Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility
Magnesium alloy has been generally accepted as an important biodegradable material on cardiovascular stent development for a long time. However, its limited biocompatibility, especially delayed endothelialization process restricts its further application. In this contribution, we modified the Mg-Zn-...
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| Veröffentlicht in: | Science China. Technological sciences 2018-08, Vol.61 (8), p.1228-1237 |
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| container_title | Science China. Technological sciences |
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| creator | Chen, Li Li, JingAn Chang, JiaWei Jin, ShiBo Wu, Di Yan, HaoHao Wang, XiaoFeng Guan, ShaoKang |
| description | Magnesium alloy has been generally accepted as an important biodegradable material on cardiovascular stent development for a long time. However, its limited biocompatibility, especially delayed endothelialization process restricts its further application. In this contribution, we modified the Mg-Zn-Y-Nd alloy surface with citric acid and dopamine via a layer-by-layer self-assembly assay, aiming at improving the biocompatibility of the magnesium alloy. The citric acid/dopamine (CA/PDA) layer exhibited a remarkable suppression of platelet activation/aggregation and thrombosis under 15 dyn/cm
2
blood flowing. Inhibition on vascular smooth muscle cells growth and macrophages attachment/activation were also observed on this layer. In particular, the CA/PDA layer presented a promoted property for the vascular endothelial cells growth and spreading compared with the bare magnesium alloy, suggesting the pro-endotelialized function. In conclusion, this research may support potential application on surface modification of magnesium alloy based cardiovascular stents for better biocompatibility. |
| doi_str_mv | 10.1007/s11431-017-9190-2 |
| format | Article |
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2
blood flowing. Inhibition on vascular smooth muscle cells growth and macrophages attachment/activation were also observed on this layer. In particular, the CA/PDA layer presented a promoted property for the vascular endothelial cells growth and spreading compared with the bare magnesium alloy, suggesting the pro-endotelialized function. In conclusion, this research may support potential application on surface modification of magnesium alloy based cardiovascular stents for better biocompatibility.</description><identifier>ISSN: 1674-7321</identifier><identifier>EISSN: 1869-1900</identifier><identifier>DOI: 10.1007/s11431-017-9190-2</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Activation ; Biocompatibility ; Biodegradability ; Biodegradable materials ; Citric acid ; Dopamine ; Endothelial cells ; Engineering ; Macrophages ; Magnesium base alloys ; Muscles ; Neodymium base alloys ; Self-assembly ; Stents ; Surgical implants ; Thrombosis ; Zinc coatings</subject><ispartof>Science China. Technological sciences, 2018-08, Vol.61 (8), p.1228-1237</ispartof><rights>Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-c9132b9d22a8a644648a9f92f29e0e12ede7f631e926edd2a990e1a3c06c05333</citedby><cites>FETCH-LOGICAL-c316t-c9132b9d22a8a644648a9f92f29e0e12ede7f631e926edd2a990e1a3c06c05333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11431-017-9190-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11431-017-9190-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Chen, Li</creatorcontrib><creatorcontrib>Li, JingAn</creatorcontrib><creatorcontrib>Chang, JiaWei</creatorcontrib><creatorcontrib>Jin, ShiBo</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Yan, HaoHao</creatorcontrib><creatorcontrib>Wang, XiaoFeng</creatorcontrib><creatorcontrib>Guan, ShaoKang</creatorcontrib><title>Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility</title><title>Science China. Technological sciences</title><addtitle>Sci. China Technol. Sci</addtitle><description>Magnesium alloy has been generally accepted as an important biodegradable material on cardiovascular stent development for a long time. However, its limited biocompatibility, especially delayed endothelialization process restricts its further application. In this contribution, we modified the Mg-Zn-Y-Nd alloy surface with citric acid and dopamine via a layer-by-layer self-assembly assay, aiming at improving the biocompatibility of the magnesium alloy. The citric acid/dopamine (CA/PDA) layer exhibited a remarkable suppression of platelet activation/aggregation and thrombosis under 15 dyn/cm
2
blood flowing. Inhibition on vascular smooth muscle cells growth and macrophages attachment/activation were also observed on this layer. In particular, the CA/PDA layer presented a promoted property for the vascular endothelial cells growth and spreading compared with the bare magnesium alloy, suggesting the pro-endotelialized function. In conclusion, this research may support potential application on surface modification of magnesium alloy based cardiovascular stents for better biocompatibility.</description><subject>Activation</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Biodegradable materials</subject><subject>Citric acid</subject><subject>Dopamine</subject><subject>Endothelial cells</subject><subject>Engineering</subject><subject>Macrophages</subject><subject>Magnesium base alloys</subject><subject>Muscles</subject><subject>Neodymium base alloys</subject><subject>Self-assembly</subject><subject>Stents</subject><subject>Surgical implants</subject><subject>Thrombosis</subject><subject>Zinc coatings</subject><issn>1674-7321</issn><issn>1869-1900</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1UMtOwzAQjBBIVKUfwM0SZ4PXTp34iCpeUoELHOBiObZTXCVxsF1Q_h5DkTixl51dzcyupihOgZwDIdVFBCgZYAIVFiAIpgfFDGoucB7IYca8KnHFKBwXixi3JBerBYFyVsT7DX4d8At-MEh7laxBny69Ie1ScBop7QxSg0HGj6p3g0XNhDo12YCbCf8AFG3XYhWj7ZtuQskj14_Bf1gUd6FVOkuc174fVXKN61yaToqjVnXRLn77vHi-vnpa3eL1483d6nKNNQOesBbAaCMMpapWvCx5WSvRCtpSYYkFao2tWs7ACsqtMVQJkdeKacI1WTLG5sXZ3je_876zMcmt34Uhn5SU1MApq2GZWbBn6eBjDLaVY3C9CpMEIr_jlft4ZY5XfscradbQvSZm7rCx4c_5f9EXFhJ9PA</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Chen, Li</creator><creator>Li, JingAn</creator><creator>Chang, JiaWei</creator><creator>Jin, ShiBo</creator><creator>Wu, Di</creator><creator>Yan, HaoHao</creator><creator>Wang, XiaoFeng</creator><creator>Guan, ShaoKang</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20180801</creationdate><title>Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility</title><author>Chen, Li ; Li, JingAn ; Chang, JiaWei ; Jin, ShiBo ; Wu, Di ; Yan, HaoHao ; Wang, XiaoFeng ; Guan, ShaoKang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-c9132b9d22a8a644648a9f92f29e0e12ede7f631e926edd2a990e1a3c06c05333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activation</topic><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>Biodegradable materials</topic><topic>Citric acid</topic><topic>Dopamine</topic><topic>Endothelial cells</topic><topic>Engineering</topic><topic>Macrophages</topic><topic>Magnesium base alloys</topic><topic>Muscles</topic><topic>Neodymium base alloys</topic><topic>Self-assembly</topic><topic>Stents</topic><topic>Surgical implants</topic><topic>Thrombosis</topic><topic>Zinc coatings</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Li</creatorcontrib><creatorcontrib>Li, JingAn</creatorcontrib><creatorcontrib>Chang, JiaWei</creatorcontrib><creatorcontrib>Jin, ShiBo</creatorcontrib><creatorcontrib>Wu, Di</creatorcontrib><creatorcontrib>Yan, HaoHao</creatorcontrib><creatorcontrib>Wang, XiaoFeng</creatorcontrib><creatorcontrib>Guan, ShaoKang</creatorcontrib><collection>CrossRef</collection><jtitle>Science China. Technological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Li</au><au>Li, JingAn</au><au>Chang, JiaWei</au><au>Jin, ShiBo</au><au>Wu, Di</au><au>Yan, HaoHao</au><au>Wang, XiaoFeng</au><au>Guan, ShaoKang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility</atitle><jtitle>Science China. Technological sciences</jtitle><stitle>Sci. China Technol. Sci</stitle><date>2018-08-01</date><risdate>2018</risdate><volume>61</volume><issue>8</issue><spage>1228</spage><epage>1237</epage><pages>1228-1237</pages><issn>1674-7321</issn><eissn>1869-1900</eissn><abstract>Magnesium alloy has been generally accepted as an important biodegradable material on cardiovascular stent development for a long time. However, its limited biocompatibility, especially delayed endothelialization process restricts its further application. In this contribution, we modified the Mg-Zn-Y-Nd alloy surface with citric acid and dopamine via a layer-by-layer self-assembly assay, aiming at improving the biocompatibility of the magnesium alloy. The citric acid/dopamine (CA/PDA) layer exhibited a remarkable suppression of platelet activation/aggregation and thrombosis under 15 dyn/cm
2
blood flowing. Inhibition on vascular smooth muscle cells growth and macrophages attachment/activation were also observed on this layer. In particular, the CA/PDA layer presented a promoted property for the vascular endothelial cells growth and spreading compared with the bare magnesium alloy, suggesting the pro-endotelialized function. In conclusion, this research may support potential application on surface modification of magnesium alloy based cardiovascular stents for better biocompatibility.</abstract><cop>Beijing</cop><pub>Science China Press</pub><doi>10.1007/s11431-017-9190-2</doi><tpages>10</tpages></addata></record> |
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| subjects | Activation Biocompatibility Biodegradability Biodegradable materials Citric acid Dopamine Endothelial cells Engineering Macrophages Magnesium base alloys Muscles Neodymium base alloys Self-assembly Stents Surgical implants Thrombosis Zinc coatings |
| title | Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility |
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