Effects of BPA on global DNA methylation and global histone 3 lysine modifications in SH-SY5Y cells: An epigenetic mechanism linking the regulation of chromatin modifiying genes

Bisphenol A (BPA), an estrogenic endocrine disruptor, is widely used in the production of polycarbonate plastic and epoxy resins, resulting in high risk on human health. In present study we aimed to investigate the effects of BPA on global and gene specific DNA methylation, global histone modificati...

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Veröffentlicht in:	Toxicology in vitro 2017-10, Vol.44, p.313-321
Hauptverfasser:	Senyildiz, Mine, Karaman, Ecem Fatma, Bas, Serap Sancar, Pirincci, Pelin Arda, Ozden, Sibel
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzhydryl Compounds - toxicity Bisphenol A Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chromatin Chromatin modifiying genes Cytotoxicity Deoxyribonucleic acid DNA DNA methylation DNA Methylation - drug effects DNMT1 protein Endocrine disruptors Endocrine Disruptors - toxicity Epoxy resins Gene expression Gene Expression Regulation - drug effects Gene regulation Genes Health risks Histone Code - drug effects Histone modifications Histones - metabolism Humans Lysine Lysine - metabolism Neuroblastoma cells Organic chemistry Phenols Phenols - toxicity Polycarbonate SH-SY5Y cells SIRT1 protein Toxicity Xenoestrogens
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