Post-mortem in situ stability of serum markers of cerebral damage and acute phase response
The aim of the given study was to test the in situ stability of biochemical markers of cerebral damage and acute phase response in the early post-mortem interval to assess their usability for forensic pathology. A monocentric, prospective study investigated post-mortem femoral venous blood samples a...
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| Veröffentlicht in: | International journal of legal medicine 2019-05, Vol.133 (3), p.871-881 |
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| creator | Ondruschka, Benjamin Woydt, Lina Bernhard, Michael Franke, Heike Kirsten, Holger Löffler, Sabine Pohlers, Dirk Hammer, Niels Dreßler, Jan |
| description | The aim of the given study was to test the in situ stability of biochemical markers of cerebral damage and acute phase response in the early post-mortem interval to assess their usability for forensic pathology. A monocentric, prospective study investigated post-mortem femoral venous blood samples at four time points obtained within 48 h post-mortem starting at the death of 20 deceased, using commercial immunoassays for the ten parameters: S100 calcium-binding protein B (S100B), glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), C-reactive protein (CRP), procalcitonin (PCT), ferritin, soluble tumor necrosis factor receptor type 1 (sTNFR1), and lactate dehydrogenase (LDH). Significant changes in serum levels were observed only later than 2 h after death for all markers. Inter-laboratory comparability was high, and intra-assay precision was sufficient for most markers. Most of the biomarker levels depended on the severity of hemolysis and lipemia but were robust against freeze-thaw cycles. Serum levels increased with longer post-mortem intervals for S100B, NSE, ferritin, sTNFR1, and LDH (for all
p
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| doi_str_mv | 10.1007/s00414-018-1925-2 |
| format | Article |
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p
< 0.001) but decreased over this period for CRP (
p
= 0.089) and PCT (
p
< 0.001). Largely unchanged median values were found for GFAP (
p
= 0.139), BDNF (
p
= 0.106), and IL-6 (
p
= 0.094). Serum levels of CRP (
p
= 0.059) and LDH (
p
= 0.109) did not differ significantly between the final ante-mortem (resuscitation) and the first post-mortem sample (moment of death). Collecting the post-mortem blood sample as soon as possible will reduce the influence of post-mortem blood changes. Serum GFAP for detection of cerebral damage as well as serum IL-6 and CRP as proof of acute phase response seemed to be preferable due to their in situ stability in the first 2 days after death.</description><identifier>ISSN: 0937-9827</identifier><identifier>EISSN: 1437-1596</identifier><identifier>DOI: 10.1007/s00414-018-1925-2</identifier><identifier>PMID: 30167776</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acute-Phase Reaction ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Biomarkers - blood ; Blood ; Brain ; Brain Injuries - blood ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; C-Reactive Protein - analysis ; Damage assessment ; Damage detection ; Death ; Female ; Ferritin ; Ferritins - blood ; Forensic Medicine ; Forensic pathology ; Freeze thaw cycles ; Glial Fibrillary Acidic Protein - blood ; Humans ; Immunoassay ; Interleukin-6 - blood ; Interleukins ; L-Lactate Dehydrogenase - blood ; Lactate dehydrogenase ; Male ; Medical Law ; Medicine & Public Health ; Middle Aged ; Original Article ; Phosphopyruvate Hydratase - blood ; Postmortem Changes ; Procalcitonin - blood ; Prospective Studies ; Proteins ; Receptors, Tumor Necrosis Factor, Type I - blood ; Resuscitation ; S100 Calcium Binding Protein beta Subunit - blood ; Stability</subject><ispartof>International journal of legal medicine, 2019-05, Vol.133 (3), p.871-881</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>International Journal of Legal Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b9cec6fb2d673a3f4e496a2a2fecc13ca98fa5defac4eda04604a3880a28a6fc3</citedby><cites>FETCH-LOGICAL-c372t-b9cec6fb2d673a3f4e496a2a2fecc13ca98fa5defac4eda04604a3880a28a6fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00414-018-1925-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00414-018-1925-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30167776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ondruschka, Benjamin</creatorcontrib><creatorcontrib>Woydt, Lina</creatorcontrib><creatorcontrib>Bernhard, Michael</creatorcontrib><creatorcontrib>Franke, Heike</creatorcontrib><creatorcontrib>Kirsten, Holger</creatorcontrib><creatorcontrib>Löffler, Sabine</creatorcontrib><creatorcontrib>Pohlers, Dirk</creatorcontrib><creatorcontrib>Hammer, Niels</creatorcontrib><creatorcontrib>Dreßler, Jan</creatorcontrib><title>Post-mortem in situ stability of serum markers of cerebral damage and acute phase response</title><title>International journal of legal medicine</title><addtitle>Int J Legal Med</addtitle><addtitle>Int J Legal Med</addtitle><description>The aim of the given study was to test the in situ stability of biochemical markers of cerebral damage and acute phase response in the early post-mortem interval to assess their usability for forensic pathology. A monocentric, prospective study investigated post-mortem femoral venous blood samples at four time points obtained within 48 h post-mortem starting at the death of 20 deceased, using commercial immunoassays for the ten parameters: S100 calcium-binding protein B (S100B), glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), C-reactive protein (CRP), procalcitonin (PCT), ferritin, soluble tumor necrosis factor receptor type 1 (sTNFR1), and lactate dehydrogenase (LDH). Significant changes in serum levels were observed only later than 2 h after death for all markers. Inter-laboratory comparability was high, and intra-assay precision was sufficient for most markers. Most of the biomarker levels depended on the severity of hemolysis and lipemia but were robust against freeze-thaw cycles. Serum levels increased with longer post-mortem intervals for S100B, NSE, ferritin, sTNFR1, and LDH (for all
p
< 0.001) but decreased over this period for CRP (
p
= 0.089) and PCT (
p
< 0.001). Largely unchanged median values were found for GFAP (
p
= 0.139), BDNF (
p
= 0.106), and IL-6 (
p
= 0.094). Serum levels of CRP (
p
= 0.059) and LDH (
p
= 0.109) did not differ significantly between the final ante-mortem (resuscitation) and the first post-mortem sample (moment of death). Collecting the post-mortem blood sample as soon as possible will reduce the influence of post-mortem blood changes. Serum GFAP for detection of cerebral damage as well as serum IL-6 and CRP as proof of acute phase response seemed to be preferable due to their in situ stability in the first 2 days after death.</description><subject>Acute-Phase Reaction</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Brain</subject><subject>Brain Injuries - blood</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Damage assessment</subject><subject>Damage detection</subject><subject>Death</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferritins - blood</subject><subject>Forensic Medicine</subject><subject>Forensic pathology</subject><subject>Freeze thaw cycles</subject><subject>Glial Fibrillary Acidic Protein - blood</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Interleukin-6 - blood</subject><subject>Interleukins</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Lactate dehydrogenase</subject><subject>Male</subject><subject>Medical Law</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Phosphopyruvate Hydratase - blood</subject><subject>Postmortem Changes</subject><subject>Procalcitonin - blood</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Receptors, Tumor Necrosis Factor, Type I - blood</subject><subject>Resuscitation</subject><subject>S100 Calcium Binding Protein beta Subunit - blood</subject><subject>Stability</subject><issn>0937-9827</issn><issn>1437-1596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kD9PwzAQxS0EoqXwAViQJeaA7Th2MiLEP6kSDLCwWBfnXFKapNjO0G9PohSYmO509-493Y-Qc86uOGP6OjAmuUwYzxNeiCwRB2TOZaoTnhXqkMxZMfRFLvSMnISwZoxrpbNjMksZV1prNSfvL12ISdP5iA2tWxrq2NMQoaw3ddzRztGAvm9oA_4TfRgHFj2WHja0ggZWSKGtKNg-It1-QEDqMWy7NuApOXKwCXi2rwvydn_3evuYLJ8fnm5vlolNtYhJWVi0ypWiUjqF1EmUhQIBwqG1PLVQ5A6yCh1YiRUwqZiENM8ZiByUs-mCXE6-W9999RiiWXe9b4dII1ihhZZSiEHFJ5X1XQgendn6evhqZzgzI00z0TQDTTPSNOPNxd65Lxusfi9-8A0CMQnCsGpX6P-i_3f9Bk7_gTo</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Ondruschka, Benjamin</creator><creator>Woydt, Lina</creator><creator>Bernhard, Michael</creator><creator>Franke, Heike</creator><creator>Kirsten, Holger</creator><creator>Löffler, Sabine</creator><creator>Pohlers, Dirk</creator><creator>Hammer, Niels</creator><creator>Dreßler, Jan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AM</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BGRYB</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9.</scope><scope>L6V</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>Q9U</scope></search><sort><creationdate>20190501</creationdate><title>Post-mortem in situ stability of serum markers of cerebral damage and acute phase response</title><author>Ondruschka, Benjamin ; Woydt, Lina ; Bernhard, Michael ; Franke, Heike ; Kirsten, Holger ; Löffler, Sabine ; Pohlers, Dirk ; Hammer, Niels ; Dreßler, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-b9cec6fb2d673a3f4e496a2a2fecc13ca98fa5defac4eda04604a3880a28a6fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute-Phase Reaction</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Brain</topic><topic>Brain Injuries - blood</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Damage assessment</topic><topic>Damage detection</topic><topic>Death</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins - blood</topic><topic>Forensic Medicine</topic><topic>Forensic pathology</topic><topic>Freeze thaw cycles</topic><topic>Glial Fibrillary Acidic Protein - blood</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Interleukin-6 - blood</topic><topic>Interleukins</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Lactate dehydrogenase</topic><topic>Male</topic><topic>Medical Law</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Phosphopyruvate Hydratase - blood</topic><topic>Postmortem Changes</topic><topic>Procalcitonin - blood</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Receptors, Tumor Necrosis Factor, Type I - blood</topic><topic>Resuscitation</topic><topic>S100 Calcium Binding Protein beta Subunit - blood</topic><topic>Stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ondruschka, Benjamin</creatorcontrib><creatorcontrib>Woydt, Lina</creatorcontrib><creatorcontrib>Bernhard, Michael</creatorcontrib><creatorcontrib>Franke, Heike</creatorcontrib><creatorcontrib>Kirsten, Holger</creatorcontrib><creatorcontrib>Löffler, Sabine</creatorcontrib><creatorcontrib>Pohlers, Dirk</creatorcontrib><creatorcontrib>Hammer, Niels</creatorcontrib><creatorcontrib>Dreßler, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Criminology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Criminal Justice</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>ProQuest Central Basic</collection><jtitle>International journal of legal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ondruschka, Benjamin</au><au>Woydt, Lina</au><au>Bernhard, Michael</au><au>Franke, Heike</au><au>Kirsten, Holger</au><au>Löffler, Sabine</au><au>Pohlers, Dirk</au><au>Hammer, Niels</au><au>Dreßler, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-mortem in situ stability of serum markers of cerebral damage and acute phase response</atitle><jtitle>International journal of legal medicine</jtitle><stitle>Int J Legal Med</stitle><addtitle>Int J Legal Med</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>133</volume><issue>3</issue><spage>871</spage><epage>881</epage><pages>871-881</pages><issn>0937-9827</issn><eissn>1437-1596</eissn><abstract>The aim of the given study was to test the in situ stability of biochemical markers of cerebral damage and acute phase response in the early post-mortem interval to assess their usability for forensic pathology. A monocentric, prospective study investigated post-mortem femoral venous blood samples at four time points obtained within 48 h post-mortem starting at the death of 20 deceased, using commercial immunoassays for the ten parameters: S100 calcium-binding protein B (S100B), glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), C-reactive protein (CRP), procalcitonin (PCT), ferritin, soluble tumor necrosis factor receptor type 1 (sTNFR1), and lactate dehydrogenase (LDH). Significant changes in serum levels were observed only later than 2 h after death for all markers. Inter-laboratory comparability was high, and intra-assay precision was sufficient for most markers. Most of the biomarker levels depended on the severity of hemolysis and lipemia but were robust against freeze-thaw cycles. Serum levels increased with longer post-mortem intervals for S100B, NSE, ferritin, sTNFR1, and LDH (for all
p
< 0.001) but decreased over this period for CRP (
p
= 0.089) and PCT (
p
< 0.001). Largely unchanged median values were found for GFAP (
p
= 0.139), BDNF (
p
= 0.106), and IL-6 (
p
= 0.094). Serum levels of CRP (
p
= 0.059) and LDH (
p
= 0.109) did not differ significantly between the final ante-mortem (resuscitation) and the first post-mortem sample (moment of death). Collecting the post-mortem blood sample as soon as possible will reduce the influence of post-mortem blood changes. Serum GFAP for detection of cerebral damage as well as serum IL-6 and CRP as proof of acute phase response seemed to be preferable due to their in situ stability in the first 2 days after death.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30167776</pmid><doi>10.1007/s00414-018-1925-2</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of legal medicine, 2019-05, Vol.133 (3), p.871-881 |
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| language | eng |
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| subjects | Acute-Phase Reaction Adult Aged Aged, 80 and over Biomarkers Biomarkers - blood Blood Brain Brain Injuries - blood Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood C-Reactive Protein - analysis Damage assessment Damage detection Death Female Ferritin Ferritins - blood Forensic Medicine Forensic pathology Freeze thaw cycles Glial Fibrillary Acidic Protein - blood Humans Immunoassay Interleukin-6 - blood Interleukins L-Lactate Dehydrogenase - blood Lactate dehydrogenase Male Medical Law Medicine & Public Health Middle Aged Original Article Phosphopyruvate Hydratase - blood Postmortem Changes Procalcitonin - blood Prospective Studies Proteins Receptors, Tumor Necrosis Factor, Type I - blood Resuscitation S100 Calcium Binding Protein beta Subunit - blood Stability |
| title | Post-mortem in situ stability of serum markers of cerebral damage and acute phase response |
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