Osteonecrosis of the Jaws and Bisphosphonate Therapy
Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. The efficacy of these agents in treating and preventing the significant skeletal complications associated with these conditions has had a major positive impact for patients and is responsible for their wi...
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| Veröffentlicht in: | Journal of dental research 2007-11, Vol.86 (11), p.1013-1021 |
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| container_title | Journal of dental research |
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| creator | Ruggiero, S.L. Drew, S.J. |
| description | Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. The efficacy of these agents in treating and preventing the significant skeletal complications associated with these conditions has had a major positive impact for patients and is responsible for their widespread use in medicine. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. Based on a growing number of case reports and institutional reviews, bisphosphonate therapy may cause exposed and necrotic bone that is isolated to the jaw. This complication usually presents following simple dento-alveolar surgery, and can cause a significant adverse effect on the quality of life for most patients. The pathogenesis for this complication appears to be related to the profound inhibition of osteoclast function and bone remodeling. |
| doi_str_mv | 10.1177/154405910708601101 |
| format | Article |
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| subjects | Anti-Bacterial Agents - therapeutic use Bone Density Conservation Agents - adverse effects Bone Neoplasms - drug therapy Diphosphonates - adverse effects Female Humans Jaw Diseases - chemically induced Jaw Diseases - drug therapy Jaw Diseases - pathology Multiple Myeloma - drug therapy Osteonecrosis - chemically induced Osteonecrosis - drug therapy Osteonecrosis - pathology Osteoporosis, Postmenopausal - prevention & control |
| title | Osteonecrosis of the Jaws and Bisphosphonate Therapy |
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