Role of conformational entropy in force-induced bio-polymer unfolding

Role of conformational entropy in force-induced bio-polymer unfolding

A statistical mechanical description of flexible and semi-flexible polymer chains in a poor solvent is developed in the constant force and constant distance ensembles. We predict the existence of many intermediate states at low temperatures stabilized by the force. A unified response to pulling and...

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Veröffentlicht in:arXiv.org 2007-02
Hauptverfasser: Kumar, Sanjay, Jensen, Iwan, Jacobsen, Jesper L, Guttmann, Anthony J
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Biopolymers
Crossovers
Polymers
Proteins
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Jensen, Iwan
Jacobsen, Jesper L
Guttmann, Anthony J
description A statistical mechanical description of flexible and semi-flexible polymer chains in a poor solvent is developed in the constant force and constant distance ensembles. We predict the existence of many intermediate states at low temperatures stabilized by the force. A unified response to pulling and compressing forces has been obtained in the constant distance ensemble. We show the signature of a cross-over length which increases linearly with the chain length. Below this cross-over length, the critical force of unfolding decreases with temperature, while above, it increases with temperature. For stiff chains, we report for the first time "saw-tooth" like behavior in the force-extension curves which has been seen earlier in the case of protein unfolding.
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subjects Biopolymers
Crossovers
Polymers
Proteins
title Role of conformational entropy in force-induced bio-polymer unfolding
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