Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth

Treatment with heat-stable carbetocin after vaginal delivery was noninferior to oxytocin for prevention of blood loss of at least 500 ml or use of uterotonics. Noninferiority was not shown for prevention of blood loss of at least 1000 ml, but event rates were low.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-08, Vol.379 (8), p.743-752
Hauptverfasser:	Widmer, Mariana, Piaggio, Gilda, Nguyen, Thi M.H, Osoti, Alfred, Owa, Olorunfemi O, Misra, Sujata, Coomarasamy, Arri, Abdel-Aleem, Hany, Mallapur, Ashalata A, Qureshi, Zahida, Lumbiganon, Pisake, Patel, Archana B, Carroli, Guillermo, Fawole, Bukola, Goudar, Shivaprasad S, Pujar, Yeshita V, Neilson, James, Hofmeyr, G. Justus, Su, Lin L, Ferreira de Carvalho, Jose, Pandey, Uma, Mugerwa, Kidza, Shiragur, Shobha S, Byamugisha, Josaphat, Giordano, Daniel, Gülmezoglu, A. Metin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Birth Blood Childbirth & labor Clinical trials Cold storage Double-Blind Method Drug dosages Drug Stability Female Heat Hemorrhage Humans Injections, Intramuscular Maternal mortality Oxytocics - adverse effects Oxytocics - therapeutic use Oxytocin Oxytocin - adverse effects Oxytocin - analogs & derivatives Oxytocin - therapeutic use Pharmaceuticals Postpartum Postpartum Hemorrhage - prevention & control Pregnancy Prevention Risk Risk assessment Thermal stability Vagina Womens health Young Adult
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Beschreibung
Zusammenfassung:	Treatment with heat-stable carbetocin after vaginal delivery was noninferior to oxytocin for prevention of blood loss of at least 500 ml or use of uterotonics. Noninferiority was not shown for prevention of blood loss of at least 1000 ml, but event rates were low.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1805489