EGFR Signaling Is Required for TGF-ß1-Mediated COX-2 Induction in Human Bronchial Epithelial Cells

Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins and thromboxanes from free arachidonic acid. Increasing evidence suggests that COX-2 plays a role in tumorigenesis. A variety of stimuli induce COX-2 and it is overexpressed in many tumors, including non-small cell lung can...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2007-11, Vol.37 (5), p.578
Hauptverfasser:	Liu, Ming, Yang, Seok-Chul, Sharma, Sherven, Luo, Jie, Cui, Xiaoyan, Peebles, Katherine A, Huang, Min, Sato, Mitsuo, Ramirez, Ruben D, Shay, Jerry W, Minna, John D, Dubinett, Steven M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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