Different changes of the serum albumin cobalt-binding capacity induced by various oxidants

Impact of in vitro oxidative modification of the bovine serum albumin (BSA) on its cobaltbinding capacity (CoBC) was studied. We found various oxidants differently changed CoBC of BSA. The Fenton’s reagents producing hydroxyl radical decreased or not alter CoBC of BSA depending on composition of one...

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Veröffentlicht in:Vestnik Volgogradskogo gosudarstvennogo universiteta, Serii͡a︡ 11, Estestvennye nauki Serii͡a︡ 11, Estestvennye nauki, 2011-01 (2(2))
Hauptverfasser: Zaitsev, Valery Gennadyevich, Litus, Ekaterina Andreevna, Zhdanova, Anna Vitalyevna
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Zhdanova, Anna Vitalyevna
description Impact of in vitro oxidative modification of the bovine serum albumin (BSA) on its cobaltbinding capacity (CoBC) was studied. We found various oxidants differently changed CoBC of BSA. The Fenton’s reagents producing hydroxyl radical decreased or not alter CoBC of BSA depending on composition of ones. In contrast, treatment of BSA by hypochlorous acid, a physiological oxidant, elevated CoBC of this protein. Probable causes of different effects produced by various oxidants is discussed.
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subjects Bovine serum albumin
Cobalt
Hydroxyl radicals
Hypochlorous acid
Oxidants
Oxidation
title Different changes of the serum albumin cobalt-binding capacity induced by various oxidants
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