Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation

RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and decay. Guanylation of the poly(A) tail was discovered recently, yet the enzymology and function remain obscure. Here we identify TENT4A (PAPD7) and TENT4B (PAPD5) as the enzymes responsible for mRNA guanylation....

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-08, Vol.361 (6403), p.701-704
Hauptverfasser:	Lim, Jaechul, Kim, Dongwan, Lee, Young-Suk, Ha, Minju, Lee, Mihye, Yeo, Jinah, Chang, Hyeshik, Song, Jaewon, Ahn, Kwangseog, Kim, V Narry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Complexity DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Enzymes Enzymology Exoribonucleases - metabolism Fibroblasts Gene Deletion Gene expression Gene Expression Regulation Gene Knockout Techniques Gene regulation Guanosine HEK293 Cells HeLa Cells Humans mRNA mRNA stability mRNA turnover Nucleotides Polyadenine Polyadenylation Post-transcription Proteins Residues Ribonucleic acid RNA RNA 3' End Processing RNA Nucleotidyltransferases - genetics RNA Nucleotidyltransferases - metabolism RNA, Messenger - metabolism Shields
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