Sandwich-type microRNA biosensor based on magnesium oxide nanoflower and graphene oxide–gold nanoparticles hybrids coupling with enzyme signal amplification

•Facile approach was used for the synthesis of MgO nanoflowers.•MgO nanoflowers/AuNPs were used as sensing platform and GO–AuNPs hybrids as signal carriers.•Electrochemical–chemical–chemical redox cycling was used as a sensitive detection system.•A sandwich-type assay showed a low detection limit of...

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Veröffentlicht in:	Sensors and actuators. B, Chemical Chemical, 2017-05, Vol.243, p.403-411
Hauptverfasser:	Shuai, Hong-Lei, Huang, Ke-Jing, Zhang, Wen-Jing, Cao, Xiaoyu, Jia, Meng-Pei
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Biosensors Biotin Coupling Deoxyribonucleic acid DNA Electrodes Enzyme signal amplification Gold Graphene Graphene oxide–gold nanoparticles hybrids Magnesium oxide Magnesium oxide nanoflowers MiRNA-21 Nanoparticles Organic chemistry Ribonucleic acid RNA Sandwich-type biosensor Self-assembly Sensitivity enhancement Substrates Superconductors (materials)
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