The Role of the Receptor Tyrosine Kinase Ron in Nickel-Induced Acute Lung Injury
Acute lung injury (ALI), a severe respiratory syndrome, develops in response to numerous insults and responds poorly to therapeutic intervention. Recently, cDNA microarray analyses were performed that indicated several pathogenic responses during nickel-induced ALI, including marked macrophage activ...
Gespeichert in:
| Veröffentlicht in: | American journal of respiratory cell and molecular biology 2002-01, Vol.26 (1), p.99-104 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 104 |
|---|---|
| container_issue | 1 |
| container_start_page | 99 |
| container_title | American journal of respiratory cell and molecular biology |
| container_volume | 26 |
| creator | McDowell, Susan A Mallakin, Ali Bachurski, Cindy J Toney-Earley, Kenya Prows, Daniel R Bruno, Theresa Kaestner, Klaus H Witte, David P Melin-Aldana, Hector Degen, Sandra J. F Leikauf, George D Waltz, Susan E |
| description | Acute lung injury (ALI), a severe respiratory syndrome, develops in response to numerous insults and responds poorly to therapeutic intervention. Recently, cDNA microarray analyses were performed that indicated several pathogenic responses during nickel-induced ALI, including marked macrophage activation. Macrophage activation is mediated, in part, via the receptor tyrosine kinase Ron. To address the role of Ron in ALI, the response of mice deficient in the cytoplasmic domain of Ron (Ron tk-/-) were assessed in response to nickel exposure. Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Increases in cytokine expression and cellular nitration can lead to tissue damage and are consistent with the differences between genotypes in the early onset of pathology and mortality in Ron tk-/- mice. These analyses indicate a role for the tyrosine kinase receptor Ron in ALI. |
| doi_str_mv | 10.1165/ajrcmb.26.1.4621 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_207648199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>102188169</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-8f67078c46e80892967ac8463ba5d3176e3f598e9ef66094a72caa02a7172113</originalsourceid><addsrcrecordid>eNpFkEtPwzAQhC0EoqVw54QsLpxSvI7jx7FCPCoqQCh3y3U2bUqaFCcR6r8noZU47Ry-mdEOIdfApgAyuXeb4LfLKZdTmArJ4YSMIYmTSBhtTnvNhIggEWZELppmwxhwDXBORgAqAc7MmHyka6SfdYm0zmk7aPS4a-tA032om6JC-lpUrhmgihYVfSv8F5bRvMo6jxmd-a5FuuiqFZ1Xmy7sL8lZ7soGr453QtKnx_ThJVq8P88fZovIx4loI51LxZT2QqJm2nAjlfNayHjpkiwGJTHOE6PRYC4lM8Ip7p1j3ClQHCCekNtD7C7U3x02rd3UXaj6RsuZkkKDMT3EDpDvX2kC5nYXiq0LewvMDgPaw4CWSwt2GLC33Bxzu-UWs3_DcbEeuDsA62K1_ikC2mbryrLH4Zj2F9a3_wKKx3i_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>207648199</pqid></control><display><type>article</type><title>The Role of the Receptor Tyrosine Kinase Ron in Nickel-Induced Acute Lung Injury</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><source>Alma/SFX Local Collection</source><creator>McDowell, Susan A ; Mallakin, Ali ; Bachurski, Cindy J ; Toney-Earley, Kenya ; Prows, Daniel R ; Bruno, Theresa ; Kaestner, Klaus H ; Witte, David P ; Melin-Aldana, Hector ; Degen, Sandra J. F ; Leikauf, George D ; Waltz, Susan E</creator><creatorcontrib>McDowell, Susan A ; Mallakin, Ali ; Bachurski, Cindy J ; Toney-Earley, Kenya ; Prows, Daniel R ; Bruno, Theresa ; Kaestner, Klaus H ; Witte, David P ; Melin-Aldana, Hector ; Degen, Sandra J. F ; Leikauf, George D ; Waltz, Susan E</creatorcontrib><description>Acute lung injury (ALI), a severe respiratory syndrome, develops in response to numerous insults and responds poorly to therapeutic intervention. Recently, cDNA microarray analyses were performed that indicated several pathogenic responses during nickel-induced ALI, including marked macrophage activation. Macrophage activation is mediated, in part, via the receptor tyrosine kinase Ron. To address the role of Ron in ALI, the response of mice deficient in the cytoplasmic domain of Ron (Ron tk-/-) were assessed in response to nickel exposure. Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Increases in cytokine expression and cellular nitration can lead to tissue damage and are consistent with the differences between genotypes in the early onset of pathology and mortality in Ron tk-/- mice. These analyses indicate a role for the tyrosine kinase receptor Ron in ALI.</description><identifier>ISSN: 1044-1549</identifier><identifier>EISSN: 1535-4989</identifier><identifier>DOI: 10.1165/ajrcmb.26.1.4621</identifier><identifier>PMID: 11751209</identifier><identifier>CODEN: AJRBEL</identifier><language>eng</language><publisher>United States: Am Thoracic Soc</publisher><subject>Androstadienes - pharmacology ; Animals ; Cell Survival ; Chemokine CCL2 - biosynthesis ; Chemokine CCL8 ; Cytokines - biosynthesis ; Cytoplasm - metabolism ; DNA, Complementary - metabolism ; Female ; Gene Deletion ; Genotype ; Humans ; Interleukin-6 - biosynthesis ; Lung Injury ; Macrophages, Alveolar - metabolism ; Male ; Mice ; Monocyte Chemoattractant Proteins - biosynthesis ; Nickel - toxicity ; Nitrites - blood ; Nitrites - metabolism ; Oligonucleotide Array Sequence Analysis ; Protein Structure, Tertiary ; Receptor Protein-Tyrosine Kinases - genetics ; Receptor Protein-Tyrosine Kinases - physiology ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - physiology ; Respiratory Distress Syndrome, Adult - chemically induced ; Signal Transduction ; Time Factors ; Tyrosine - metabolism</subject><ispartof>American journal of respiratory cell and molecular biology, 2002-01, Vol.26 (1), p.99-104</ispartof><rights>Copyright American Lung Association Jan 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-8f67078c46e80892967ac8463ba5d3176e3f598e9ef66094a72caa02a7172113</citedby><cites>FETCH-LOGICAL-c354t-8f67078c46e80892967ac8463ba5d3176e3f598e9ef66094a72caa02a7172113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11751209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McDowell, Susan A</creatorcontrib><creatorcontrib>Mallakin, Ali</creatorcontrib><creatorcontrib>Bachurski, Cindy J</creatorcontrib><creatorcontrib>Toney-Earley, Kenya</creatorcontrib><creatorcontrib>Prows, Daniel R</creatorcontrib><creatorcontrib>Bruno, Theresa</creatorcontrib><creatorcontrib>Kaestner, Klaus H</creatorcontrib><creatorcontrib>Witte, David P</creatorcontrib><creatorcontrib>Melin-Aldana, Hector</creatorcontrib><creatorcontrib>Degen, Sandra J. F</creatorcontrib><creatorcontrib>Leikauf, George D</creatorcontrib><creatorcontrib>Waltz, Susan E</creatorcontrib><title>The Role of the Receptor Tyrosine Kinase Ron in Nickel-Induced Acute Lung Injury</title><title>American journal of respiratory cell and molecular biology</title><addtitle>Am J Respir Cell Mol Biol</addtitle><description>Acute lung injury (ALI), a severe respiratory syndrome, develops in response to numerous insults and responds poorly to therapeutic intervention. Recently, cDNA microarray analyses were performed that indicated several pathogenic responses during nickel-induced ALI, including marked macrophage activation. Macrophage activation is mediated, in part, via the receptor tyrosine kinase Ron. To address the role of Ron in ALI, the response of mice deficient in the cytoplasmic domain of Ron (Ron tk-/-) were assessed in response to nickel exposure. Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Increases in cytokine expression and cellular nitration can lead to tissue damage and are consistent with the differences between genotypes in the early onset of pathology and mortality in Ron tk-/- mice. These analyses indicate a role for the tyrosine kinase receptor Ron in ALI.</description><subject>Androstadienes - pharmacology</subject><subject>Animals</subject><subject>Cell Survival</subject><subject>Chemokine CCL2 - biosynthesis</subject><subject>Chemokine CCL8</subject><subject>Cytokines - biosynthesis</subject><subject>Cytoplasm - metabolism</subject><subject>DNA, Complementary - metabolism</subject><subject>Female</subject><subject>Gene Deletion</subject><subject>Genotype</subject><subject>Humans</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Lung Injury</subject><subject>Macrophages, Alveolar - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Monocyte Chemoattractant Proteins - biosynthesis</subject><subject>Nickel - toxicity</subject><subject>Nitrites - blood</subject><subject>Nitrites - metabolism</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Protein Structure, Tertiary</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptor Protein-Tyrosine Kinases - physiology</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Respiratory Distress Syndrome, Adult - chemically induced</subject><subject>Signal Transduction</subject><subject>Time Factors</subject><subject>Tyrosine - metabolism</subject><issn>1044-1549</issn><issn>1535-4989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkEtPwzAQhC0EoqVw54QsLpxSvI7jx7FCPCoqQCh3y3U2bUqaFCcR6r8noZU47Ry-mdEOIdfApgAyuXeb4LfLKZdTmArJ4YSMIYmTSBhtTnvNhIggEWZELppmwxhwDXBORgAqAc7MmHyka6SfdYm0zmk7aPS4a-tA032om6JC-lpUrhmgihYVfSv8F5bRvMo6jxmd-a5FuuiqFZ1Xmy7sL8lZ7soGr453QtKnx_ThJVq8P88fZovIx4loI51LxZT2QqJm2nAjlfNayHjpkiwGJTHOE6PRYC4lM8Ip7p1j3ClQHCCekNtD7C7U3x02rd3UXaj6RsuZkkKDMT3EDpDvX2kC5nYXiq0LewvMDgPaw4CWSwt2GLC33Bxzu-UWs3_DcbEeuDsA62K1_ikC2mbryrLH4Zj2F9a3_wKKx3i_</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>McDowell, Susan A</creator><creator>Mallakin, Ali</creator><creator>Bachurski, Cindy J</creator><creator>Toney-Earley, Kenya</creator><creator>Prows, Daniel R</creator><creator>Bruno, Theresa</creator><creator>Kaestner, Klaus H</creator><creator>Witte, David P</creator><creator>Melin-Aldana, Hector</creator><creator>Degen, Sandra J. F</creator><creator>Leikauf, George D</creator><creator>Waltz, Susan E</creator><general>Am Thoracic Soc</general><general>American Thoracic Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>20020101</creationdate><title>The Role of the Receptor Tyrosine Kinase Ron in Nickel-Induced Acute Lung Injury</title><author>McDowell, Susan A ; Mallakin, Ali ; Bachurski, Cindy J ; Toney-Earley, Kenya ; Prows, Daniel R ; Bruno, Theresa ; Kaestner, Klaus H ; Witte, David P ; Melin-Aldana, Hector ; Degen, Sandra J. F ; Leikauf, George D ; Waltz, Susan E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-8f67078c46e80892967ac8463ba5d3176e3f598e9ef66094a72caa02a7172113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Androstadienes - pharmacology</topic><topic>Animals</topic><topic>Cell Survival</topic><topic>Chemokine CCL2 - biosynthesis</topic><topic>Chemokine CCL8</topic><topic>Cytokines - biosynthesis</topic><topic>Cytoplasm - metabolism</topic><topic>DNA, Complementary - metabolism</topic><topic>Female</topic><topic>Gene Deletion</topic><topic>Genotype</topic><topic>Humans</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Lung Injury</topic><topic>Macrophages, Alveolar - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Monocyte Chemoattractant Proteins - biosynthesis</topic><topic>Nickel - toxicity</topic><topic>Nitrites - blood</topic><topic>Nitrites - metabolism</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Protein Structure, Tertiary</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Receptor Protein-Tyrosine Kinases - physiology</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Respiratory Distress Syndrome, Adult - chemically induced</topic><topic>Signal Transduction</topic><topic>Time Factors</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McDowell, Susan A</creatorcontrib><creatorcontrib>Mallakin, Ali</creatorcontrib><creatorcontrib>Bachurski, Cindy J</creatorcontrib><creatorcontrib>Toney-Earley, Kenya</creatorcontrib><creatorcontrib>Prows, Daniel R</creatorcontrib><creatorcontrib>Bruno, Theresa</creatorcontrib><creatorcontrib>Kaestner, Klaus H</creatorcontrib><creatorcontrib>Witte, David P</creatorcontrib><creatorcontrib>Melin-Aldana, Hector</creatorcontrib><creatorcontrib>Degen, Sandra J. F</creatorcontrib><creatorcontrib>Leikauf, George D</creatorcontrib><creatorcontrib>Waltz, Susan E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>American journal of respiratory cell and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McDowell, Susan A</au><au>Mallakin, Ali</au><au>Bachurski, Cindy J</au><au>Toney-Earley, Kenya</au><au>Prows, Daniel R</au><au>Bruno, Theresa</au><au>Kaestner, Klaus H</au><au>Witte, David P</au><au>Melin-Aldana, Hector</au><au>Degen, Sandra J. F</au><au>Leikauf, George D</au><au>Waltz, Susan E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of the Receptor Tyrosine Kinase Ron in Nickel-Induced Acute Lung Injury</atitle><jtitle>American journal of respiratory cell and molecular biology</jtitle><addtitle>Am J Respir Cell Mol Biol</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>26</volume><issue>1</issue><spage>99</spage><epage>104</epage><pages>99-104</pages><issn>1044-1549</issn><eissn>1535-4989</eissn><coden>AJRBEL</coden><abstract>Acute lung injury (ALI), a severe respiratory syndrome, develops in response to numerous insults and responds poorly to therapeutic intervention. Recently, cDNA microarray analyses were performed that indicated several pathogenic responses during nickel-induced ALI, including marked macrophage activation. Macrophage activation is mediated, in part, via the receptor tyrosine kinase Ron. To address the role of Ron in ALI, the response of mice deficient in the cytoplasmic domain of Ron (Ron tk-/-) were assessed in response to nickel exposure. Ron tk-/- mice succumb to nickel-induced ALI earlier, express larger, early increases in interleukin-6, monocyte chemoattractant protein-1, and macrophage inflammatory protein-2, display greater serum nitrite levels, and exhibit earlier onset of pulmonary pathology and augmented pulmonary tyrosine nitrosylation. Increases in cytokine expression and cellular nitration can lead to tissue damage and are consistent with the differences between genotypes in the early onset of pathology and mortality in Ron tk-/- mice. These analyses indicate a role for the tyrosine kinase receptor Ron in ALI.</abstract><cop>United States</cop><pub>Am Thoracic Soc</pub><pmid>11751209</pmid><doi>10.1165/ajrcmb.26.1.4621</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1044-1549 |
| ispartof | American journal of respiratory cell and molecular biology, 2002-01, Vol.26 (1), p.99-104 |
| issn | 1044-1549 1535-4989 |
| language | eng |
| recordid | cdi_proquest_journals_207648199 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Androstadienes - pharmacology Animals Cell Survival Chemokine CCL2 - biosynthesis Chemokine CCL8 Cytokines - biosynthesis Cytoplasm - metabolism DNA, Complementary - metabolism Female Gene Deletion Genotype Humans Interleukin-6 - biosynthesis Lung Injury Macrophages, Alveolar - metabolism Male Mice Monocyte Chemoattractant Proteins - biosynthesis Nickel - toxicity Nitrites - blood Nitrites - metabolism Oligonucleotide Array Sequence Analysis Protein Structure, Tertiary Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - physiology Receptors, Cell Surface - genetics Receptors, Cell Surface - physiology Respiratory Distress Syndrome, Adult - chemically induced Signal Transduction Time Factors Tyrosine - metabolism |
| title | The Role of the Receptor Tyrosine Kinase Ron in Nickel-Induced Acute Lung Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T13%3A18%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Role%20of%20the%20Receptor%20Tyrosine%20Kinase%20Ron%20in%20Nickel-Induced%20Acute%20Lung%20Injury&rft.jtitle=American%20journal%20of%20respiratory%20cell%20and%20molecular%20biology&rft.au=McDowell,%20Susan%20A&rft.date=2002-01-01&rft.volume=26&rft.issue=1&rft.spage=99&rft.epage=104&rft.pages=99-104&rft.issn=1044-1549&rft.eissn=1535-4989&rft.coden=AJRBEL&rft_id=info:doi/10.1165/ajrcmb.26.1.4621&rft_dat=%3Cproquest_cross%3E102188169%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=207648199&rft_id=info:pmid/11751209&rfr_iscdi=true |