Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma

Twist is a critical epithelial-mesenchymal transition (EMT)-inducing transcription factor that increases expression of vimentin. How Twist1 regulates this expression remains unclear. Here, we report that Twist1 regulates Cullin2 (Cul2) circular RNA to increase expression of vimentin in EMT. Twist1 b...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-08, Vol.78 (15), p.4150-4162
Hauptverfasser:	Meng, Jing, Chen, Shuang, Han, Jing-Xia, Qian, Baoxin, Wang, Xiao-Rui, Zhong, Wei-Long, Qin, Yuan, Zhang, Heng, Gao, Wan-Feng, Lei, Yue-Yang, Yang, Wei, Yang, Lan, Zhang, Chao, Liu, Hui-Juan, Liu, Yan-Rong, Zhou, Hong-Gang, Sun, Tao, Yang, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Carcinoma, Hepatocellular - genetics Cell Line Cell Line, Tumor Circular RNA Cullin Proteins - genetics Diethylnitrosamine Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic - genetics HEK293 Cells Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - genetics Mesenchyme Mice Nuclear Proteins - genetics Promoter Regions, Genetic - genetics RNA - genetics RNA, Circular Signal Transduction - genetics Therapeutic applications Transgenic mice Twist-Related Protein 1 - genetics Vimentin Vimentin - genetics Xenografts
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