ECG correlates of acute allograft rejection among heart transplant recipients in the NEW HEART study
Previous studies have suggested that acute allograft rejection is associated with increases in QT/QTc. This study sought to determine the relationship between acute allograft rejection and ECG changes in patients undergoing an orthotopic heart transplant. The study population consisted of 220 adult...
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| Veröffentlicht in: | Journal of electrocardiology 2017-11, Vol.50 (6), p.866-866 |
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| container_title | Journal of electrocardiology |
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| creator | Carter, Erik V. Castillo, Carmen Chen, Belinda Doering, Lynn V. Drew, Barbara J. Hickey, Kathleen T. Pickham, David Sciacca, Robert R. |
| description | Previous studies have suggested that acute allograft rejection is associated with increases in QT/QTc.
This study sought to determine the relationship between acute allograft rejection and ECG changes in patients undergoing an orthotopic heart transplant.
The study population consisted of 220 adult heart transplant patients enrolled in the NEW HEART Study. ECGs performed within 72h of endomyocardial biopsy were analyzed with ECGs obtained |
| doi_str_mv | 10.1016/j.jelectrocard.2017.08.062 |
| format | Article |
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This study sought to determine the relationship between acute allograft rejection and ECG changes in patients undergoing an orthotopic heart transplant.
The study population consisted of 220 adult heart transplant patients enrolled in the NEW HEART Study. ECGs performed within 72h of endomyocardial biopsy were analyzed with ECGs obtained <10days following transplant surgery excluded. Repeated measures analysis was performed with statistical models including effects for rejection severity (mild and moderate/severe) and time trends independent of rejection status.
Among the 151 male and 69 female transplant recipients (age 54±13), there were 969 biopsy/ECG pairs: 677 with no rejection, 280 with mild rejection, and 12 with moderate/severe rejection. Moderate/severe rejection was associated with significant increases in QRS duration (p<0.0001), QT (p=0.009), QTc (p=0.003), and PR interval (p=0.03), as well as increased odds of right bundle block branch (p=0.002) and fascicular block (p=0.009).
Moderate/severe acute allograft rejection is associated with ECG changes following transplant surgery. Future studies are needed to assess the value of computerized ECG measurement algorithms for detecting acute allograph rejection.</description><identifier>ISSN: 0022-0736</identifier><identifier>EISSN: 1532-8430</identifier><identifier>DOI: 10.1016/j.jelectrocard.2017.08.062</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Algorithms ; Electrocardiography ; Heart surgery ; Surgical outcomes ; Transplants & implants</subject><ispartof>Journal of electrocardiology, 2017-11, Vol.50 (6), p.866-866</ispartof><rights>2017</rights><rights>Copyright Elsevier Science Ltd. Nov/Dec 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022073617303072$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Carter, Erik V.</creatorcontrib><creatorcontrib>Castillo, Carmen</creatorcontrib><creatorcontrib>Chen, Belinda</creatorcontrib><creatorcontrib>Doering, Lynn V.</creatorcontrib><creatorcontrib>Drew, Barbara J.</creatorcontrib><creatorcontrib>Hickey, Kathleen T.</creatorcontrib><creatorcontrib>Pickham, David</creatorcontrib><creatorcontrib>Sciacca, Robert R.</creatorcontrib><title>ECG correlates of acute allograft rejection among heart transplant recipients in the NEW HEART study</title><title>Journal of electrocardiology</title><description>Previous studies have suggested that acute allograft rejection is associated with increases in QT/QTc.
This study sought to determine the relationship between acute allograft rejection and ECG changes in patients undergoing an orthotopic heart transplant.
The study population consisted of 220 adult heart transplant patients enrolled in the NEW HEART Study. ECGs performed within 72h of endomyocardial biopsy were analyzed with ECGs obtained <10days following transplant surgery excluded. Repeated measures analysis was performed with statistical models including effects for rejection severity (mild and moderate/severe) and time trends independent of rejection status.
Among the 151 male and 69 female transplant recipients (age 54±13), there were 969 biopsy/ECG pairs: 677 with no rejection, 280 with mild rejection, and 12 with moderate/severe rejection. Moderate/severe rejection was associated with significant increases in QRS duration (p<0.0001), QT (p=0.009), QTc (p=0.003), and PR interval (p=0.03), as well as increased odds of right bundle block branch (p=0.002) and fascicular block (p=0.009).
Moderate/severe acute allograft rejection is associated with ECG changes following transplant surgery. Future studies are needed to assess the value of computerized ECG measurement algorithms for detecting acute allograph rejection.</description><subject>Algorithms</subject><subject>Electrocardiography</subject><subject>Heart surgery</subject><subject>Surgical outcomes</subject><subject>Transplants & implants</subject><issn>0022-0736</issn><issn>1532-8430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkE9LwzAYxoMoOKffIei59U3atam3MesmDAWZeAwxebu1dE1NUmHf3o558OjpuTx_eH6E3DKIGbDsvokbbFEHZ7VyJubA8hhEDBk_IxM2S3gk0gTOyQSA8wjyJLskV943AFDwnE-IKRdLqq1z2KqAntqKKj0EpKpt7dapKlCHzbhQ246qve22dIfKBRqc6nzfqu5o0HVfYxc8rTsadkhfyg-6KudvG-rDYA7X5KJSrcebX52S96dys1hF69fl82K-jjRLIY0UF8JkLC0U5CwRRn-mChkIk2ZYFLkoNMMCMUUUVZbziqVCgy4KITKhq8QkU3J36u2d_RrQB9nYwXXjpOSQ5zMBMOKYkoeTSzvrvcNK9q7eK3eQDOSRqmzkX6rySFWCkCPVMfx4CuP447tGJ70er2s09YghSGPr_9T8AMYUh2E</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Carter, Erik V.</creator><creator>Castillo, Carmen</creator><creator>Chen, Belinda</creator><creator>Doering, Lynn V.</creator><creator>Drew, Barbara J.</creator><creator>Hickey, Kathleen T.</creator><creator>Pickham, David</creator><creator>Sciacca, Robert R.</creator><general>Elsevier Inc</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201711</creationdate><title>ECG correlates of acute allograft rejection among heart transplant recipients in the NEW HEART study</title><author>Carter, Erik V. ; Castillo, Carmen ; Chen, Belinda ; Doering, Lynn V. ; Drew, Barbara J. ; Hickey, Kathleen T. ; Pickham, David ; Sciacca, Robert R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1404-a288d6149a07138dcb4ae108d46e99789c1e9ee4ee8f672f148c0c998868cf3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Algorithms</topic><topic>Electrocardiography</topic><topic>Heart surgery</topic><topic>Surgical outcomes</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carter, Erik V.</creatorcontrib><creatorcontrib>Castillo, Carmen</creatorcontrib><creatorcontrib>Chen, Belinda</creatorcontrib><creatorcontrib>Doering, Lynn V.</creatorcontrib><creatorcontrib>Drew, Barbara J.</creatorcontrib><creatorcontrib>Hickey, Kathleen T.</creatorcontrib><creatorcontrib>Pickham, David</creatorcontrib><creatorcontrib>Sciacca, Robert R.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of electrocardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carter, Erik V.</au><au>Castillo, Carmen</au><au>Chen, Belinda</au><au>Doering, Lynn V.</au><au>Drew, Barbara J.</au><au>Hickey, Kathleen T.</au><au>Pickham, David</au><au>Sciacca, Robert R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ECG correlates of acute allograft rejection among heart transplant recipients in the NEW HEART study</atitle><jtitle>Journal of electrocardiology</jtitle><date>2017-11</date><risdate>2017</risdate><volume>50</volume><issue>6</issue><spage>866</spage><epage>866</epage><pages>866-866</pages><issn>0022-0736</issn><eissn>1532-8430</eissn><abstract>Previous studies have suggested that acute allograft rejection is associated with increases in QT/QTc.
This study sought to determine the relationship between acute allograft rejection and ECG changes in patients undergoing an orthotopic heart transplant.
The study population consisted of 220 adult heart transplant patients enrolled in the NEW HEART Study. ECGs performed within 72h of endomyocardial biopsy were analyzed with ECGs obtained <10days following transplant surgery excluded. Repeated measures analysis was performed with statistical models including effects for rejection severity (mild and moderate/severe) and time trends independent of rejection status.
Among the 151 male and 69 female transplant recipients (age 54±13), there were 969 biopsy/ECG pairs: 677 with no rejection, 280 with mild rejection, and 12 with moderate/severe rejection. Moderate/severe rejection was associated with significant increases in QRS duration (p<0.0001), QT (p=0.009), QTc (p=0.003), and PR interval (p=0.03), as well as increased odds of right bundle block branch (p=0.002) and fascicular block (p=0.009).
Moderate/severe acute allograft rejection is associated with ECG changes following transplant surgery. Future studies are needed to assess the value of computerized ECG measurement algorithms for detecting acute allograph rejection.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><doi>10.1016/j.jelectrocard.2017.08.062</doi><tpages>1</tpages></addata></record> |
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| subjects | Algorithms Electrocardiography Heart surgery Surgical outcomes Transplants & implants |
| title | ECG correlates of acute allograft rejection among heart transplant recipients in the NEW HEART study |
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