Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity associated type 2 diabetes

Type 2 diabetes (T2D) is closely linked with non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance, but the involved mechanisms are still elusive. Using DNA methylome and transcriptome analyses of livers from obese individuals, we found that both hypomethylation at a CpG site in P...

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Veröffentlicht in:	arXiv.org 2017-12
Hauptverfasser:	Abderrahmani, Amar, Yengo, Loic, Caiazzo, Robert, Canouil, Mickael, Cauchi, Stephane, Raverdy, Violeta, Plaisance, Valerie, Pawlowski, Valerie, Lobbens, Stephane, Maillet, Julie, Rolland, Laure, Boutry, Raphael, Queniat, Gurvan, Kwapich, Maxime, Tenenbaum, Mathie, Bricambert, Julien, Saussenthaler, Sophie, Anthony, Elodie, Jha, Pooja, Derop, Julien, Sand, Olivier, Rabearivelo, Iandry, Leloire, Audrey, Pigeyre, Marie, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine, Dayeh, Tasnim, Lassailly, Guillaume, Mathurin, Philippe, Staels, Bart, Auwerx, Johan, Schurmann, Annette, Postic, Catherine, Schafmayer, Clemens, Hampe, Jochen, Bonnefond, Amelie, Pattou, Francois, Froguel, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Deoxyribonucleic acid Diabetes Diabetes mellitus DNA Growth factors Insulin Insulin resistance Kinases Liver Metformin Proteins Risk Signaling Substrates
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