Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate

We have investigated the activation of phospholipase D (PLD) by sphingosine and its derivatives in bovine pulmonary artery endothelial cells (BPAEC) prelabeled with [32P]orthophosphate or [32P]lyso phospholipids. Sphingosine, in a dose- and time-dependent manner, stimulated the hydrolysis of [32P]ph...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of respiratory cell and molecular biology 1994-08, Vol.11 (2), p.221-229
Hauptverfasser:	Natarajan, V, Jayaram, HN, Scribner, WM, Garcia, JG
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Calcium - metabolism Cattle Cell Survival - drug effects Cells, Cultured Deoxyglucose - metabolism Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Enzyme Activation Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Kinetics Lysophospholipids - metabolism Phosphates - metabolism Phosphatidic Acids - metabolism Phospholipase D - metabolism Phospholipids - biosynthesis Phospholipids - metabolism Phosphorus Radioisotopes Protein Kinase C - metabolism Pulmonary Artery Ribonucleotides - metabolism Sphingosine - analogs & derivatives Sphingosine - pharmacology Tetradecanoylphorbol Acetate - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!