Muscle Regeneration in Young and Old Rats: Effects of Motor Nerve Transection With and Without Marcaine Treatment
We tested the hypothesis that after skeletal muscle regeneration in old compared with young rats damage to the motor nerve rather titan damage to muscle fibers determines the magnitude of the deficits in muscle mass and maximum force (P0) The mass and P0 of extensor digitorum longus (EDL) muscles of...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 1998-01, Vol.53A (1), p.B52-B58 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Carlson, Bruce M. Faulkner, John A. |
| description | We tested the hypothesis that after skeletal muscle regeneration in old compared with young rats damage to the motor nerve rather titan damage to muscle fibers determines the magnitude of the deficits in muscle mass and maximum force (P0) The mass and P0 of extensor digitorum longus (EDL) muscles of young (4 months) and old (24 months) male rats were compared two months following (i) Marcaine treatment plus simultaneous motor nerve transection, (ii) motor nerve transection alone, and (iii) Marcaine treatment alone (from data compiled previously). In both the nerve transection-only and Marcaine with nerve transection groups the recovery of mass and P0 was significantly greater in young than in old rats. This is in contrast to our previous data showing that in the absence of nerve damage Marcaine-treated muscle in old rats regenerates as well as that in young rats. Our hypothesis was supported, and we conclude that impaired axonal regeneration, re-establishment of nerve-muscle contact, or both, is the critical component in the impaired regeneration of muscle grafts in old as compared with young rats. |
| doi_str_mv | 10.1093/gerona/53A.1.B52 |
| format | Article |
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In both the nerve transection-only and Marcaine with nerve transection groups the recovery of mass and P0 was significantly greater in young than in old rats. This is in contrast to our previous data showing that in the absence of nerve damage Marcaine-treated muscle in old rats regenerates as well as that in young rats. Our hypothesis was supported, and we conclude that impaired axonal regeneration, re-establishment of nerve-muscle contact, or both, is the critical component in the impaired regeneration of muscle grafts in old as compared with young rats.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/53A.1.B52</identifier><identifier>PMID: 9467423</identifier><language>eng</language><publisher>United States: The Gerontological Society of America</publisher><subject>Aging ; Aging - physiology ; Analysis of Variance ; Anesthetics, Local - adverse effects ; Animals ; Axons - drug effects ; Axons - physiology ; Bupivacaine - adverse effects ; Linear Models ; Male ; Motor Neurons - drug effects ; Motor Neurons - physiology ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; Muscle Fibers, Skeletal - drug effects ; Muscle Fibers, Skeletal - physiology ; Muscle, Skeletal - anatomy & histology ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiology ; Muscular Atrophy - etiology ; Muscular Atrophy - pathology ; Muscular Atrophy - physiopathology ; Muscular system ; Nerve Regeneration - drug effects ; Nerve Regeneration - physiology ; Nervous system ; Rats ; Rats, Inbred Strains ; Rats, Wistar ; Regeneration - drug effects ; Regeneration - physiology ; Rodents</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 1998-01, Vol.53A (1), p.B52-B58</ispartof><rights>Copyright Gerontological Society of America, Incorporated Jan 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-f6df73c87b797a9eafa578dc6008592d9b875af1385024cfd05f17e5d1d265ec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27852,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9467423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlson, Bruce M.</creatorcontrib><creatorcontrib>Faulkner, John A.</creatorcontrib><title>Muscle Regeneration in Young and Old Rats: Effects of Motor Nerve Transection With and Without Marcaine Treatment</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>We tested the hypothesis that after skeletal muscle regeneration in old compared with young rats damage to the motor nerve rather titan damage to muscle fibers determines the magnitude of the deficits in muscle mass and maximum force (P0) The mass and P0 of extensor digitorum longus (EDL) muscles of young (4 months) and old (24 months) male rats were compared two months following (i) Marcaine treatment plus simultaneous motor nerve transection, (ii) motor nerve transection alone, and (iii) Marcaine treatment alone (from data compiled previously). In both the nerve transection-only and Marcaine with nerve transection groups the recovery of mass and P0 was significantly greater in young than in old rats. This is in contrast to our previous data showing that in the absence of nerve damage Marcaine-treated muscle in old rats regenerates as well as that in young rats. Our hypothesis was supported, and we conclude that impaired axonal regeneration, re-establishment of nerve-muscle contact, or both, is the critical component in the impaired regeneration of muscle grafts in old as compared with young rats.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>Anesthetics, Local - adverse effects</subject><subject>Animals</subject><subject>Axons - drug effects</subject><subject>Axons - physiology</subject><subject>Bupivacaine - adverse effects</subject><subject>Linear Models</subject><subject>Male</subject><subject>Motor Neurons - drug effects</subject><subject>Motor Neurons - physiology</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle Fibers, Skeletal - drug effects</subject><subject>Muscle Fibers, Skeletal - physiology</subject><subject>Muscle, Skeletal - anatomy & histology</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscular Atrophy - etiology</subject><subject>Muscular Atrophy - pathology</subject><subject>Muscular Atrophy - physiopathology</subject><subject>Muscular system</subject><subject>Nerve Regeneration - drug effects</subject><subject>Nerve Regeneration - physiology</subject><subject>Nervous system</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Wistar</subject><subject>Regeneration - drug effects</subject><subject>Regeneration - physiology</subject><subject>Rodents</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp1kc1vEzEQxVcIVErhzgXJgvOm_livbW5tVRqkpkVREYWL5djjsCWxW9uLyn-Pl0S9MZcZ6f3es-TXNG8JnhGs2PEaUgzmmLOTGZmdcvqsOSSCy5Yzfvu83liolmPcv2xe5XyHp-H0oDlQXS86yg6bh8WY7QbQEtYQIJkyxICGgL7HMayRCQ5dbxxampI_onPvwZaMokeLWGJCV5B-A7pJJuQqTM5vQ_n5zzUdcSxoYZI1Q5goMGULobxuXnizyfBmv4-ar5_Ob87m7eX1xeezk8vWdlSV1vfOC2alWAkljALjDRfS2R5jyRV1aiUFN54wyTHtrHeYeyKAO-Joz8Gyo-b9Lvc-xYcRctF3cUyhPqkplj1RgosKffgfRKQQhHWSsUrhHWVTzDmB1_dp2Jr0RxOspx70rgdde9BE1x6q5d0-eFxtwT0Z9h9f9XanD7nA45Ns0i_dCya4nt_-0FR-6ZdXbF5z_wKqjJPg</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Carlson, Bruce M.</creator><creator>Faulkner, John A.</creator><general>The Gerontological Society of America</general><general>Gerontological Society of America</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOIBA</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>199801</creationdate><title>Muscle Regeneration in Young and Old Rats: Effects of Motor Nerve Transection With and Without Marcaine Treatment</title><author>Carlson, Bruce M. ; Faulkner, John A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-f6df73c87b797a9eafa578dc6008592d9b875af1385024cfd05f17e5d1d265ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aging</topic><topic>Aging - 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drug effects</topic><topic>Regeneration - physiology</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carlson, Bruce M.</creatorcontrib><creatorcontrib>Faulkner, John A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 29</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - 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Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carlson, Bruce M.</au><au>Faulkner, John A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscle Regeneration in Young and Old Rats: Effects of Motor Nerve Transection With and Without Marcaine Treatment</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>1998-01</date><risdate>1998</risdate><volume>53A</volume><issue>1</issue><spage>B52</spage><epage>B58</epage><pages>B52-B58</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>We tested the hypothesis that after skeletal muscle regeneration in old compared with young rats damage to the motor nerve rather titan damage to muscle fibers determines the magnitude of the deficits in muscle mass and maximum force (P0) The mass and P0 of extensor digitorum longus (EDL) muscles of young (4 months) and old (24 months) male rats were compared two months following (i) Marcaine treatment plus simultaneous motor nerve transection, (ii) motor nerve transection alone, and (iii) Marcaine treatment alone (from data compiled previously). In both the nerve transection-only and Marcaine with nerve transection groups the recovery of mass and P0 was significantly greater in young than in old rats. This is in contrast to our previous data showing that in the absence of nerve damage Marcaine-treated muscle in old rats regenerates as well as that in young rats. Our hypothesis was supported, and we conclude that impaired axonal regeneration, re-establishment of nerve-muscle contact, or both, is the critical component in the impaired regeneration of muscle grafts in old as compared with young rats.</abstract><cop>United States</cop><pub>The Gerontological Society of America</pub><pmid>9467423</pmid><doi>10.1093/gerona/53A.1.B52</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-5006 |
| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 1998-01, Vol.53A (1), p.B52-B58 |
| issn | 1079-5006 1758-535X |
| language | eng |
| recordid | cdi_proquest_journals_208619757 |
| source | MEDLINE; Periodicals Index Online; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aging Aging - physiology Analysis of Variance Anesthetics, Local - adverse effects Animals Axons - drug effects Axons - physiology Bupivacaine - adverse effects Linear Models Male Motor Neurons - drug effects Motor Neurons - physiology Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - physiology Muscle, Skeletal - anatomy & histology Muscle, Skeletal - drug effects Muscle, Skeletal - innervation Muscle, Skeletal - physiology Muscular Atrophy - etiology Muscular Atrophy - pathology Muscular Atrophy - physiopathology Muscular system Nerve Regeneration - drug effects Nerve Regeneration - physiology Nervous system Rats Rats, Inbred Strains Rats, Wistar Regeneration - drug effects Regeneration - physiology Rodents |
| title | Muscle Regeneration in Young and Old Rats: Effects of Motor Nerve Transection With and Without Marcaine Treatment |
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