Water near bioinert self-assembled monolayers

For a long time, water has been speculated to play an essential role in the interactions of proteins and cells with artificial biocompatible materials. The current question is how water molecules at the interfaces affect the adsorption of proteins and the adhesion of cells. To answer this question,...

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Veröffentlicht in:Polymer journal 2018-08, Vol.50 (8), p.563-571
Hauptverfasser: Chang, Ryongsok, Asatyas, Syifa, Lkhamsuren, Ganchimeg, Hirohara, Makoto, Mondarte, Evan Angelo Quimada, Suthiwanich, Kasinan, Sekine, Taito, Hayashi, Tomohiro
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container_end_page 571
container_issue 8
container_start_page 563
container_title Polymer journal
container_volume 50
creator Chang, Ryongsok
Asatyas, Syifa
Lkhamsuren, Ganchimeg
Hirohara, Makoto
Mondarte, Evan Angelo Quimada
Suthiwanich, Kasinan
Sekine, Taito
Hayashi, Tomohiro
description For a long time, water has been speculated to play an essential role in the interactions of proteins and cells with artificial biocompatible materials. The current question is how water molecules at the interfaces affect the adsorption of proteins and the adhesion of cells. To answer this question, we introduce recent works that investigated the interfacial behavior of water near self-assembled monolayers (SAMs) by different types of analytical techniques. By combining these findings, we discuss how interfacial water affects the protein and cell resistance of various bioinert SAMs. Recent works revealed that protein and cell resistance of bioinert self-assembled monolayers originates in the physical barrier of the interfacial water. We review the history of the previous works that attempted to clarify the underlying mechanism and discuss prospects to apply the findings to design new biomaterials.
doi_str_mv 10.1038/s41428-018-0075-1
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subjects 631/57
639/301/54/990
Biocompatibility
Biomaterials
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Monolayers
Polymer Sciences
Proteins
Review
Self-assembled monolayers
Self-assembly
Surfaces and Interfaces
Thin Films
Water chemistry
title Water near bioinert self-assembled monolayers
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