PGC1α promotes cisplatin resistance in human ovarian carcinoma cells through upregulation of mitochondrial biogenesis

The induction of lesions in nuclear and mitochondrial DNA by cisplatin is only a small component of its cytostatic/cytotoxic activity. The signaling pathway network in the nucleus and cytoplasm may contribute to chemotherapeutic resistance. Peroxisome proliferator-activated receptor-coactivator 1α (...

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Veröffentlicht in:	International journal of oncology 2018-07, Vol.53 (1), p.404-416
Hauptverfasser:	Shen, Luyan, Sun, Boyang, Sheng, Jiyao, Yu, Sihang, Li, Yanqing, Xu, Huadan, Su, Jing, Sun, Liankun
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Biosynthesis Breast cancer Cancer therapies Carcinoma - drug therapy Carcinoma - genetics Carcinoma - pathology Cell Line, Tumor Cell Survival - drug effects Chemotherapy Cisplatin - administration & dosage Cisplatin - adverse effects Cytochrome Drug Resistance, Neoplasm - genetics Female Gene Expression Regulation, Neoplastic - drug effects Genes Genomes Humans Hypotheses Kinases Lymphoma Medical prognosis Melanoma Metabolism Mitochondria Mitochondrial DNA Organelle Biogenesis Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Proteins Signal transduction Signal Transduction - drug effects Studies Toxicity Transcription factors Tumors
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