Melatonin increases both life span and tumor incidence in female CBA mice
From the age of 6 months until their natural deaths, female CBA mice were given melatonin with their drinking water (20 mg/l) for 5 consecutive days every month. Intact mice served as controls. The results of this study show that the consumption of melatonin did not significantly influence food cons...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2001-07, Vol.56 (7), p.B311-B323 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
| container_volume | 56 |
| creator | Anisimov, V N Zavarzina, N Y Zabezhinski, M A Popovich, I G Zimina, O A Shtylick, A V Arutjunyan, A V Oparina, T I Prokopenko, V M Mikhalski, A I Yashin, A I |
| description | From the age of 6 months until their natural deaths, female CBA mice were given melatonin with their drinking water (20 mg/l) for 5 consecutive days every month. Intact mice served as controls. The results of this study show that the consumption of melatonin did not significantly influence food consumption, but it did increase the body weight of older mice; it did not influence physical strength or the presence of fatigue; it decreased locomotor activity and body temperature; it inhibited free radical processes in serum, brain, and liver; it slowed down the age-related switching-off of estrous function; and it increased life span. However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice. For this reason, we concluded that it would be premature to recommend melatonin as a geroprotector for long-term use. |
| doi_str_mv | 10.1093/gerona/56.7.B311 |
| format | Article |
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Intact mice served as controls. The results of this study show that the consumption of melatonin did not significantly influence food consumption, but it did increase the body weight of older mice; it did not influence physical strength or the presence of fatigue; it decreased locomotor activity and body temperature; it inhibited free radical processes in serum, brain, and liver; it slowed down the age-related switching-off of estrous function; and it increased life span. However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice. For this reason, we concluded that it would be premature to recommend melatonin as a geroprotector for long-term use.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/56.7.B311</identifier><identifier>PMID: 11445596</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aging ; Aging - drug effects ; Aging - physiology ; Animals ; Body Weight - drug effects ; Brain - metabolism ; Drugs ; Estrus - drug effects ; Experiments ; Female ; Free Radicals - blood ; Free Radicals - metabolism ; Incidence ; Liver - metabolism ; Locomotion - drug effects ; Longevity - drug effects ; Medical research ; Melatonin - adverse effects ; Melatonin - pharmacology ; Melatonin - physiology ; Mice ; Mice, Inbred CBA ; Models, Theoretical ; Neoplasms - chemically induced ; Rodents</subject><ispartof>The journals of gerontology. 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Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>From the age of 6 months until their natural deaths, female CBA mice were given melatonin with their drinking water (20 mg/l) for 5 consecutive days every month. Intact mice served as controls. The results of this study show that the consumption of melatonin did not significantly influence food consumption, but it did increase the body weight of older mice; it did not influence physical strength or the presence of fatigue; it decreased locomotor activity and body temperature; it inhibited free radical processes in serum, brain, and liver; it slowed down the age-related switching-off of estrous function; and it increased life span. However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice. For this reason, we concluded that it would be premature to recommend melatonin as a geroprotector for long-term use.</description><subject>Aging</subject><subject>Aging - drug effects</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Brain - metabolism</subject><subject>Drugs</subject><subject>Estrus - drug effects</subject><subject>Experiments</subject><subject>Female</subject><subject>Free Radicals - blood</subject><subject>Free Radicals - metabolism</subject><subject>Incidence</subject><subject>Liver - metabolism</subject><subject>Locomotion - drug effects</subject><subject>Longevity - drug effects</subject><subject>Medical research</subject><subject>Melatonin - adverse effects</subject><subject>Melatonin - pharmacology</subject><subject>Melatonin - physiology</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Models, Theoretical</subject><subject>Neoplasms - chemically induced</subject><subject>Rodents</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL1PwzAUxC0EolDYmZDFntYvjr_GtuKjUhELSGyW475AqsYpdjLw35OolXjL3XB3T_oRcgdsBszw-RfGNri5kDM1W3KAM3IFSuhMcPF5PnimTCYYkxNyndKOjSfySzIBKAohjLwi61fcu64NdaB18BFdwkTLtvum-7pCmg4uUBe2tOubNo6ReovB4-BohY3bI10tF7SpPd6Qi8rtE96edEo-nh7fVy_Z5u15vVpsMl8AdJmRaIysmPAgK280095rVIVXZc5yzrVTpda-1DkoKJVxqgDhneRS8VyC51PycNw9xPanx9TZXdvHMLy0OdOSFwOYIcSOIR_blCJW9hDrxsVfC8yO6OwRnRXSKjuiGyr3p92-bHD7Xzix4n_imml6</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Anisimov, V N</creator><creator>Zavarzina, N Y</creator><creator>Zabezhinski, M A</creator><creator>Popovich, I G</creator><creator>Zimina, O A</creator><creator>Shtylick, A V</creator><creator>Arutjunyan, A V</creator><creator>Oparina, T I</creator><creator>Prokopenko, V M</creator><creator>Mikhalski, A I</creator><creator>Yashin, A I</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20010701</creationdate><title>Melatonin increases both life span and tumor incidence in female CBA mice</title><author>Anisimov, V N ; Zavarzina, N Y ; Zabezhinski, M A ; Popovich, I G ; Zimina, O A ; Shtylick, A V ; Arutjunyan, A V ; Oparina, T I ; Prokopenko, V M ; Mikhalski, A I ; Yashin, A I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-96e996f05c16fc9808cc8e74c7b202338a7b88cb82171b79a7415ca63673261c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aging</topic><topic>Aging - drug effects</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Brain - metabolism</topic><topic>Drugs</topic><topic>Estrus - drug effects</topic><topic>Experiments</topic><topic>Female</topic><topic>Free Radicals - blood</topic><topic>Free Radicals - metabolism</topic><topic>Incidence</topic><topic>Liver - metabolism</topic><topic>Locomotion - drug effects</topic><topic>Longevity - drug effects</topic><topic>Medical research</topic><topic>Melatonin - adverse effects</topic><topic>Melatonin - pharmacology</topic><topic>Melatonin - physiology</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Models, Theoretical</topic><topic>Neoplasms - chemically induced</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anisimov, V N</creatorcontrib><creatorcontrib>Zavarzina, N Y</creatorcontrib><creatorcontrib>Zabezhinski, M A</creatorcontrib><creatorcontrib>Popovich, I G</creatorcontrib><creatorcontrib>Zimina, O A</creatorcontrib><creatorcontrib>Shtylick, A V</creatorcontrib><creatorcontrib>Arutjunyan, A V</creatorcontrib><creatorcontrib>Oparina, T I</creatorcontrib><creatorcontrib>Prokopenko, V M</creatorcontrib><creatorcontrib>Mikhalski, A I</creatorcontrib><creatorcontrib>Yashin, A I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The journals of gerontology. 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| identifier | ISSN: 1079-5006 |
| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 2001-07, Vol.56 (7), p.B311-B323 |
| issn | 1079-5006 1758-535X |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Aging Aging - drug effects Aging - physiology Animals Body Weight - drug effects Brain - metabolism Drugs Estrus - drug effects Experiments Female Free Radicals - blood Free Radicals - metabolism Incidence Liver - metabolism Locomotion - drug effects Longevity - drug effects Medical research Melatonin - adverse effects Melatonin - pharmacology Melatonin - physiology Mice Mice, Inbred CBA Models, Theoretical Neoplasms - chemically induced Rodents |
| title | Melatonin increases both life span and tumor incidence in female CBA mice |
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