Comprehensive bile acid profiling in hereditary intrahepatic cholestasis: Genetic and clinical correlations

Background & Aims Genetic defects causing dysfunction in bile salt export pump (BSEP/ABCB11) lead to liver diseases. ABCB11 mutations alter the bile acid metabolome. We asked whether profiling plasma bile acids could reveal compensatory mechanisms and track genetic and clinical status. Methods W...

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Veröffentlicht in:	Liver international 2018-09, Vol.38 (9), p.1676-1685
Hauptverfasser:	Liu, Teng, Wang, Ren‐Xue, Han, Jun, Hao, Chen‐Zhi, Qiu, Yi‐Ling, Yan, Yan‐Yan, Li, Li‐Ting, Wang, Neng‐Li, Gong, Jing‐Yu, Lu, Yi, Zhang, Mei‐Hong, Xie, Xin‐Bao, Yang, Jun‐Cong, You, Yi‐Jie, Li, Jia‐qi, Knisely, A. S., Borchers, Christoph H., Ling, Victor, Wang, Jian‐She
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCB11 Acids Bile Bile acids bile salt export pump Cholestasis Diagnostic systems Gallbladder diseases Hydrophobicity Liquid chromatography liquid chromatography‐mass spectrometry Liver Liver diseases Mass spectrometry Mass spectroscopy Mutation Patients PFIC2 Secretion Toxicity
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