Randomized Study of Phentolamine Mesylate for Reversal of Local Anesthesia
Local anesthetic solutions frequently contain vasoconstrictors to increase the depth and/or duration of anesthesia. Generally, the duration of soft-tissue anesthesia exceeds that of pulpal anesthesia. Negative consequences of soft-tissue anesthesia include accidental lip and tongue biting as well as...
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| Veröffentlicht in: | Journal of dental research 2008-07, Vol.87 (7), p.635-639 |
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| container_title | Journal of dental research |
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| creator | Laviola, M. McGavin, S.K. Freer, G.A. Plancich, G. Woodbury, S.C. Marinkovich, S. Morrison, R. Reader, A. Rutherford, R.B. Yagiela, J.A. |
| description | Local anesthetic solutions frequently contain vasoconstrictors to increase the depth and/or duration of anesthesia. Generally, the duration of soft-tissue anesthesia exceeds that of pulpal anesthesia. Negative consequences of soft-tissue anesthesia include accidental lip and tongue biting as well as difficulty in eating, drinking, speaking, and smiling. A double-blind, randomized, multicenter, Phase 2 study tested the hypothesis that local injection of the vasodilator phentolamine mesylate would shorten the duration of soft-tissue anesthesia following routine dental procedures. Participants (122) received one or two cartridges of local anesthetic/vasoconstrictor prior to dental treatment. Immediately after treatment, 1.8 mL of study drug (containing 0.4 mg phentolamine mesylate or placebo) was injected per cartridge of local anesthetic used. The phentolamine was well-tolerated and reduced the median duration of soft-tissue anesthesia in the lip from 155 to 70 min (p < 0.0001). |
| doi_str_mv | 10.1177/154405910808700717 |
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Generally, the duration of soft-tissue anesthesia exceeds that of pulpal anesthesia. Negative consequences of soft-tissue anesthesia include accidental lip and tongue biting as well as difficulty in eating, drinking, speaking, and smiling. A double-blind, randomized, multicenter, Phase 2 study tested the hypothesis that local injection of the vasodilator phentolamine mesylate would shorten the duration of soft-tissue anesthesia following routine dental procedures. Participants (122) received one or two cartridges of local anesthetic/vasoconstrictor prior to dental treatment. Immediately after treatment, 1.8 mL of study drug (containing 0.4 mg phentolamine mesylate or placebo) was injected per cartridge of local anesthetic used. The phentolamine was well-tolerated and reduced the median duration of soft-tissue anesthesia in the lip from 155 to 70 min (p < 0.0001).</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/154405910808700717</identifier><identifier>PMID: 18573982</identifier><identifier>CODEN: JDREAF</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>Adolescent ; Adrenergic alpha-Antagonists - pharmacology ; Adult ; Anesthesia, Dental - methods ; Anesthetics, Local - administration & dosage ; Child ; Double-Blind Method ; Drug Combinations ; Drug Interactions ; Female ; Humans ; Kaplan-Meier Estimate ; Lip - drug effects ; Male ; Middle Aged ; Mouth - drug effects ; Phentolamine - pharmacology ; Prospective Studies ; Recovery of Function - drug effects ; Reference Values ; Sensation - drug effects ; Time Factors ; Touch - drug effects ; Vasoconstrictor Agents - administration & dosage</subject><ispartof>Journal of dental research, 2008-07, Vol.87 (7), p.635-639</ispartof><rights>International and American Associations for Dental Research</rights><rights>Copyright American Association for Dental Research/American Academy of Implant Dentistry Jul 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-cf6601e1d09f93fb7b01c8248887c5b2c17e5685b6cebc43a807bd464a2753dd3</citedby><cites>FETCH-LOGICAL-c397t-cf6601e1d09f93fb7b01c8248887c5b2c17e5685b6cebc43a807bd464a2753dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/154405910808700717$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/154405910808700717$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18573982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laviola, M.</creatorcontrib><creatorcontrib>McGavin, S.K.</creatorcontrib><creatorcontrib>Freer, G.A.</creatorcontrib><creatorcontrib>Plancich, G.</creatorcontrib><creatorcontrib>Woodbury, S.C.</creatorcontrib><creatorcontrib>Marinkovich, S.</creatorcontrib><creatorcontrib>Morrison, R.</creatorcontrib><creatorcontrib>Reader, A.</creatorcontrib><creatorcontrib>Rutherford, R.B.</creatorcontrib><creatorcontrib>Yagiela, J.A.</creatorcontrib><title>Randomized Study of Phentolamine Mesylate for Reversal of Local Anesthesia</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>Local anesthetic solutions frequently contain vasoconstrictors to increase the depth and/or duration of anesthesia. Generally, the duration of soft-tissue anesthesia exceeds that of pulpal anesthesia. Negative consequences of soft-tissue anesthesia include accidental lip and tongue biting as well as difficulty in eating, drinking, speaking, and smiling. A double-blind, randomized, multicenter, Phase 2 study tested the hypothesis that local injection of the vasodilator phentolamine mesylate would shorten the duration of soft-tissue anesthesia following routine dental procedures. Participants (122) received one or two cartridges of local anesthetic/vasoconstrictor prior to dental treatment. Immediately after treatment, 1.8 mL of study drug (containing 0.4 mg phentolamine mesylate or placebo) was injected per cartridge of local anesthetic used. The phentolamine was well-tolerated and reduced the median duration of soft-tissue anesthesia in the lip from 155 to 70 min (p < 0.0001).</description><subject>Adolescent</subject><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Adult</subject><subject>Anesthesia, Dental - methods</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Child</subject><subject>Double-Blind Method</subject><subject>Drug Combinations</subject><subject>Drug Interactions</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lip - drug effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth - drug effects</subject><subject>Phentolamine - pharmacology</subject><subject>Prospective Studies</subject><subject>Recovery of Function - drug effects</subject><subject>Reference Values</subject><subject>Sensation - drug effects</subject><subject>Time Factors</subject><subject>Touch - drug effects</subject><subject>Vasoconstrictor Agents - 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Generally, the duration of soft-tissue anesthesia exceeds that of pulpal anesthesia. Negative consequences of soft-tissue anesthesia include accidental lip and tongue biting as well as difficulty in eating, drinking, speaking, and smiling. A double-blind, randomized, multicenter, Phase 2 study tested the hypothesis that local injection of the vasodilator phentolamine mesylate would shorten the duration of soft-tissue anesthesia following routine dental procedures. Participants (122) received one or two cartridges of local anesthetic/vasoconstrictor prior to dental treatment. Immediately after treatment, 1.8 mL of study drug (containing 0.4 mg phentolamine mesylate or placebo) was injected per cartridge of local anesthetic used. The phentolamine was well-tolerated and reduced the median duration of soft-tissue anesthesia in the lip from 155 to 70 min (p < 0.0001).</abstract><cop>United States</cop><pub>SAGE Publications</pub><pmid>18573982</pmid><doi>10.1177/154405910808700717</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adrenergic alpha-Antagonists - pharmacology Adult Anesthesia, Dental - methods Anesthetics, Local - administration & dosage Child Double-Blind Method Drug Combinations Drug Interactions Female Humans Kaplan-Meier Estimate Lip - drug effects Male Middle Aged Mouth - drug effects Phentolamine - pharmacology Prospective Studies Recovery of Function - drug effects Reference Values Sensation - drug effects Time Factors Touch - drug effects Vasoconstrictor Agents - administration & dosage |
| title | Randomized Study of Phentolamine Mesylate for Reversal of Local Anesthesia |
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