MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1R

MicroRNAs (miRNAs) possess oncogenic and tumour‑suppressive roles in the carcinogenesis and progression of pancreatic ductal adenocarcinoma (PDAC) by regulating the expression of numerous cancer‑related genes. Thus, the investigation on the expression and roles of miRNAs in PDAC may facilitate the i...

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Veröffentlicht in:	Molecular medicine reports 2018-08, Vol.18 (2), p.1804-1811
Hauptverfasser:	Lin, Yongquan, Rong, Lihua, Zhao, Jingrong, Lin, Ronghui, Li, Shuhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Apoptosis Bladder cancer Bone cancer Cancer therapies Carcinogenesis Care and treatment Cell cycle Cell growth Cell proliferation Cell receptors Colonies Colorectal cancer Development and progression Gastric cancer Gene expression Genetic aspects Health aspects Innovations Insulin Insulin-like growth factors Kinases Liver cancer Lymph nodes Lymphatic system Medical prognosis Metastases Metastasis MicroRNA MicroRNAs miRNA Molecular targeted therapy Pancreas Pancreatic cancer Patients Prostate cancer Therapeutic applications Thyroid cancer Tumors
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