A Biphasic Response to Silica: I. Immunostimulation Is Restricted to the Early Stage of Silicosis in Lewis Rats

Inhalation of crystalline silica may lead to acute or chronic silicosis. Although chronic silicosis is associated with increased incidence/exacerbation of autoimmune disorders, the immunologic effects of chronic silicosis are not completely understood. In an animal model of chronic silicosis, Lewis...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2004-06, Vol.30 (6), p.823-829
Hauptverfasser:	Langley, Raymond J, Kalra, Roma, Mishra, Neerad C, Hahn, Fletcher F, Razani-Boroujerdi, Seddigheh, Singh, Shashi P, Benson, Janet M, Pena-Philippides, Juan Carlos, Barr, Edward B, Sopori, Mohan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Chemistry Bronchoalveolar Lavage Fluid - chemistry Disease Models, Animal Immune System - physiology Lung - cytology Lung - metabolism Lung - pathology Male Particle Size Rats Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Silicon Dioxide - chemistry Silicon Dioxide - immunology Silicon Dioxide - metabolism Silicosis - immunology Silicosis - metabolism Silicosis - pathology Spleen - chemistry Spleen - cytology Spleen - metabolism
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