Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds
The effect of the chemical nature of the surface of detonation nanodiamond on the adsorption of an antibiotic is revealed with the help of tritium-labeled amikacin. It is found that nanodiamonds with a carboxylated surface ( S sp = 283 ± 5 m 2 /g) chemisorbed twice as much amikacin as nanodiamonds w...
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| Veröffentlicht in: | Moscow University chemistry bulletin 2018-05, Vol.73 (3), p.91-98 |
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| creator | Solomatin, A. S. Yakovlev, R. Y. Leonidov, N. B. Badun, G. A. Chernysheva, M. G. Kulakova, I. I. Stavrianidi, A. N. Shlyakhtin, O. A. Lisichkin, G. V. |
| description | The effect of the chemical nature of the surface of detonation nanodiamond on the adsorption of an antibiotic is revealed with the help of tritium-labeled amikacin. It is found that nanodiamonds with a carboxylated surface (
S
sp
= 283 ± 5 m
2
/g) chemisorbed twice as much amikacin as nanodiamonds with a hydrogenated surface (
S
sp
= 289 ± 5 m
2
/g): 48 and 22 mg/g, respectively. Maintaining nanodiamonds with immobilized amikacin in the form of hydrosol for 1 month results in a release of up to 9.6 and 6.4 mg/g of the antibiotic, respectively. The results demonstrate the possibility of creating an amikacin delivery system based on nanodiamonds. |
| doi_str_mv | 10.3103/S0027131418030082 |
| format | Article |
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S
sp
= 283 ± 5 m
2
/g) chemisorbed twice as much amikacin as nanodiamonds with a hydrogenated surface (
S
sp
= 289 ± 5 m
2
/g): 48 and 22 mg/g, respectively. Maintaining nanodiamonds with immobilized amikacin in the form of hydrosol for 1 month results in a release of up to 9.6 and 6.4 mg/g of the antibiotic, respectively. The results demonstrate the possibility of creating an amikacin delivery system based on nanodiamonds.</description><identifier>ISSN: 0027-1314</identifier><identifier>EISSN: 1935-0260</identifier><identifier>DOI: 10.3103/S0027131418030082</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Adsorption ; Antibiotics ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Detonation ; Diamonds ; Nanostructure ; Organic chemistry ; Surface chemistry ; Tritium</subject><ispartof>Moscow University chemistry bulletin, 2018-05, Vol.73 (3), p.91-98</ispartof><rights>Allerton Press, Inc. 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-1241887c21fa19e3fbd1c91619c6a9391548f9bc641023a7b809f0d77d9d2d583</citedby><cites>FETCH-LOGICAL-c316t-1241887c21fa19e3fbd1c91619c6a9391548f9bc641023a7b809f0d77d9d2d583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3103/S0027131418030082$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3103/S0027131418030082$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids></links><search><creatorcontrib>Solomatin, A. S.</creatorcontrib><creatorcontrib>Yakovlev, R. Y.</creatorcontrib><creatorcontrib>Leonidov, N. B.</creatorcontrib><creatorcontrib>Badun, G. A.</creatorcontrib><creatorcontrib>Chernysheva, M. G.</creatorcontrib><creatorcontrib>Kulakova, I. I.</creatorcontrib><creatorcontrib>Stavrianidi, A. N.</creatorcontrib><creatorcontrib>Shlyakhtin, O. A.</creatorcontrib><creatorcontrib>Lisichkin, G. V.</creatorcontrib><title>Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds</title><title>Moscow University chemistry bulletin</title><addtitle>Moscow Univ. Chem. Bull</addtitle><description>The effect of the chemical nature of the surface of detonation nanodiamond on the adsorption of an antibiotic is revealed with the help of tritium-labeled amikacin. It is found that nanodiamonds with a carboxylated surface (
S
sp
= 283 ± 5 m
2
/g) chemisorbed twice as much amikacin as nanodiamonds with a hydrogenated surface (
S
sp
= 289 ± 5 m
2
/g): 48 and 22 mg/g, respectively. Maintaining nanodiamonds with immobilized amikacin in the form of hydrosol for 1 month results in a release of up to 9.6 and 6.4 mg/g of the antibiotic, respectively. The results demonstrate the possibility of creating an amikacin delivery system based on nanodiamonds.</description><subject>Adsorption</subject><subject>Antibiotics</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Detonation</subject><subject>Diamonds</subject><subject>Nanostructure</subject><subject>Organic chemistry</subject><subject>Surface chemistry</subject><subject>Tritium</subject><issn>0027-1314</issn><issn>1935-0260</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1UE1LAzEUDKJg_fgB3hY8r76XdDebYylWC8UerOclm2RLajepye5Bf71ZK3gQ4cH7mhmGIeQG4Y4hsPsXAMqR4RQrYAAVPSETFKzIgZZwSibjOx__5-Qixh1AUVLGJ0Stm15aZ9022wTb26HLV7Ixe6OzWWffpLIuk05nyz5mMx19OPTWu2zZdb6xe_spv9dUi8GpcZbpmMjP0nltZeedjlfkrJX7aK5_-iV5XTxs5k_5av24nM9WuWJY9jnSZL7iimIrURjWNhqVwBKFKqVgAotp1YpGlVMEyiRvKhAtaM610FQXFbskt0fdQ_Dvg4l9vfNDSI5iTVMiHASHEYVHlAo-xmDa-hBsJ8NHjVCPWdZ_skwceuTEhHVbE36V_yd9AYN5dYo</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Solomatin, A. S.</creator><creator>Yakovlev, R. Y.</creator><creator>Leonidov, N. B.</creator><creator>Badun, G. A.</creator><creator>Chernysheva, M. G.</creator><creator>Kulakova, I. I.</creator><creator>Stavrianidi, A. N.</creator><creator>Shlyakhtin, O. A.</creator><creator>Lisichkin, G. V.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20180501</creationdate><title>Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds</title><author>Solomatin, A. S. ; Yakovlev, R. Y. ; Leonidov, N. B. ; Badun, G. A. ; Chernysheva, M. G. ; Kulakova, I. I. ; Stavrianidi, A. N. ; Shlyakhtin, O. A. ; Lisichkin, G. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-1241887c21fa19e3fbd1c91619c6a9391548f9bc641023a7b809f0d77d9d2d583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adsorption</topic><topic>Antibiotics</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Detonation</topic><topic>Diamonds</topic><topic>Nanostructure</topic><topic>Organic chemistry</topic><topic>Surface chemistry</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solomatin, A. S.</creatorcontrib><creatorcontrib>Yakovlev, R. Y.</creatorcontrib><creatorcontrib>Leonidov, N. B.</creatorcontrib><creatorcontrib>Badun, G. A.</creatorcontrib><creatorcontrib>Chernysheva, M. G.</creatorcontrib><creatorcontrib>Kulakova, I. I.</creatorcontrib><creatorcontrib>Stavrianidi, A. N.</creatorcontrib><creatorcontrib>Shlyakhtin, O. A.</creatorcontrib><creatorcontrib>Lisichkin, G. V.</creatorcontrib><collection>CrossRef</collection><jtitle>Moscow University chemistry bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solomatin, A. S.</au><au>Yakovlev, R. Y.</au><au>Leonidov, N. B.</au><au>Badun, G. A.</au><au>Chernysheva, M. G.</au><au>Kulakova, I. I.</au><au>Stavrianidi, A. N.</au><au>Shlyakhtin, O. A.</au><au>Lisichkin, G. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds</atitle><jtitle>Moscow University chemistry bulletin</jtitle><stitle>Moscow Univ. Chem. Bull</stitle><date>2018-05-01</date><risdate>2018</risdate><volume>73</volume><issue>3</issue><spage>91</spage><epage>98</epage><pages>91-98</pages><issn>0027-1314</issn><eissn>1935-0260</eissn><abstract>The effect of the chemical nature of the surface of detonation nanodiamond on the adsorption of an antibiotic is revealed with the help of tritium-labeled amikacin. It is found that nanodiamonds with a carboxylated surface (
S
sp
= 283 ± 5 m
2
/g) chemisorbed twice as much amikacin as nanodiamonds with a hydrogenated surface (
S
sp
= 289 ± 5 m
2
/g): 48 and 22 mg/g, respectively. Maintaining nanodiamonds with immobilized amikacin in the form of hydrosol for 1 month results in a release of up to 9.6 and 6.4 mg/g of the antibiotic, respectively. The results demonstrate the possibility of creating an amikacin delivery system based on nanodiamonds.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.3103/S0027131418030082</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Adsorption Antibiotics Chemistry Chemistry and Materials Science Chemistry/Food Science Detonation Diamonds Nanostructure Organic chemistry Surface chemistry Tritium |
| title | Obtaining Tritium-Labeled Amikacin and Its Adsorption Immobilization on Functionalized Nanodiamonds |
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