Epithelial Expression of Profibrotic Mediators in a Model of Allergen-Induced Airway Remodeling

Airway remodeling, including subepithelial fibrosis, is a characteristic feature of asthma and likely contributes to the pathogenesis of airway hyperresponsiveness. We examined expression of genes related to airway wall fibrosis in a model of chronic allergen-induced airway dysfunction using laser c...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2005-02, Vol.32 (2), p.99-107
Hauptverfasser:	Kelly, Margaret M, Leigh, Richard, Bonniaud, Philippe, Ellis, Russ, Wattie, Jennifer, Smith, Mary Jo, Martin, Gail, Panju, Mohammed, Inman, Mark D, Gauldie, Jack
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - administration & dosage Animals Biomarkers - metabolism Bronchi - metabolism Bronchi - pathology Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - pathology Epithelium - metabolism Epithelium - pathology Female Fibrosis - metabolism Fibrosis - pathology Gene Expression Regulation Mice Mice, Inbred BALB C Muscle, Smooth - metabolism Muscle, Smooth - pathology Ovalbumin - administration & dosage Plasminogen Activator Inhibitor 1 - biosynthesis Plasminogen Activator Inhibitor 1 - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - genetics Transforming Growth Factor beta1
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