Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis

Dehydroabietic acid (DHA) is one of the main constituents of the resin that have antiprotozoal activity against Leishmania spp., but the leishmanicidal mechanism is unknown. The objective of the study was to investigate in vitro the leishmanicidal activity of the natural compound DHA against intrace...

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Veröffentlicht in:	Fitoterapia 2018-07, Vol.128, p.224-232
Hauptverfasser:	Gonçalves, Manoela Daiele, Bortoleti, B.T.S., Tomiotto-Pellissier, Fernanda, Miranda-Sapla, Milena Menegazzo, Assolini, João Paulo, Carloto, Amanda Cristina Machado, Carvalho, P.G.C., Tudisco, Ellen Takasse, Urbano, Alexandre, Ambrósio, Sérgio Ricardo, Hirooka, Elisa Yoko, Simão, Andréa Name Colado, Costa, Idessania Nazareth, Pavanelli, Wander Rogério, Conchon-Costa, Ivete, Arakawa, Nilton Syogo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amastigotes Antiprotozoal activity Apoptosis Cell death Cytokines Cytotoxicity Cytotoxity Dehydroabietic acid Depolarization Diterpene Ferritin Fluorescence Intracellular Iodides Iron Iron and steel making Iron constituents Leishmanicidal activity Macrophages Mitochondria Morphology Nitric oxide Oxidizing agents Phosphatidylserine Pine trees Pinus elliottii Polyimide resins Promastigotes Propidium iodide Reactive oxygen species Resin acid Scanning electron microscopy Trees
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