Apoptosis Underlies Immunopathogenic Mechanisms in Acute Silicosis

We investigated immunopathogenic roles for apoptosis in acute murine silicosis. Intratracheal silica instillation induced pulmonary inflammation and enlarged thoracic lymph nodes. Lymphocytes from silica-exposed lymph nodes showed reduced mitogenic responses to T cell receptor (TCR) stimulation, and...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2002-07, Vol.27 (1), p.78-84
Hauptverfasser:	Borges, Valeria M, Lopes, Marcela F, Falcao, Haroldo, Leite-Junior, Jose Henrique, Rocco, Patricia R. M, Davidson, Wendy F, Linden, Rafael, Zin, Walter A, DosReis, George A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Animals, Genetically Modified Apoptosis - immunology Apoptosis - physiology Caspase Inhibitors Cell Division - drug effects Disease Models, Animal Enzyme Inhibitors - pharmacology Fas Ligand Protein Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - pathology Lymphocytes - immunology Macrophages - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Neutrophils - drug effects Silicon Dioxide - adverse effects Silicosis - etiology Silicosis - immunology Silicosis - pathology Thorax - immunology Thorax - physiology
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