb1GGvgelDgfpQoP4pMMMwwDvX4v4fUi_nSzHcfAMzkXIU</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Naito, Yuika</creator><creator>Ishii, Masakazu</creator><creator>Ishibashi, Masaaki</creator><creator>Kasai, Hideyo</creator><creator>Katoh, Hirotaka</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-4653-1029</orcidid></search><sort><creationdate>201809</creationdate><title>Negative predictors of clinical response to amitriptyline in Japanese patients with migraine</title><author>Naito, Yuika ; Ishii, Masakazu ; Ishibashi, Masaaki ; Kasai, Hideyo ; Katoh, Hirotaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2739-7ff7378341142e50bc11524190bf15819bbe8f1081e4b37380ff49e9672c1c1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>allodynia</topic><topic>Amitriptyline</topic><topic>Headache</topic><topic>Medical records</topic><topic>medication overuse headache</topic><topic>Migraine</topic><topic>Multivariate analysis</topic><topic>Neurological diseases</topic><topic>Pain perception</topic><topic>Patients</topic><topic>tension‐type headache</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naito, Yuika</creatorcontrib><creatorcontrib>Ishii, Masakazu</creatorcontrib><creatorcontrib>Ishibashi, Masaaki</creatorcontrib><creatorcontrib>Kasai, Hideyo</creatorcontrib><creatorcontrib>Katoh, Hirotaka</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Neurology and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naito, Yuika</au><au>Ishii, Masakazu</au><au>Ishibashi, Masaaki</au><au>Kasai, Hideyo</au><au>Katoh, Hirotaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Negative predictors of clinical response to amitriptyline in Japanese patients with migraine</atitle><jtitle>Neurology and clinical neuroscience</jtitle><date>2018-09</date><risdate>2018</risdate><volume>6</volume><issue>5</issue><spage>125</spage><epage>130</epage><pages>125-130</pages><issn>2049-4173</issn><eissn>2049-4173</eissn><abstract>Background
Migraine is the most common neurological disease. Recently, there is a wide variety of prophylactic drugs, but their effects differ among individuals.
Aim
To investigate clinical factors affecting the response to amitriptyline therapy and establish a scoring system for predicting the negative response to prophylactic therapy.
Methods
We examined clinical factors from medical records of 29 consistent responders (CRs) and 21 inconsistent responders (IRs) to amitriptyline.
Results
Multivariate analysis revealed that a past history of medication overuse headache (MOH) and allodynia from associated symptoms were significant factors that independently contributed to a negative response. Odds ratio of MOH was 4.489 (no vs yes; 95% CI = 1.109–14.224), and odds ratio of allodynia was 4.489 (yes vs no; 95% CI = 1.109–14.224). A predictive index (PI) of the negative response to amitriptyline in patients with migraine was calculated using the regression coefficients of these two factors as integers, and the index was significantly higher for IRs than CRs (1.33 ± 0.58 vs 0.76 ± 0.69, mean ± SD, P = 0.003)
Conclusion
The obtained PI may represent an appropriate scoring system for negative responses in patients using amitriptyline.</abstract><cop>Tokyo</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/ncn3.12209</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4653-1029</orcidid></addata></record> |
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| ispartof | Neurology and clinical neuroscience, 2018-09, Vol.6 (5), p.125-130 |
| issn | 2049-4173 2049-4173 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | allodynia Amitriptyline Headache Medical records medication overuse headache Migraine Multivariate analysis Neurological diseases Pain perception Patients tension‐type headache |
| title | Negative predictors of clinical response to amitriptyline in Japanese patients with migraine |
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