Role of Iron in Inactivation of Epidermal Growth Factor Receptor after Asbestos Treatment of Human Lung and Pleural Target Cells

Although the mechanism by which asbestos causes cancer remains unknown, iron associated with asbestos is thought to play a role in the pathogenic effects of fibers. Here, we examined the effects of asbestos on the epidermal growth factor receptor (EGFR) in human lung epithelial (A549) cells, human p...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2005-05, Vol.32 (5), p.436-442
Hauptverfasser:	Baldys, Aleksander, Aust, Ann E
Format:	Artikel
Sprache:	eng
Schlagworte:	Asbestos - toxicity Asbestos, Crocidolite - toxicity Carcinogens - toxicity Cell Line Cytochalasin B - metabolism Cytochalasin D - metabolism Deferoxamine - metabolism Dose-Response Relationship, Drug Endocytosis Humans Iron - metabolism Iron Chelating Agents - metabolism Lung - cytology Lung - drug effects Mineral Fibers - toxicity Phosphorylation Phytic Acid - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism
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