An Experimental Study of the Pharmacokinetics of the Antitumor Drug Aurumacryl
The distribution of the antitumor drug aurumacryl (intraperitoneally injected at a dose of 100 mg/kg) in the bodies of animals with Lewis lung carcinoma was studied. The determination of aurumacryl in the tumors and organs (blood, liver, kidneys, lungs, spleen, and brain) of mice was carried out for...
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| Veröffentlicht in: | Biophysics (Oxford) 2018-05, Vol.63 (3), p.469-476 |
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| creator | Ostrovskaya, L. A. Korman, D. B. Burmiy, J. P. Kuzmin, V. A. Bluhterova, N. V. Fomina, M. M. Rikova, V. A. Guliev, R. R. Abzaeva, K. A. |
| description | The distribution of the antitumor drug aurumacryl (intraperitoneally injected at a dose of 100 mg/kg) in the bodies of animals with Lewis lung carcinoma was studied. The determination of aurumacryl in the tumors and organs (blood, liver, kidneys, lungs, spleen, and brain) of mice was carried out for 48 h by measuring the gold content in the test tissues using inductively coupled plasma mass spectrometry. We found the preferential accumulation of the drug in the kidneys with an extremely low gold content in the brain and a relatively uniform distribution of aurumacryl between the tumor, liver, lung, and spleen tissues. |
| doi_str_mv | 10.1134/S0006350918030181 |
| format | Article |
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A. ; Korman, D. B. ; Burmiy, J. P. ; Kuzmin, V. A. ; Bluhterova, N. V. ; Fomina, M. M. ; Rikova, V. A. ; Guliev, R. R. ; Abzaeva, K. A.</creator><creatorcontrib>Ostrovskaya, L. A. ; Korman, D. B. ; Burmiy, J. P. ; Kuzmin, V. A. ; Bluhterova, N. V. ; Fomina, M. M. ; Rikova, V. A. ; Guliev, R. R. ; Abzaeva, K. A.</creatorcontrib><description>The distribution of the antitumor drug aurumacryl (intraperitoneally injected at a dose of 100 mg/kg) in the bodies of animals with Lewis lung carcinoma was studied. The determination of aurumacryl in the tumors and organs (blood, liver, kidneys, lungs, spleen, and brain) of mice was carried out for 48 h by measuring the gold content in the test tissues using inductively coupled plasma mass spectrometry. We found the preferential accumulation of the drug in the kidneys with an extremely low gold content in the brain and a relatively uniform distribution of aurumacryl between the tumor, liver, lung, and spleen tissues.</description><identifier>ISSN: 0006-3509</identifier><identifier>EISSN: 1555-6654</identifier><identifier>DOI: 10.1134/S0006350918030181</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biological and Medical Physics ; Biophysics ; Complex Systems Biophysics ; Kidneys ; Liver ; Lung cancer ; Lung carcinoma ; Mass spectroscopy ; Pharmacokinetics ; Physics ; Physics and Astronomy ; Spleen ; Tumors</subject><ispartof>Biophysics (Oxford), 2018-05, Vol.63 (3), p.469-476</ispartof><rights>Pleiades Publishing, Inc. 2018</rights><rights>Biophysics is a copyright of Springer, (2018). 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| subjects | Biological and Medical Physics Biophysics Complex Systems Biophysics Kidneys Liver Lung cancer Lung carcinoma Mass spectroscopy Pharmacokinetics Physics Physics and Astronomy Spleen Tumors |
| title | An Experimental Study of the Pharmacokinetics of the Antitumor Drug Aurumacryl |
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