Age-related Base Excision Repair Activity in Mouse Brain and Liver Nuclear Extracts

To assess DNA repair activity relative to age, in vitro base excision repair assays were performed using brain and liver nuclear extracts prepared from mice of various ages. An 85% decline in repair activity was observed in brain nuclear extracts and a 50% decrease in liver nuclear extracts prepared...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2003-03, Vol.58 (3), p.B205-B211
Hauptverfasser:	Intano, Gabriel W., Cho, Eun Ju, McMahan, C. Alex, Walter, Christi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - genetics Aging - metabolism Animals Blotting, Western Brain Brain - metabolism Cell Nucleus - metabolism Deoxyribonucleic acid DNA DNA Glycosylases DNA Ligases - pharmacology DNA Polymerase beta - metabolism DNA Repair Liver Liver - metabolism Male Mice Mice, Inbred Strains N-Glycosyl Hydrolases - metabolism Rodents Uracil-DNA Glycosidase
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