Label-free optical quantification of structural alterations in Alzheimer's disease

Label-free optical quantification of structural alterations in Alzheimer's disease

We present a quantitative label-free imaging of mouse whole brain tissue slices with sub-micrometre resolution, employing holographic microscopy and an automated scanning platform. From the measured light field images, scattering coefficients and anisotropies are quantitatively retrieved, which enab...

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Veröffentlicht in:arXiv.org 2016-03
Hauptverfasser: Lee, Moosung, Lee, Eeksung, Jung, JaeHwang, Yu, Hyeonseung, Kim, Kyoohyun, Lee, Shinhwa, Jeong, Yong, Park, YongKeun
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Alzheimer's disease
Brain
Scattering coefficient
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creator Lee, Moosung
Lee, Eeksung
Jung, JaeHwang
Yu, Hyeonseung
Kim, Kyoohyun
Lee, Shinhwa
Jeong, Yong
Park, YongKeun
description We present a quantitative label-free imaging of mouse whole brain tissue slices with sub-micrometre resolution, employing holographic microscopy and an automated scanning platform. From the measured light field images, scattering coefficients and anisotropies are quantitatively retrieved, which enables access to structural information about brain tissues. As a proof of principle, we demonstrate that these scattering parameters enable us to quantitatively address structural alteration in the brain tissues of mice with Alzheimer's disease.
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subjects Alzheimer's disease
Brain
Scattering coefficient
title Label-free optical quantification of structural alterations in Alzheimer's disease
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