Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer

Cyclin-dependent kinases (CDK) are considered to be potential targets of anticancer drugs that can interrupt the uncontrolled division of cancer cells. In this study, we selected two selective CDK inhibitors, AT7519 and SNS‑032, from current clinical trials and examined their anticancer and radiosen...

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Veröffentlicht in:	International journal of oncology 2018-08, Vol.53 (2), p.703-712
Hauptverfasser:	Kang, Mi Ae, Kim, Wonwoo, Jo, Hye-Ram, Shin, Young-Joo, Kim, Moon-Hong, Jeong, Jae-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Ataxia Cancer therapies Care and treatment Cell cycle Cervical cancer Chemotherapy Clinical trials Cyclin-dependent kinases Cytotoxicity Deoxyribonucleic acid Development and progression DNA DNA damage DNA repair Drug dosages Enzyme regulation Genetic aspects Health aspects Kinases Lung cancer Medical prognosis Metastasis Methods Patient outcomes Phosphorylation Phosphotransferases Radiotherapy Senescence Signal transduction Studies Tumors
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