Design of synthetic materials for intracellular delivery of RNAs: From siRNA-mediated gene silencing to CRISPR/Cas gene editing

Ribonucleic acids (RNAs) possess great therapeutic potential and can be used to treat a variety of diseases. The unique biophysical properties of RNAs, such as high molecular weight, negative charge, hydrophilicity, low stability, and potential immunogenicity, require chemical modification and devel...

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Veröffentlicht in:	Nano research 2018-10, Vol.11 (10), p.5310-5337
Hauptverfasser:	Miller, Jason B., Siegwart, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic/Molecular Structure and Spectra Biomedicine Biotechnology Cellular apoptosis susceptibility protein Chemical modification Chemical synthesis Chemistry and Materials Science Condensed Matter Physics CRISPR Design modifications Gene silencing Genetic modification Genome editing Immunogenicity Intracellular Materials Science Molecular weight Nanomaterials Nanotechnology Organic chemistry Review Article Ribonucleic acid RNA siRNA Transcription
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