Angiogenic Signaling Triggered by Cariogenic Bacteria in Pulp Cells

The inflammation observed in the dental pulp of teeth with deep caries lesions is characterized by a significant increase in blood vessel density. It is known that lipoteichoic acid (LTA) from Gram-positive cariogenic bacteria induces expression of vascular endothelial growth factor (VEGF) in dental...

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Veröffentlicht in:	Journal of dental research 2009-09, Vol.88 (9), p.835-840
Hauptverfasser:	Soden, R.I., Botero, T.M., Hanks, C.T., Nör, J.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Dental Caries - microbiology Dental Pulp - blood supply Dental Pulp - cytology Dental Pulp - microbiology Fibroblasts - drug effects Gingiva - cytology Gingiva - drug effects I-kappa B Kinase - analysis I-kappa B Kinase - drug effects Lipopolysaccharides - pharmacology Macrophages - drug effects Mice Microvessels - drug effects Microvessels - pathology Neovascularization, Physiologic - physiology Odontoblasts - drug effects Phosphatidylinositol 3-Kinases - analysis Phosphatidylinositol 3-Kinases - drug effects Proto-Oncogene Proteins c-akt - analysis Proto-Oncogene Proteins c-akt - drug effects Pulpitis - microbiology Pulpitis - pathology Signal Transduction - physiology Streptococcus sanguis - physiology Teichoic Acids - pharmacology Toll-Like Receptor 2 - analysis Toll-Like Receptor 2 - drug effects Up-Regulation Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - drug effects Vascular Endothelial Growth Factor Receptor-2 - analysis Vascular Endothelial Growth Factor Receptor-2 - drug effects
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