Urodilatin, a Natriuretic Peptide Stimulating Particulate Guanylate Cyclase, and the Phosphodiesterase 5 Inhibitor Dipyridamole Attenuate Experimental Pulmonary Hypertension . Synergism upon Coapplication

In a model of acute pulmonary hypertension in intact rabbits, we investigated the vasodilatory potency of intravascularly administered urodilatin, a renal natriuretic peptide type A known to stimulate particulate guanylate cyclase. Urodilatin infusion was performed in the absence and presence of the...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2001-08, Vol.25 (2), p.219-225
Hauptverfasser:	Schermuly, Ralph Theo, Weissmann, Norbert, Enke, Beate, Ghofrani, Hossein Ardeschir, Forssmann, Wolf Georg, Grimminger, Friedrich, Seeger, Werner, Walmrath, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - toxicity Administration, Inhalation Animals Atrial Natriuretic Factor - administration & dosage Atrial Natriuretic Factor - pharmacology Blood Pressure - drug effects Cyclic GMP - blood Dipyridamole - administration & dosage Dipyridamole - pharmacology Disease Models, Animal Drug Synergism Guanylate Cyclase - metabolism Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - physiopathology Hypertension, Pulmonary - prevention & control Infusions, Intravenous Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Phosphodiesterase Inhibitors - administration & dosage Phosphodiesterase Inhibitors - pharmacology Pulmonary Artery - drug effects Pulmonary Artery - physiopathology Pulmonary Circulation - drug effects Rabbits
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